Abstract: Objective： To investigate the pathological changes of the nasal mucosa in guinea pigs with allergic rhinitis. Methods： Toluene 2, 4-diisocyanate was mixed with florence oil in a concentration of 10% and this solution was dripped into the nostrils to induce a sensitization process. Eight guinea pigs were established with allergic rhinitis by this solution and another 8 were used as controls. Nasal mucosa tissues were observed under a light microscope. Results： False multiple coat cilium columnar epithelial cells of the nasal mucosa in the control group were found successive, intact and distinct. Normal mucosal epithelium, lamina propria and submucosa were also found in the control group. However, in the experimental group mucosal epithelium was damaged and shed, goblet cells were proliferated, squamose metaplasm and epithelial necrosis occurred, serous glands in the lamina propria were vigorously proliferated, blood vessels were expanded, tissue edema was formed, and plenty of inflammatory cells such as eosinophil and mast cells were present in great number and infiltrated, which were all roughly identical to the clinical manifestations of allergic rhinitis. Conclusion： The nasal mucosa in allergic rhinitis has characteristics of inflammatory pathological changes.

Key words: Rhinitis, allergic, Disease models, animal, Nasal mucosa, Pathology