JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (1): 9-13.doi: 10.6040/j.issn.1673-3770.0.2015.490

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Catgut implantation at acupoints regulate immunity of sd rat with allergic rhinitis.

LIU Min1, ZHANG Dazheng1, LI Xinrong2, ZHANG Fubing3, WANG Xiaopei2, QI Yinhui4, ZHANG Qinxiu2.   

  1. Department of Otolaryngology, 1.Dujiangyan Peoples Hospital, Dujiangyan 611830, Sichuan, China;2.Teaching Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China;3.Leshan Hospital of Traditional Chinese Medicine, Leshan 614000, Sichuan, China;4.Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, Gansu, China
  • Received:2015-11-18 Online:2016-02-16 Published:2016-02-16

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Abstract: Objective To explore the effect of catgut implantation at acupoints on allergic rhinitis(AR)animals and to discuss the mechanism based on pathological morphology and immunology. Methods A total of 70 healthy SPF SD rats were randomly divided into the blank group, the AR model group, the AR western medicine group, the AR false catgut implantation at acupoint group and the AR catgut implantation at acupoint group. AR animal models were established according to the method of improved ovalbumin injection and nasal mucosa stimulation. Every group received different therapies except the blank group. After the last treatment day, ovalbumin nasal mucosa stimulation was carried out, then the symptoms were observed and recorded. SD rats were killed and septum mucosa was collected to detect expressions of tissue TGF-β1 and IL-17 by using immunohistochemical method. Results Catgut implantation at acupoints can obviously alleviate the symptoms of sneezing, runny nose and scratching of AR rats. Compared with model group(Ⅱ), catgut implantation at acupoints can reduce the TGF-β1 and IL-17 content in the AR rat nasal mucosa. False catgut implantation at acupoints can reduce the TGF-β1 content. Conclusion Catgut implantation at acupoints can reduce the TGF-β 1 and IL-17 content to regulate immune system in AR rat nasal mucosa, then alleviate AR rats symptoms.

Key words: Animal experiment, Catgut implantation at acupoints, TGF-β1, IL-17, Allergic rhinitis, Immunity

CLC Number: 

  • R765.21
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