Abstract:

 Objective   To detect expression of maspin protein and to explore the correlation between maspin and p53 proteins in laryngeal carcinoma, and explore their roles in the development of cancer. Method   Maspin and p53 protein expressions were evaluated in 78 patients with laryngeal squamous cell carcinoma(LSCC) by immunohistochemical staining. Results   LSCC expressed maspin protein in 43/78(55.1%) cases. The depression of maspin protein was related to low cell differentiation and lymph node metastasis. The gross positive expression rate of p53 was 58.9%(46/78). In the maspin-positive LSCC, p53 expression was found in 34/43 cases(79.1%), while among the maspin-negative cases, the p53 expression rate was 34.3%. There was significant difference between the two groups. Spearman rank correlation analysis showed a strong inverse correlation between maspin expression and p53(P<0.05).  Conclusions   Expression of maspin inhibits the development of LSCC. It is inversely correlated with p53, suggesting that maspin is an effector of mutanttype p53.

Key words: Laryngeal carcinoma; Maspin; p53; Immunohistochemistrymaspin