Prescription regularity analysis in treating olfactory dysfunction from ancient Chinese medicine literature
- ZHU Jinxiang, ZHOU Min, WANG Ruizhi, LI Dan, FANG Caishan, CHEN Tengyu, LIN Manqing, RUAN Yan
Journal of Otolaryngology and Ophthalmology of Shandong University. 2023, 37(4):
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Objective Data mining method was used to analyze the prescription regularity of olfactory dysfunction recorded in ancient Chinese medicine literature. We aimed to provide a prescription reference for the way for treating olfactory dysfunction. Methods Traditional Chinese medicine(TCM)prescriptions from the Zhong Yi Dian Hai software for the treatment of olfactory dysfunction were retrieved, and the Excel 2016 software was utilized to form an olfactory dysfunction prescription database by importing the original data. Data were imported into the ancient and modern medical case cloud platform for prescription frequency, TCM frequency, TCM attributes, and TCM cluster, correlation, and complex network analyses. Results A total of 115 clearly recorded prescriptions were obtained, among which Xinyi San had the highest recorded frequency. In the TCM frequency statistics, the top 13 herbs included Asarum, Saposhnikovia divaricata, Ligusticum wallichii, Rattletop, Akebia quinata, Muskmelon pedicel, Radix angelicae dahuricae, Notopterygium root, liquorice, Prepared radix glycyrrhizae, Astragalus membranaceus, Ephedra, and Ginseng. It was found that warm, mild warm, and cold were the main characteristics among the four natures of herbs. Spicy, sweet, and bitter are the most common flavors among the five flavors of herbs. Lung and spleen meridians were the predominant meridians. According to data statistics, the most common uses for TCM include the following: dispelling wind and relieving pain, warming lungto reduce watery phlegm, dispelling wind and dispersing cold, and relieving stuffy nose. Three groups of TCM were obtained by conducting a cluster analysis of the top 10 TCM(I: Asarum and Muskmelon pedicel; II: Akebia quinata, Ligusticum wallichii, and Prepared radix glycyrrhizae; III: Rattletop, Saposhnikovia divaricate, Notopterygium root, Radix angelicae dahuricae, and liquorice). Correlation analysis was conducted by adjusting the confidence and support degrees to select 13 groups with the most relevant TCM compatibility, among which Rattletop, Saposhnikovia divaricata, Ligusticum wallichii, and Asarum were the most compatible. Based on the complex network analysis, nine core TCMs were obtained(Ligusticum wallichii, Asarum, Rattletop, Saposhnikovia divaricata, Akebia quinata, Radix angelicae dahuricae, Notopterygium root, Muskmelon pedicel, and liquorice), which functions in dispersing external evil and promoting clearance of nasal passages, the composition of which is similar to Xinyi San. Conclusion The ancient TCM treatments used for olfactory dysfunction are drugs for the diaphoretic drug, which is represented by the lung meridian of hand-taiyin and the spleen meridian of foot-taiyin. Moreover, attention should be paid to the etiology and pathogenesis of the disease and it should be determined whether the olfactory dysfunction was caused by the deficiency of Qi-Xue-Yin-Yang and qi deficiency so that treatment can be administered accordingly.