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    WANG Jia,YIN Jin-shu,PENG Hong
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1263)      PDF(pc) (263KB)(4392)       Save
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    ZHANG Hua,ZONG Shu,ZHANG Qing-quan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1196)            Save
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    XUE Wei-guo,SUN Jie,JIN Zheng,SHI Wen-bin,XIN Lu,LIN Guo-Jing,LI Jia-yun
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1676)            Save
    To observe the efficacy and safety of the levofloxacin ear drop in the treatment of otitis media. Method: A randomized, doubleblind, multicenter, ofloxacin ear drop controlled trial was performed. Results: The data of 120 patients were analyzed, and 60 patients were in the group of levofloxacin ear drop and the other 60 in the group of ofloxacin ear drop. Efficacy assessment based on symptom score reducing index showed that the efficacy rate of levofloxacin ear drop was 96.67% and that of the ofloxacin ear drop was 85.00%; the eradication rate of pathogens in the group of levofloxacin ear drop was 96.15% and in the group of ofloxacin ear drop was 95.83%. No significant difference was showed between two groups (both P<0.05). Conclusions: Levofloxacin ear drop is effective and safe in treating otitis media. The efficacy of levofloxacin ear drop is similar to that of ofloxacin ear drop.
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    FANG Xiao-ming
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract990)            Save
    To explore the effect of nasal endoscopy for pharyngeal bursitis. Method: Twelve cases of pharyngeal bursitis and eight cases of nasopharyngeal cyst were treated by nasal endoscopy, and 0.9% sodium chloride solution was given for nasal irrigation twice daily. Results: Twelve cases had complete response, six had partial response, and two had no response. The white scar fell off in 2 to 3 weeks. Conclusion: Nasal endoscopy is effective for pharyngeal bursitis.
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    WANG Li,LU Yong-hui
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1528)            Save
    To investigate the expression of telomerase activity and human telomerase reverse transcriptase(hTERT) in the nasal polyp tissues and their significance. Method: The expression of hTERT of 40 cases of nasal polyp tissues and 10 cases of normal inferior turbinate tissues was detected by immunohistochemical staining (PV9000 twostep kit). Results: The expression of telomerase in normal inferior turbinate tissues and nasal polyp tissues was 0 and 82.5%, respectively, and the difference was significant. The expression of telomerase had no significant correlation to the tumor grade, but had close correlation to the recurrence. Conclusion: The expression of telomerase is closely related with nasal polyp progression. It could be postulated that telomerase activity could be related with the tendency of polyp to recur.
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    WANG Hai-ying,CI Jun,FANG Ying,SHEN Guo-qin,GUAN Ye
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1125)            Save
    To explore the effect of nedocromil sodium on allergic rhinitis. Methods: Toluene 2,4 diisocyanate(TDI) was used to sensitize white rabbits as allergic rhinitis models, and nedocromil sodium was used to treat the disease. The changes in nasal mucosa were studied by pathological methods. Results: Symptoms of allergic rhinitis were remarkably relieved after nedocromil sodium treatment. Hematoxylin and eosin staining demonstrated that no edema was found in the nasal mucosa, and small vessels were normal after nedocromil sodium application; whereas edema, vasodilation and inflammatory cell infiltration were discovered in the control group. Conclusion: Nedocromil sodium has salutary effect on alleviating the symptom of nasal congestion, rhinorrhea and sneezing, and on reducing the sensory neuron sensitivity of the mucosa.
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    SHANG Guan han-jing,LI Zhi-chun
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1093)            Save
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    CHEN Yu-wu,GU Dong-sheng,WANG Tian-sheng,WU Chun-ping
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1269)            Save
    To observe the response of endoscopic surgery(ESS)for chronic sinusitis. Methods: A total of 468 patients with chronic nasal sinusitis: 106 of Ⅰtype, 228 ofⅡtype and 134 of Ⅲ type were enrolled in this study. Before operation, all had taken antibiotics, steroid and hormone. After operation, all were followed up and disposed of the crust cyst, small polyp and granulation tissue in time. Results: A total of 350 patients (74.79%)were cured, 96(20.51%)had response, and 22 (4.7%) had no response. The response rate was 95.3%. The main intraoperative complications were hemorrhage and injury of the orbital cavity, and the postoperative complication was adhesion of nasal cavity. Conclusion: ESS has advantages of less injury and good response. Sufficient preparation, operative technique, entire debridement of the focus, correct treatment for middle turbinate and prescriptive following up are the cores for preventing the complications and improving the response.
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    CHEN Shu-lin,WANG Jing-qing,FAN Yun-ping
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract998)            Save
    To review the diagnosis and treatment for otogenic tetanus. Methods: The diagnosis and treatment experience on a patient suffering from otogenic tenutas was summarized and the associated literatures were reviewed. Results: The patient was diagnosed as having otogenic tetanus precisely when his medical history and physical sign were investigated and examined carefully and cured eventually. Conclusions: If a patient with suppurative otitis media chews inconveniently and opens mouth difficultly following facial muscles dysfunction, the possibility of tetanus should be considered after the oromaxiallofacial region diseases are excluded.
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    Tympanic membrane indwelling catheterization under microscope for secretory otitis media following radiotherapy of nasopharyngeal carcinoma
    SHEN Fan,HUANG Ailan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1600)            Save
    Objective: To evaluate the effect of tympanic membrane indwelling catheter under microscope on secretory otitis media after radiotherapy for nasopharyngeal carcinoma. Method: Twentyseven cases(18 males and 9 females) were treated and followed up. Result: Nine(23.1%) out of 39 ears were cured, and the total efficiency rate was 87.2%(34/39). Conclusion: Tympanic membrane indwelling catheter under microspoce is a favorable way to straighten the eustachian tube function with weak damage.
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    SHI Li,SHI Bao-yuan,LI Xue-zong,XU Hao-jie
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1143)            Save
    To investigate the method and response of the dacrycystrhinostomy by nasal endoscopy for chronic dacryocystitis and obstruction of lacrimonasal duct. Method: Eight cases(10 sides) of chronic dacryocystitis and 2 cases of occlusion of lacrimonasal duct were dealt with the dacrycystrhinostomy by nasal endoscopy. Results: Followed up for 4 to 9 months, the symptoms were obviously released. Nine cases (11 sides) had been cured and 1 case (1 side) had response. The epithelization was in 3 months. Conclusion: The dacrycystrhinostomy by nasal endoscopy is an effective method with short operation and few injury.
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    Correlation between prognosis and increase of leucocyte count for the sudden hearing loss
    ZHANG Ming,ZHONG Gang-yi
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1886)            Save
    Objective: To study the correlation between the prognosis and leucocyte count in sudden hearing loss. Method: A total of 135 cases of sudden hearing loss were retrospectively analyzed. Results: The increase of leucocytes had no correlation with the auditory threshold volume(P>0.05). The curative rate in sudden hearing loss patients with normal leucocyte number was higher than that in patients with increased leucocyte and neutrophil peripheral leucocyte levels. Conclusion: The treatment efficiency for patients with sudden hearing loss with increased leucocyte level is higher than that for patients with normal leucocyte level.
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    CUI Hong,ZHAO Shu-you,ZHANG Qing-quan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1620)            Save
    Objective: To investigate the expression of oncogene STK15 in laryngeal squamous cell carcinoma(LSCC), and therefore to find out the correlation of STK15 and laryngeal squamous cell carcinoma. Methods: SP immunohistochemical method was used to determine the expression of STK15 in 40 cases of LSCC and 30 cases of vocal cord polyp. Results: STK15 was found in 67.5%(27/40)and 33.3%(10/30)of LCSS and vocal cord polyp, the difference was significant(P<0.05). Expression of STK15 had some relation with the tumor grade and lymphatic metastasis(P<0.05), but not with the pathology grade, primary site of LSCC, patients′gender and age. The degree of STK15 expression was related with the tumor grade(P<0.05). Conclusion: STK15 may play an important role in the pathway of carcinogenesis and progression of LSCC and it may be identified as a new therapeutic target.
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    XIE Zhi-gang,ZHANG Xi-ying
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1414)            Save
    To investigate the prevention and management of postoperative nasal cavity adhesion in children with sinusitis. Method: The clinical data of 402 children with sinusitis underwent functional endoscopic sinus surgery in our hospital were analyzed. Results: During a followup for more than 6 months, postoperative nasal cavity adhesions were found in 64 patients (82 sides), of which 56 patients (71 sides) were successfully separated by once and 8 patients (11 sides) by many times. The reasons of adhesion were analyzed. Conclusion: The reasons of the nasal cavity adhesions are as follows: rude and improper management on the abnormal anatomy structures in operation, not followed up in time, and using drugs improperly after operation. The prevention and early separation of the postoperative nasal cavity adhesions play important role in improving the curative effect for endoscopic sinus surgery.
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    XIANG Jun,WANG Tian-sheng,GU Dong-sheng,ZENG Dong-qian
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1018)            Save
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    Modified nasal septum modification
    ZHAO Shen-lin,DUAN Li-hua,SONG Dao-liang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1199)      PDF(pc) (206KB)(1895)       Save
    Objective: To evaluate the clinical outcome of modified nasal septum modification for nasal septum deviation. Methods: One hundred and twentysix patients with nasal septum deviation were treated in our hospital. In the operation, the original structure was saved, the deviated nasal septum was modified by resection or fracture, and the hypertrophic inferior turbinate was moved outside by fracture. Results: Nasal septum deviation was successfully corrected with satisfactory ventilation in both sides of the nasal cavity; no perforation or flop of nasal septum occurred in any case. Conclusion: The modified nasal septum modification is safe for teenagers and is an effective method with the advantage of easy manipulation.
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    YU Yun-hong,CAI Xiao-lan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1164)            Save
    To discuss the treatment of refractory nasal bleeding under nasal endoscopy. Methods: Nasal endoscopy, electrocoagulation and stuffingup were performed in 60 cases of refractory nasal bleeding under local anesthesia and in 7 cases under general anesthesia. Results: Refractory bleeding mainly happened at the nasal septum of olfactory cleft region and the posterior part. All the patients were cured under nasal endoscopy. Conclusion: Nasal endoscopy is effective in looking up the bleeding points and electrocoagulation is effective in treating the bleeding.
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    JIANG Xian,JIN Yong-de,BAI Shang-jie,CUI Chun-lian,JIN Shun-ji
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1100)            Save
    To explore an effective treatment method for children′s epistaxis from Kiesselbach′s plexus. Method: Xiao zhiling was injected under mucosa to 126 children with epistaxis. Result: Ninetyfour patients were cured by once injection; 28 by 2 or 3 times; and the other 4 being of no effect were cured by Nd: YAG laser under general anesthesia. Conclusion: Injection of Xiaozhiling under mucosa is effective, safe and acceptable for children with epistaxis.
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    Huiwei,FAN Xian-liang,WANG Zhe,ZHANG Hui,JIAN Jing-fen
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1436)            Save
    Objective: To observe the effect of azelastine hydrochloride and fluticasone propionate nasal spray in treatment of allergic rhinitis. Methods: One hundred and nine patients (mean 35.6 yearslod, ranged from 15 to 76 yearslod) with persistent allergic rhinitis were randomized into mild, moderate or severe groups according to the ARIA. Patients of mild group received azelastine hydrochloride or fluticasone propionate one spray per nostril, two times per day for 30 days. Patients of moderate or severe group received azelastine hydrochloride or fluticasone propionate (with a 30minute interval), or their combination. Results: The effect in mild group was not significantly different between azelastine hydrochloride and fluticasone propionate(86.36% vs 92.00%, P>0.05). In moderate or severe groups, the response rate was 66.67%, 73.33% and 96.88% in azelastine hydrochloride (the first group), fluticasone propionate alone(the second group) and their combination (the third group). There was no significant difference between the first and the second groups(P>0.05). The response rate of the third group was significantly higher than that of the first and the second groups(both P<0.05). There was no significant difference between the total response rate of azelastine hydrochloride and of fluticasone propionate (83.78% vs 90.00%, P>0.05). Conclusion: Azelastine hydrochloride and fluticasone propionate can be used for the firstline pharmacological treatment of allergic rhinitis, and their combination can be used to treat moderate or
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    GUO Zhi-yong,ZHANG Wen-hua,ZHANG Yu-geng,LIN Peng
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1537)            Save
    To explore the differences of polysomnography parameters of obstructive sleep apnea hypopnea syndrome (OSAHS) between children and adults. Methods: The sleep of 37 pediatric OSAHS and 35 adult OSAHS patients was monitored. Several parameters, including the apnea index(AI), hypopnea index(HI), apnea hypopnea index(AHI), the lowest oxygen saturation(LSaO2) and the longest apnea time were counted, and the percent of stages of NREM and REM, including the microarousal index was calculated. Results: Many parameters, such as AI, HI, AHI, LSaO2 and the longest apnea time were significantly different between the two groups. The sleep structure of pediatric OSAHS was similar with that of normal children, but different from that of the adult group. Conclusion: The difference of PSG parameters is significant between pediatric OSAHS and adult OSAHS. The standard of adult PSG does not fit for child PSG.
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    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1525)            Save
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    Construction of RNAi expressing plasmid vector of pSIRENshuttle for EGFR gene silencing
    LUAN Jiangang,LIANG Chuanyu,WEN Yanjun,LI Jiong
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1709)            Save
    [ABSTRACT]Objective: To construct an expressing vector (pSIRENShuttleEGFR ) of RNAi in order to suppress gene expression of epidermal growth factor receptor (EGFR). Methods: Three 69 basepair oligos coding hairpin RNA which specifically aimed at EGFR gene were chemically synthesized and annealed, then inserted into the downstream of U6 promoter of vector to construct RNAi plasmid (pSIRENShuttleEGFRs). Sequence analysis was used to identify the correction of recombinant vector. RT-PCR was performed on the CNE cell line transfected by pSIRENShuttleEGFRs. Results: Sequencing analysis demonstrated that 69 bp had been inserted into expected site and the insertion sequence was exactly correct in recombinant pSIRENShuttleEGFRs vectors. It was showed that usingthe plasmid vector pSIRENEGFRs to induce RNAi suppressed the expression of endogenous EGFR in CNE human nasopharyngeal epidermal carcinoma cells. As a consequence, the mRNA of EGFR was decreased. Conclusion: RNAimediated inhibition of EGFR gene induced by shRNA expressing plasmid vector may constitute a useful approach in the treatment of human nasopharyngeal epidermal cancer.
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    Trachobronchial foreign bodies in adult patients: a retrospective analysis
    LIU He,ZHANG Li-qiang,HE Hai-xian,SUN Rui-jie,XU Hao-jie,WANG Xue-hai,CHEN Cheng-fang,ZHANG Hai-yan,LI Xue-zhong
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1438)      PDF(pc) (262KB)(1844)       Save
    Objective: To investigate the clinical characteristics and experiences of trachobronchial foreign bodies in adult patients. Methods: The clinical data of 30 cases admitted between October 1996 and May 2006 were retrospectively analyzed. The foreign bodies were varied and mainly were dentures and plants. Results: In one case the foreign body was taken out by direct laryngoscopy, three cases were subjected to emergency tracheotomies, four cases were subjected to rigid bronchoscopies and tracheotomies and the other 22 cases were subjected to rigid bronchoscopies. Conclusion: Trachobronchial foreign bodies are able to be successfully taken out based on their kinds and positions.
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    ZHOU Bin,XU Ping,TANG Yong
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1215)            Save
    To investigate the influence of hearing impairment on the prognosis of sudden sensorineural hearing loss(SSHL). Method: A total of 146 cases(167 ears) were studied by SAS system on the degree of hearing impairment with prognosis. Results: An initial audiometric curve of complete deafness and a worse highfrequency(4?000?Hz and 8?000?Hz) hearing level, and a difference between high(4?000?Hz+8?000?Hz) and low(250?Hz+500?Hz)frequence revealed a bad prognosis. Multivariate analysis showed that the 8?000?Hz hearing level at the initial visit most influenced the prognosis, following the 4?000?Hz hearing level and the type of the audiometric curve. Conclusion: Results from different statistical analysis reveal that the unification of the diagnosis and therapeutic efficiency as well as the application of the multiple factors regression analysis are essential for the research on SSHL.
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    CHEN Xiu-mei,LUAN Xin-yong,ZHANG Qing-quan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1372)            Save
    To investigate the effect of three nasal packing materials in functional endoscopic sinus surgery. Methods: Seventyfive patients with chronic rhinosinusitis and nasal polyp were treated with functional endoscopic sinus surgery. After surgeries, voseline strips gauze, Merocel and RapidRhina were used at random and were taken out 4872 hours later. Results: About 80% of the patients in group of voseline strips gauze felt pain, 60% of them still had bleeding after being taken out the nasal packings; about 60% of the patients in group of Rapidrhina felt pain, and 12% of them had bleeding after being taken out the nasal packings; 44% of the patients in group of Merocel felt pain, and 24% of them had bleeding after being taken out the nasal packings. Conclusions: All the three nasal packing materials have good effect. Voseline strips is cheap but brings much pain to the patients, while Merocel and Rapidrhina makes patients feel comfortable but is expensive.
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    Postnasal drip syndrome in 300 cases
    LI Jia,LI Duo-xian,CHEN Kai, YE Bao-xiang,ZHANG Zhi-xiong,LI Xiong-wen,YE Yuan-hang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1782)      PDF(pc) (275KB)(1825)       Save
    ObjectiveTo study the etiopathogenisis and clinical manifestations of postnasal drip syndrome. MethodsThe clinic manifestations, treatments and follow-up results of 300 cases in our hospital in recent years were retrospectively analyzed. Postnasal drip is mainly complicated with sinus nasalis and nasopharynx diseases and it often induces chronic cough and various kinds of discomforts in the pharyngeal portion. ResultsAll cases mainly had chronic and various kinds of discomfort in the pharyngeal portion related to sinus nasalis and nasopharynx diseases. Of the total, 243 cases related to diseases in the nasal cavity and the sinus nasalis, of which rhinitis happened in 30, periodic rhinitis in 59, nasosinusitis in 64, nasosinusitis polypus in 77 and tumor in the nasal cavity and the sinus nasalis in 13. Also, 57 cases related to nasopharynx diseases, including 50 cases of inflammatory diseases and 7 cases of neoplastic diseases. The misdiagnosis rate was up to 78.7 percent. After anti-infective treatment, anti-allege, necessary surgeries and radiotherapies, the cough symptoms of 290 cases disappeared and of 10 cases apparently improved. During a 1-2 year follow-up, 8 cases relapsed, but the same treatment measures still had an effect. ConclusionsStrengthening the knowledge of postnasal drip syndrome is an important step to diagnose, reduce the rate of misdiagnosis and guide therapy. In order to reduce the misdiagnosis rate, it is necessary to use the standard check. Also the all-round treatments according to the causes are guarantees for curative effects.
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    WEI Yu-mei,CAI Xiao-lan,ZHAN Guo-li,WANG Tian-duo
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1354)            Save
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    Therapeutic efficacy of nonoperation for chronic sinusitis in children:A multifactor analysis
    ZHENG Gui-liang,YU Ya-ping,ZHU Yu-hua,ZHAI Suo-qiang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1052)            Save
    To investigate the factors influence in the nonoperation therapeutic efficacy for chronic sinusitis in children. Method: Logistic regression analysis was performed for sex, age, case history, sinusitis stage, involved sinus number, adenoid hypertrophy, allergic rhinitis, puncture antral and course of treatment in 58 patients treated with combined therapy. Result: Case history, adenoid hypertrophy, allergic rhinitis and course of treatment were the important factors influenced the nonoperation therapeutic efficacy. Conclusion: Full dose and course of treatment should be applied to children with chronic sinusitis, and adenoid hypertrophy and allergic rhinitis should be treated actively.
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    LI Zhen-cai,FENG jie,ZHANG Xin-fang,PENG Xiu-hua,YOU Mei
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract869)            Save
    To study the response of dexamethasone injection in the middle ear for sudden deafness. Methods: Thirty patients were randomly divided into two groups. Both groups were given common medicines including gingkgo, coenzyme A, inosine and vitamine B, and the experiment group was given dexamethasone in the middle ear. Results: The total response rate was 46.66% and 77.78% in the control and experiment groups, respectively (P<0.05). Conclusion: Dexamethasone injection in the middle ear is good for sudden deafness.
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    ZHANG Qiu-gui,HE Hai-yan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1245)            Save
    To discuss the types of allergens and provide an instruction for prevention and immunotherapy of allergic rhinitis. Method: A total of 856 patients with allergic rhinitis were enrolled, and skin prick test was used in this study. Result: The main allergens were house dust mite and dermatophagoides farinae, and the positivity ratios were 59.5% and 57.9% respectively. Conclusion: Knowing the allergens provides an instruction for prevention and immunotherapy of allergic rhinitis.
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    SONG Xi-cheng,ZHANG hua,ZHANG Qing-quan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1225)            Save
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    LI Yu-guang,SONG Xiao-ping
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1042)            Save
    To summarize the experience of dacryorhinocystotomy with nasal endoscopy for chronic dacryocystitis. Methods: Endoscopic dacryorhinocystotomy was performed for 90 patients (105 eyes) with chronic dacryocystitis or nasolacrimal duct obstruction from August 2000 to December 2004. EC biosythesis earbrain glue was used for 72 eyes; epidural tube for 10 eyes; silver clip for 13 eyes; and injector nipple for 5 eyes. Simultaneously, high deviation of nasal septum was corrected in 7 patients; hypertrophic uncinate process was excised in 10 patients; polypous middle turbinate was excised in 9 patients; and polyp was excised in 6 patients. Results: Ninetytwo eyes were cured, 8 had effective; and 5 had no effect. The response rate was 95.24%. Conclusion: The ways of dealing with anastamosis should be chosen according to operator′s experience and dacryocyst mucosa.
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    SHEN Xiao-hui,GAO Xia,YU Cheng-jie,CHEN Feng
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1671)            Save
    [ABSTRACT]Objective: To evaluate the surgical methods and prognosis of glottic carcinoma originating from posterior commissure of vocal cord. Methods: Eight patients with glottic carcinoma originating from posterior commissure were enrolled in this study. Of them, 3 cases of TisN0M0 were operated on with selfretaining laryngoscope, 3 cases of T1M0N0 and 2 cases of T2N0M0 were dealt with partial laryngectomy and the laryngeal defects were reconstructed by bipedical sternohyoid muscle flap. Results: After a followup over 5 years, 8 patients were extubated successfully and could speak and take food by mouth freely; 2 patients had cervical lymph node metastasis in the same side and 3 recurred including 1death without therapy. Conclusion: Compared with general glottic carcinoma, the recurrence rate and the cervical lymph node metastasis rate of carcinoma originating from posterior commissure are high significantly. Neck dissection in the same side would be necessary for tumor not in situ and the cutting edge should be over 5 mm away from the tumor. Bipedical sternohyoid muscle flap is credible for the laryngeal defects.
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    SUN Zhen-feng,MENG Qing-hong,DONG Pin
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1168)            Save
    To explore the relation between allergen reaction and the pathogenesis of irritability rhinitis and bronchus asthma. Method: Skin prick test was performed in 100 cases of irritability rhinitis and 100 cases of bronchus asthma. Result: Inhalational and edible allergen, especially the dermatophagoides pteronyssinus and the dermatophagoides farinae were significantly higher in bronchus asthma than in irritability rhinitis. Conclusion: The reaction degree for allergen may have some relation with the pathogenesis of diseases, and so forepart prevention for irribility rhinitis is necessary.
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    Surgical opportunities on facial nerve decompression following intra-temporal facial nerve injury: an experimental study
    LUO Jian-fen,FAN Zhao-min,WANG Hai-bo
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1649)      PDF(pc) (235KB)(1796)       Save
    To establish animal models of intratemporal facial nerve injury and find the natural developmental features of facial nerve injury. To explore the best time to do facial nerve decompression surgeries and to discover the laws of injured facial nerve recovery after the decompression surgeries. Methods32 200~300g female Wister rats were used, and the tympanic segments of the bone canal of the facial nerves were compressed by minimal forceps. After making the models, rats were randomly divided into 4 equal groups which were given decompression surgery at different times: within 3 weeks group, after 4 weeks group, after 8 weeks group and the control group. In the control group nothing was done. Decompression consisted of removing the crushed bone pieces and incising the epineurial sheath at the abovementioned times. The facial nerve threshold current was measured using the NIMResponse to observe the recovery of the facial nerve at intervals of 4 weeks. ResultsThe complete paralysis rats had no response to the maximal current (3mA) in the first week. No significant difference was found between the control group and the group which had decompression surgery after 8 weeks(P>0.05), but a difference between the other groups and the control group was found(P<0.05). There were significant differences among the three surgery groups(P<0.05). ConclusionsCrushing the facial nerve bone canal by minimal forceps is a reasonable method to make the animal models of intratemporal facial nerve injury. Decompression of the facial nerve performed within two months resulted in a faster recovery of the threshold current. Decompression later than two months had the same recovery speed as no decompression of the facial nerve. During the first two months, the earlier the decompression of the facial nerve was performed, the faster the facial nerve recovered.
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    LIU Bing,WU Jian
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1016)            Save
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    LUO Xin-an,SUN Zheng-liang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1082)            Save
    To investigate the characteristics of ambulatory blood pressure in the patients with obstructive sleep apneahypopnea syndrome(OSAHS). Methods: With the use of polysomnography, 112 snorers were examined and divided into OSAHS and non OSAHS groups. Meanwhile, with the use of continuous Holter ECG and blood pressure (Bp) measurement, the daytonight rhythm of Bp was compared between two groups. Result: There were significantly higher incidence of hypertension and disappearance of daytonight rhythm of Bp in OSAHS group than in nonOSAHS group. Conclusion: OSAHS can induce hypertension and disappearance of daytonight rhythm of Bp.
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    LI Hai-yan,ZHAO Qiu-liang,HAN Xiao-pan,YU li
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1413)            Save
    To investigate the relationship between superoxide dismutase( SOD ) and malondialdehyde( MDA ) and obstructive sleep apnea hypopnea syndrom (OSAHS) accompanied by hypertension. Methods: Thirtyone OSAHS patients without hypertension, twentynine OSAHS patients with hypertension and twentyfive healthy controls were enrolled in this study. The levels of MDA and SOD were measured respectively by thiobarbituric aicd and xanthine oxidese method. Results: Compared with the healthy controls, the level of SOD in OSAHS patients was decreased and the level of MDA increased. The SOD/MDA ratio in the OSAHS patients with hypertension decreased significantly, and it negatively correlated with the apnea hypopnea index (AHI) and the longest duration of apnea/hypopnea and positively correlated with the lowest oxygen saturation. Conclusion: The maladjustment of SOD/MDA ratio may play an important role in the occurrence of OSAHS with hypertension.
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    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract871)      PDF(pc) (267KB)(1794)       Save
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    GU Dong-sheng,WANG Tian-sheng,CHEN Yuwu,XIANG Jun,WU Chun-ping
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1218)            Save
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    YANG Huai-an,WANG Yan,YANG Ning,LI Xiao-tian,MA Jie
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1236)            Save
    Objective: To explore the effect of the modified uvulopalatopharyngoplasty (UPPP) preserving the uvula. Methods: Twentyeight patients with obstructive sleep apnea syndrome (OSAS)who had been confirmed by PSG in our hospital from 2003 to 2005 were involved in this study. The modified UPPP preserving the uvula completely was taken under general anaesthesia. Results: The preserved uvula contracted 2 weeks after the UPPP. The pharyngeal cavity behaved young 3 months after operation. No vulopalatal insufficiency occurred. The response rate was 100% based on the questionnaire investigation and PSG detection. Conclusion: The modified UPPP is more effective for OSAS than the normal UPPP by increasing the nasopharyngeal and oropharyngeal cavity and avoiding vulopalatal insufficiency.
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    Revision endoscopic sinus surgery on chronic sinusitis and polyps
    ZHENG Guojun,TONG Shuhong,WANG Qiaofang,YANG Dun
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1804)            Save
    [ABSTRACT]Objective: To explore the effect of reoperation for recurrent sinusitis and polyps. Methods: Reoperation by endoscope was performed in 46 patients, of which Messerklinger′s technique was used in 32, and Wigand′s technique was used in 14. Results: Reoperation was successful in 39 patients (78.3%), but not in 10 (21.7%). Complication was found in 1 patient. Conclusion: Revision endoscopic sinus surgery is effective for recurrent sinusitis and polyps. CT scanning has salutary effect for reducing complications.
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    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1801)            Save
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    Treatment of maxillary sinus polyp and cyst by microwave under endoscopy
    ZHANG Wei,LIU Ning,LI Ming-yue
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1088)            Save
    To discuss a simple and convenient surgical method in use of microwave to treat the maxillary sinus polyp and cyst. Method: A total of 67 patients were treated with microwave coagulating through enlarged ostium guided by 30° or 70° endoscopy, and patients need ostium enlarged simultaneously were performed endoscopic middle meatal antrostomy by microwave. Result: The cure rate was 98.5% after 6~12 months (average 9 months) followup. Conclusion: Maxillary sinus polyp and cyst might be cured by endoscope and microwave treatment.
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    XING Li-jun,ZHANG Zhong-hua,DING Ji-jiang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1058)            Save
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    MA Wen-xin,HUANG Xiao-yang,LU Xin-feng,YANG Xue-hua
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1117)            Save
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    QIAO Xiu-jun,LI Jian-sheng,MOU Shan-yu,HUANG Yong-mei
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1583)            Save
    To explore the prognosis of otitis media with effusion in children after treatment by microwave. Methods: The data of 152 children suffering from otitis media with effusion from October 2003 to October 2005 were analyzed retrospectively. The children were divided into microwave group (78 cases, 86ears) and control group (74 cases, 84 ears). Microwave group was divided into three subgroups according to disease course and two subgroups according to patients′ age. Results: The total response rate was 75.6% in the microwave group and 51.2% in the control group (P<0.01). In the microwave group, there were significant differences in the two kinds of subgroups. Conclusion: Microwave is of value for the prognosis of otitis media with effusion in children, and the shorter the disease course is, the better the curative effect is, especially in younger children.
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    WANG Jian-guo,HAN Zhen-qiang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1426)            Save
    To summarize the experience of treatment for tympanosclerosis. Methods: The clinical data of 25 cases of tympanosclerosis undergoing tympanoplasty from November 2001 to February 2005 were retrospectively analyzed. Tympanoplasty of grade Ⅰwas performed on all patients. In the operation, temporal fascia was used to repair the drum and self cortex of mastoid bone or artificial porcelain auditory ossicles were used to reconstruct the ossicular chain. Results: The lesion intruded into drum, promontory of tympanum, incudomalleus, stapes and its surroundings, and no cholesteatoma accompanied by. After operation, the hearing upregulated by 15?dB(96%) in 24 patients and vertigo was found in 4. Conclusions: To clear a sclerotic region around the stapes and to reconstruct ossicular chain and tympanic membrane are the key points of success. The response is closely related with the sclerotic region around the ossicular chain.
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    Etiology of accessory auricles in embryos
    CHEN Jin-Hua
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2009, 23 (3): 28-29.  
    Abstract860)      PDF(pc) (190KB)(1768)       Save

    Objective  To investigate etiology of accessory auricles in the embryos. Method  The proportion of various accessory auricles was calculated. Results   97% of the deformities were near the ear screen,98% of the patients had no other deformities on the jaw,neck and face. 89% of the accessory auricles occurred only on the right or left side of the face. Conclusion  Accessory auricles come from the first gill bow of the human embryos. Most of the patients have no other deformities on the jaw, neck and face. Most of the accessory auricles occur only on the right or left side of the face.

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    ZHOU Yi-de,ZHENG Hong-liang,SHEN Xiao-hua,ZHOU Rong-jue,LIU Feng,ZHANG Ru-xin
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1070)            Save
    To study the changes of blood pressure in patients with nasal obstruction accompanied by persistent hypertension after nasal endoscopic surgery (NES). Methods: Nasal endoscopic surgery was performed on 58 patients. The blood pressure was detected before operation, two weeks and six months after operation. Results: The systolic pressure before operation, two weeks and six months after operation was (164.5±63.1)mmHg,(143.0±51.6)mmHg and (141.0±59.8) mmHg; the diastolic pressure was (96.0±52.3) mmHg,(82.2±38.4)mmHg and (80.4±41.5) mmHg respectively. Both systolic and diastolic blood pressures were lower two weeks and six months after operation than before operation (P<0.01). Conclusion: NES as an assistant method is effective for controlling blood pressure of the patients with nasal obstruction accompanied by persistent hypertension.
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