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    WANG Jia,YIN Jin-shu,PENG Hong
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1921)      PDF(pc) (263KB)(4587)       Save
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    Complications and treatment of UPPP
    ZHANG Hua, ZHANG Qing-quan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (1): 12-14.  
    Abstract2118)      PDF(pc) (983KB)(3469)       Save
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    Cited: Baidu(1)
    Efficacy of recombinant human epidermal growth factor in prevention of radioactive oral mucosa inflammation and acute radiation dermatitis for nasopharyngeal carcinoma.
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (1): 95-99.   DOI: 10.6040/j.issn.1673-3770.0.2016.203
    Abstract1634)      PDF(pc) (962KB)(3361)       Save
    Objective To observe the efficacy of recombinant human epidermal growth factor(rhEGF)in prevention of radioactive oral mucosa inflammation and acute radiation dermatitis of nasopharyngeal carcinoma(NPC). Methods A total of 50 NPC patients(5 stage Ⅱ, 32 stageⅢ and 13 stage Ⅳa)in the department of radiation oncology of our hospital hospitalized from January 2014 to December 2015 were randomly divided into the experimental group(n=26)and the control group(n=24).The two groups were treated with intensity modulated radiation therapy on the whole course, 6 weeks a radiotherapy cycle. The control group was given cisplatin single agent chemotherapy, and every 7 days for a cycle, 5 to 6 cycles. On the basis of the treatment of the control group, the experimental group was treated with combination of rhEGF(oral spray and neck skin smear gel)in the same period of the treatment. Short-term efficacy of the two groups was evaluated with complete remission, partial remission, stable disease and progression disease. The toxicity and side-effects were evaluated by the National Cancer Institute Common Toxicity Criteria(NCI-CTC). Results The short-term efficacy of the two groups was basically equivalent(P>0.05). No patients died in the two groups due to the toxic side effects, and the main toxicities in the two groups were gastrointestinal toxicity, myelosuppression and abnormal liver function. All patients had happened radioactive oral mucosa inflammation and acute radiation dermatitis of the neck which level was over grade Ⅰ. The incidence of radioactive oral mucosa inflammation and acute radiation dermatitis of the neck over grade Ⅱ level in the experimental group(42.31% and 11.54%)were significantly lower than those of the control group(70.83% and 41.67%)(P=0.042, 0.035). Conclusion The method of combination radiotherapy and chemotherapy with rhEGF in the treatment of NPC can effectively reduce the incidence of 山东大学耳鼻喉眼学报31卷1期 -于斌,等.重组人表皮生长因子预防鼻咽癌放射性口腔黏膜炎和急性放射性皮炎的疗效观察 \=-toxicity and side-effects of radioactive oral mucosa inflammation and acute radiation dermatitis of neck which caused by radiotherapy and chemotherapy.
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    Balloon catheter dilation technology in combination with fibrolaryngoscope in treating sinus cyst
    XIAO Jian-xin, CHEN Rui-kai, HE Bi-yi, CHEN Wei-xiong, WANG Yue-jian
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (4): 46-48.  
    Abstract1379)      PDF(pc) (1073KB)(3348)       Save

    Objective   To evaluate the effect of nasal endoscopic sinus surgery and balloon catheter dilation technology in combination with fibrolaryngoscopy in treating sinus cyst. Methods   The clinical data of 14 cases (19 maxillary sinuses, 3 frontal sinuses) using the balloon catheter dilation technology in combination with fibrolaryngoscopy (the balloon group) and 16 cases (23 maxillary sinuses, 8 frontal sinuses) using conventional nasal endoscopic sinus surgery (the conventional group) were retrospectively analyzed. Visual analog scale (VAS) was used to record operative difficulty grade and operation time. Nasal endoscopy, coronal sinus CT scanning, Lund-Kennedy endoscopy and Lund-Mackay CT scan staging scores were used to evaluate the post-operative prognosis. Results   The balloon group was longer in operative time than the conventional group (P<0.001). During follow-up periods of  8 and 24 weeks after the operation, the sinus ostia were patency, and the nasal cavities recovered well. Conclusion   In the sinus cyst operation, the balloon group and the conventional group  equally  achieve good curative effects. In the balloon group, the nasal cavity and sinus structures can be preserved with  minimal invasion, but the operation is more difficult and longer than those in the conventional group, due to the fibrolaryngoscope.

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    Analysis of the effect of Professor Xie Hui using warm needling therapy for allergic rhinitis.
    DOU Dou, LI Linglong, ZHANG Jin, CAO Liu, XIE Hui
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (4): 60-62.   DOI: 10.6040/j.issn.1673-3770.0.2016.225
    Abstract1358)      PDF(pc) (943KB)(3337)       Save
    Objective To analyze the principle of the Warm Needling therapy for allergic rhinitis(AR). Methods From March 2013 to September 2015, a total of 36 patients with AR were treated by using needling on points of Xiaguan(ST7),Hegu(LI4),Baihui(DU20)and warm needling on Zusanli(ST36), once a week, three times as a course of treatment. Results There were 5 patients got significant results, 27 got marked effects, and 4 failed,the efficient was up to 89%. Conclusion By Inquiry the results and analysis the treatment, we conclude the principle of AR to be “tonify spleen Qi, ascending Yang and defending weiqi.”
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    One-stage nasal surgery and uvulopalatopharyngoplasty for obstructive sleep apnea-hyponea syndrome
    PANG Tai-zhong, WU Yun-gang, LI Xiao-yu, MA Lin-xiang, DING De-tao, HUANG Meng-meng, WANG Cai-hua, ZHANG Yong-hong, ZHANG Hui
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (3): 7-9.  
    Abstract971)      PDF(pc) (943KB)(2725)       Save

    Objective   To investigate the clinical efficacy of uvulopalatopharyngoplasty(UPPP) with nasal surgery for patients with obstructive sleep apnea-hypopnea syndrome(OSAHS). Methods   40 OSAHS patients were divided into the A or B group, in which group A underwent UPPP with nasal surgery, which group B underwent only UPPP. The clinical results and the average apnea-hypopnea index (AHI) before and after the operation were compared. Results   The average AHI were all decreased, however, the result of group A was better than the group B 6 months after the operation. Conclusion   UPPP with nasal  surgery is an available and relatively safe surgical approach for the OSAHS patients with nasal obstruction.

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    Relationship between Friedman OSA staging and ZPPP plus GAHM
    SUN Xiao-qiang1, YI Hong-liang2, CAO Zhen-yu2, ZHANG Yu-jun2
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (6): 8-9.  
    Abstract1803)      PDF(pc) (1023KB)(2631)       Save

    Objective To explore the relationship between Friedman OSA staging and genioglossus advancement and hyoid suspension(GAHM) plus Z-palatopharyngoplasty(ZPPP). Methods 26 patients with severe OSAHS (AHI>40)were performed GAHM plus ZPPP. The obstructive sites were identified in both oropharynx and hypopharynx. The follow up lasted at least 6 months postoperatively. The Chi square test was used to compare the preoperative and postoperative results. Results Satistying clinic results for the patients with Friedman OSA stages Ⅱ were 100%, while the overall success rate of Friedman OSA stages Ⅲ was 22.2%. Conclusion ZPPP plus GAHM is an effective method for patients with Friedman OSA stages Ⅱ.

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    Postnasal drip syndrome in 300 cases
    LI Jia,LI Duo-xian,CHEN Kai, YE Bao-xiang,ZHANG Zhi-xiong,LI Xiong-wen,YE Yuan-hang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract3524)      PDF(pc) (275KB)(2595)       Save
    ObjectiveTo study the etiopathogenisis and clinical manifestations of postnasal drip syndrome. MethodsThe clinic manifestations, treatments and follow-up results of 300 cases in our hospital in recent years were retrospectively analyzed. Postnasal drip is mainly complicated with sinus nasalis and nasopharynx diseases and it often induces chronic cough and various kinds of discomforts in the pharyngeal portion. ResultsAll cases mainly had chronic and various kinds of discomfort in the pharyngeal portion related to sinus nasalis and nasopharynx diseases. Of the total, 243 cases related to diseases in the nasal cavity and the sinus nasalis, of which rhinitis happened in 30, periodic rhinitis in 59, nasosinusitis in 64, nasosinusitis polypus in 77 and tumor in the nasal cavity and the sinus nasalis in 13. Also, 57 cases related to nasopharynx diseases, including 50 cases of inflammatory diseases and 7 cases of neoplastic diseases. The misdiagnosis rate was up to 78.7 percent. After anti-infective treatment, anti-allege, necessary surgeries and radiotherapies, the cough symptoms of 290 cases disappeared and of 10 cases apparently improved. During a 1-2 year follow-up, 8 cases relapsed, but the same treatment measures still had an effect. ConclusionsStrengthening the knowledge of postnasal drip syndrome is an important step to diagnose, reduce the rate of misdiagnosis and guide therapy. In order to reduce the misdiagnosis rate, it is necessary to use the standard check. Also the all-round treatments according to the causes are guarantees for curative effects.
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    Methods for exposure of the facial nerve in parotid gland surgery.
    WANG Xiaoxia, YAO Xiaobao, LI Honghui, BAI Yanxia, ZHANG Shaoqiang, SHEN Zhen, LI Baiya
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (4): 48-50.   DOI: 10.6040/j.issn.1673-3770.0.2015.028
    Abstract2311)      PDF(pc) (914KB)(2476)       Save
    Objective To explore the parotid gland surgery in a safe and efficient way to expose the facial nerve. Methods A total of 810 benign parotid gland cases were retrospectively analyzed, they were respectively treated by the methods of total trunk, zygomatic branch, mandibular margin and buccal branch to locate the facial nerve. Results A total of 465 cases were treated by the total tunk method, 11 cases of them were not found with this method and then were found with other methods, and 3 cases of them were injuried the facial nerve trunk; 138 cases were exposured the facial nerve successfully with the zygomatic branch method; 74 cases were exposured successfully with the mandibular margin method, 8 cases of them had intra-operative injury; 133 cases were exposured successfully with the buccal branch method, 5 cases of them had intra-operative injury. Conclusion Parotid gland surgery at a fixed anatomic mark is good at searching the facial nerve. In according to the actual circumstances of the patients, surgeons should use comprehensive methods to expose the facial nerve in a safe and quick way.
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    Interpretation of “The Third Edition of the International Classification of Sleep Disorders(ICSD)”.
    SHANG Wei
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (5): 18-20.   DOI: 10.6040/j.issn.1673-3770.0.2016.386
    Abstract3466)      PDF(pc) (1002KB)(2444)       Save
    The third edition of the International Classification of Sleep Disorders(ICSD-3)is the key reference for the diagnosis of sleep disorders. ICSD-3 is built on the same basic outline as ICSD-2, preserving the major diagnostic classifications. Significant modifications have been made to the nosology of insomnia, narcolepsy, and sleep-related breathing disorders. Major changes of the manual are reviewed in this article.
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    ZHANG Hua,ZONG Shu,ZHANG Qing-quan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1843)            Save
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    Detection of serum total IgE and allergen-specific IgE in healthy adults and its significance.
    YUAN Yuan, WU Zhongfei, CHAO Changjiang, LU Meiping, TIAN Huiqin, CHENG Lei
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (4): 34-38.   DOI: 10.6040/j.issn.1673-3770.0.2016.259
    Abstract4359)      PDF(pc) (1217KB)(2319)       Save
    Objective To explore the scientific significance and practical application of serum levels of total IgE(tIgE)and allergen-specific IgE(sIgE)in excluding allergen sensitization. Methods A total of 536 volunteers including 347 males and 189 females, aged 19-60 years with median age of 38 years old received the healthy physical examination were recruited in the study. All the subjects had no history and symptoms of allergic diseases as well as systemic diseases. Serum tIgE was detected by the capture enzyme-linked immunosorbent assay. The tIgE level ≤100 kU/L represented negative while >100 kU/L positive. Serum sIgE was assessed by means of the Phadiatop test using the fluoroimmunoassay. The Phadiatop class 0 means negative and class ≥1 positive. Results Serum level of tIgE among healthy adults was 1.14-1 703.70(median 37.18)kU/L, and it was significantly higher in males than in females(P=0.001). The negative and positive rates of serum tIgE were 72.52% and 27.48%, respectively. Serum level of sIgE(Phadiatop)among healthy adults was 0.01-59.50(median 0.05)kU/L, which had no significant significance between the male and the female(P=0.154). The negative and positive rates of Phadiatop were 82.09% and 17.91%, respectively. There were no statistically significant differences in serum tIgE and sIgE levels among different age groups(P=0.119 and P=0.225, respectively). The Spearman rank correlation coefficient between serum tIgE and sIgE levels was 0.683 with statistical significance(positive correlation, P<0.001). There were 368 subjects(94.85%)with negative Phadiatop and 20 subjects(5.15%)with positive Phadiatop in the serum tIgE negative subjects(n=388), while 75 山东大学耳鼻喉眼学报30卷4期 -袁源,等.健康成人血清总IgE和变应原特异性IgE检测及意义 \=-subjects(51.02%)with positive Phadiatop and 72 subjects(48.98 %)with negative Phadiatop in the serum tIgE positive subjects(n=147). Conclusion More than one fourth subjects among healthy adults have a serum tIgE level higher than 100 kU/L, while less than one fifth subjects have a sensitization to inhaled allergens. There is an obvious correlation between the serum levels of tIgE and sIgE. The serum tIgE level below 100 kU/L may have a clinical value to exclude allergen sensitization; however, the sensitized status may not be confirmed when the tIgE level is higher than 100 kU/L, and case history and clinical manifestations also should be considered.
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    Epidemiological investigation of allergic rhinitis in the Qingdao area
    GAO Rong-li1, DING Jian2, ZANG Yan-wei3, YAN Shu1, LIU Ting-ting1, LIU Zan-gang4, GONG Xiang-gui5, ZHOU Xiao-bin6, LI Na1, ZHANG Nian-kai1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (2): 55-60.  
    Abstract1162)      PDF(pc) (1096KB)(2268)       Save

    Objective   To investigate the morbidity of allergic rhinitis(AR) in the Qingdao area and its correlative factors. Methods   A questionnaire survey on AR was performed in the Qingdao area. We applied over two-stage sampling and cluster sampling methods to the mental health of permanent residents, excluding hypertension, diabetes mellitus and rheumatic disease, aged from 5-70 years in the Qingdao area including seven district and five cities. Our investigation had three stages: questionnaire survey, screening of suspected AR patients according to the results of the questionnaire, and suspects of AR.Diagnosis criteria of AR were the guide of AR in diagnosis and treatment in 2009. Results   2052 questionnaires were available. The effective rate was 85.5%.The prevalence rate of AR in residents aged from 5-70 was 12.08% in Qingdao City. The difference of prevalence between females 11.3% and males 12.7% was statistically insignificant(χ2=0.918, P>0.05). The difference of prevalence between city 15% and village 8% was statistically significant(χ2=23.86, P<0.05). According to the classification criteria of ARIA in 2001, 95 residents suffered from intermittent AR, while 153 suffered from persistent AR. The most common allergens of AR were dermatophagoides farinae, house dust mite and shrimp. Conclusion   The prevalence rate of AR in residents is 12.08%. The most common allergens of AR are dermatophagoides farinae, house dust mite and shrimp. The prevalence rate of seasonal allergic rhinitis is less than sustainable, in the village less than in the city.

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    FANG Xiao-ming
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1686)            Save
    To explore the effect of nasal endoscopy for pharyngeal bursitis. Method: Twelve cases of pharyngeal bursitis and eight cases of nasopharyngeal cyst were treated by nasal endoscopy, and 0.9% sodium chloride solution was given for nasal irrigation twice daily. Results: Twelve cases had complete response, six had partial response, and two had no response. The white scar fell off in 2 to 3 weeks. Conclusion: Nasal endoscopy is effective for pharyngeal bursitis.
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    XUE Wei-guo,SUN Jie,JIN Zheng,SHI Wen-bin,XIN Lu,LIN Guo-Jing,LI Jia-yun
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract3294)            Save
    To observe the efficacy and safety of the levofloxacin ear drop in the treatment of otitis media. Method: A randomized, doubleblind, multicenter, ofloxacin ear drop controlled trial was performed. Results: The data of 120 patients were analyzed, and 60 patients were in the group of levofloxacin ear drop and the other 60 in the group of ofloxacin ear drop. Efficacy assessment based on symptom score reducing index showed that the efficacy rate of levofloxacin ear drop was 96.67% and that of the ofloxacin ear drop was 85.00%; the eradication rate of pathogens in the group of levofloxacin ear drop was 96.15% and in the group of ofloxacin ear drop was 95.83%. No significant difference was showed between two groups (both P<0.05). Conclusions: Levofloxacin ear drop is effective and safe in treating otitis media. The efficacy of levofloxacin ear drop is similar to that of ofloxacin ear drop.
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    WANG Li,LU Yong-hui
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract2237)            Save
    To investigate the expression of telomerase activity and human telomerase reverse transcriptase(hTERT) in the nasal polyp tissues and their significance. Method: The expression of hTERT of 40 cases of nasal polyp tissues and 10 cases of normal inferior turbinate tissues was detected by immunohistochemical staining (PV9000 twostep kit). Results: The expression of telomerase in normal inferior turbinate tissues and nasal polyp tissues was 0 and 82.5%, respectively, and the difference was significant. The expression of telomerase had no significant correlation to the tumor grade, but had close correlation to the recurrence. Conclusion: The expression of telomerase is closely related with nasal polyp progression. It could be postulated that telomerase activity could be related with the tendency of polyp to recur.
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    Multipoint hoop to treat internal jugular phlebectasia in children
    LIU Hong-zhen1, LI Ai-wu1, ZHANG Qiang-ye1, ZHANG Fan2, ZHANG Wen-tong1, CUI Xin-hai1, WANG Ke-lai1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (3): 54-56.  
    Abstract1402)      PDF(pc) (1130KB)(2213)       Save

    Objective   To evaluate the efficacy and method of multipoint hoop treatment the internal jugular phlebectasia (IJP) in children. Methods   A retrospective analysis was performed in 15 cases of internal jugular vein phlebectasia patients from August 2005 to October 2010. Surgical intervention confirmed the jugular veins involved 1 case on the left side,12 cases on the right side and 2 cases bilateral. According to the length of the vein, there were 4 to 6 silk threads to go around the vein and each line was about 1 cm apart. Before the ligation, a 1 centimeter silicon tube bracket was placed around the internal jugular vein to keep it open and prevent it from over-dilatation. Results   All of the children were discharged with healing, and were followed up for 10 months to 5 years without recurrence. Conclusion   Multipoint hoop of phlebectasia might be a simple and comfortable procedure for jugular vein phlebectasia. It can maintain the normal flow inside the vessel, especially in bilateral cases.

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    Modified nasal septum modification
    ZHAO Shen-lin,DUAN Li-hua,SONG Dao-liang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1834)      PDF(pc) (206KB)(2210)       Save
    Objective: To evaluate the clinical outcome of modified nasal septum modification for nasal septum deviation. Methods: One hundred and twentysix patients with nasal septum deviation were treated in our hospital. In the operation, the original structure was saved, the deviated nasal septum was modified by resection or fracture, and the hypertrophic inferior turbinate was moved outside by fracture. Results: Nasal septum deviation was successfully corrected with satisfactory ventilation in both sides of the nasal cavity; no perforation or flop of nasal septum occurred in any case. Conclusion: The modified nasal septum modification is safe for teenagers and is an effective method with the advantage of easy manipulation.
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    WANG Hai-ying,CI Jun,FANG Ying,SHEN Guo-qin,GUAN Ye
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1875)            Save
    To explore the effect of nedocromil sodium on allergic rhinitis. Methods: Toluene 2,4 diisocyanate(TDI) was used to sensitize white rabbits as allergic rhinitis models, and nedocromil sodium was used to treat the disease. The changes in nasal mucosa were studied by pathological methods. Results: Symptoms of allergic rhinitis were remarkably relieved after nedocromil sodium treatment. Hematoxylin and eosin staining demonstrated that no edema was found in the nasal mucosa, and small vessels were normal after nedocromil sodium application; whereas edema, vasodilation and inflammatory cell infiltration were discovered in the control group. Conclusion: Nedocromil sodium has salutary effect on alleviating the symptom of nasal congestion, rhinorrhea and sneezing, and on reducing the sensory neuron sensitivity of the mucosa.
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    Perforation of the tympanic membrane in 256 cases
    WU Liu-qing,LIU Hong-qi,TANG Xiang-rong,LIANG Zhi-cheng
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1955)      PDF(pc) (261KB)(2164)       Save
    Objective: To explore the clinical features of perforation of the tympanic membrane and to discuss factors relating to patient condition. Method: The clinical data of 265 cases in hospital from 1996 to 2006 were retrospectively analyzed. Results: Indirect damages were more than direct damages and they were mainly located in the intense position in 239 cases. 246 cases had conductive deafness and 28 had complications of vertigo, facial paralysis of concussion of the brain. After treatment, 244 cases were cured and others had permanent deafness and other symptoms. Conclusion: Each kind of flesh wound may cause not only perforation of the tympanic membrane, but also damage to the middle ear, the internal ear and even the brain. The degree, promptness and comprehensive treatment, condition of ear trouble and the whole body are all closely related to restoration and prognosis.
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    Correlation between skill and relapse in endoscopic sinus surgery
    LIANG Hong-min,LI Yong-li,GUO Qing-bao
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1768)      PDF(pc) (222KB)(2148)       Save
    Objective: To study the correlation between skill and relapse in endoscopic sinus surgery. Method: Relapse induced by improper operative procedures from 2001 to 2005 in our hospital was retrospectively analyzed. Result: Factors of relapse were as follows: the exalted deviation of nasal septum was not remedied; the focus between the egger nasi and the frontal recess was not completely operated on; the ethmoid sinus was not completely opened; the middle turbinate was improperly operated on; the uncinate process was hung over; the ostium maxillary was narrow; polyp in the maxillary sinus was not completely removed; the nasal mucosa stuck together; hypertrophy of the inferior turbinate was not operated on. Conclusion: Great knowledge of anatomy and operative skill and proper treatment of the easily recurrent focus are important to avoid relapse.
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    SHANG Guan han-jing,LI Zhi-chun
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1646)            Save
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    PAN Xin-liang,LEI Da-peng,XU Feng-lei,ZHANG Li-qiang,LUAN Xin-yong
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract2599)      PDF(pc) (316KB)(2114)       Save
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    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1348)      PDF(pc) (254KB)(2113)       Save
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    CHEN He-Xin, ZENG Shu, ZHANG Zhi-Gang, ZHENG Yi-Qiang, PAN Jiao
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2009, 23 (4): 35-37.  
    Abstract3152)      PDF(pc) (261KB)(2110)       Save
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    Excision of the huge vocal cord polyp under electronic laryngoscopy
    HUANG Yi-deng,XIA Si-wen,HUANG Zi-xi,MA Qiong-fan,HU Xian-hui
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract2560)      PDF(pc) (339KB)(2107)       Save
    Objective: To explore the effect of the excision of the huge vocal cord polyp by an electronic laryngoscope. Method: Ten cases, of which three cases suffered from dyspnes in degree I were subjected to excision of the huge vocal cord polyp with an electronic laryngoscope under local anesthesia. Results: Eight cases were cured by one operation and two cases by two operations. No complications were found. All patients had a normal voice by vocal evaluation and vocal acoustic parameter analysis at post-operative three months. Conclusion: It is feasible to excise the huge vocal cord polyp with an electronic laryngoscope. For it, sufficient surgical skills, local anesthesia, and preparations of tracheotomy are necessary.
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    CHEN Yu-wu,GU Dong-sheng,WANG Tian-sheng,WU Chun-ping
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1930)            Save
    To observe the response of endoscopic surgery(ESS)for chronic sinusitis. Methods: A total of 468 patients with chronic nasal sinusitis: 106 of Ⅰtype, 228 ofⅡtype and 134 of Ⅲ type were enrolled in this study. Before operation, all had taken antibiotics, steroid and hormone. After operation, all were followed up and disposed of the crust cyst, small polyp and granulation tissue in time. Results: A total of 350 patients (74.79%)were cured, 96(20.51%)had response, and 22 (4.7%) had no response. The response rate was 95.3%. The main intraoperative complications were hemorrhage and injury of the orbital cavity, and the postoperative complication was adhesion of nasal cavity. Conclusion: ESS has advantages of less injury and good response. Sufficient preparation, operative technique, entire debridement of the focus, correct treatment for middle turbinate and prescriptive following up are the cores for preventing the complications and improving the response.
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    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1558)      PDF(pc) (267KB)(2076)       Save
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    Recombinant human epidermal growth factor gel in the treatment of  nasal septum mucosal erosion and epistaxis
    LI Fu-hong1, FAN Ping2
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2011, 25 (3): 69-70.  
    Abstract6605)      PDF(pc) (286KB)(2070)       Save

    Objective      To observe the efficacy of recombinant human epidermal growth factor gel in the treatment of nasal septum mucosal erosion and epistaxis. Method       Recombinant human epidermal growth factor gel was applied in nasal septum mucosal erosion. Result       The curative rate of 52 cases of nasal septum mucosal erosion was 86.5% in the treatment group and 44.2% in the control group(P<0.01). Conclusion      Recombinant human epidermal growth factor gel in the treatment of nasal septum mucosal erosion and epistaxis obtains a good therapeutic effect.

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    Detection and clinical application of nasal nitric oxide
    Zhiwen CHEN,Lei CHENG
    Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (3): 124-128.   DOI: 10.6040/j.issn.1673-3770.1.2019.026
    Abstract4411)   HTML42)    PDF(pc) (437KB)(2068)       Save

    Nitric oxide (NO) is synthesized from arginine by the enzyme family NO synthases. NO is an endogenous modulator of airway function. NO from the nose can constitute a nasal defensive barrier, and keep the sinuses relatively sterile. The most commonly clinical detection of nasal nitricc oxide (nNO) is to directly collect NO with a nasal plug probe placed in the anterior nostril. nNO has been used for the screening diagnosis of cystic fibrosis and primary ciliary dyskinesia. However, nNO is related to many influences such as the plugged extent of the sinus. Dynamic monitoring nNO before and after treatment, and combination with frictional exhaled nitric oxide (FeNO)examination to early detect eosinophilic inflmmation in the upper and lower airways are more clinically valuable.

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    Tympanic membrane indwelling catheterization under microscope for secretory otitis media following radiotherapy of nasopharyngeal carcinoma
    SHEN Fan,HUANG Ailan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract2503)            Save
    Objective: To evaluate the effect of tympanic membrane indwelling catheter under microscope on secretory otitis media after radiotherapy for nasopharyngeal carcinoma. Method: Twentyseven cases(18 males and 9 females) were treated and followed up. Result: Nine(23.1%) out of 39 ears were cured, and the total efficiency rate was 87.2%(34/39). Conclusion: Tympanic membrane indwelling catheter under microspoce is a favorable way to straighten the eustachian tube function with weak damage.
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    Correlation between prognosis and increase of leucocyte count for the sudden hearing loss
    ZHANG Ming,ZHONG Gang-yi
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract2693)            Save
    Objective: To study the correlation between the prognosis and leucocyte count in sudden hearing loss. Method: A total of 135 cases of sudden hearing loss were retrospectively analyzed. Results: The increase of leucocytes had no correlation with the auditory threshold volume(P>0.05). The curative rate in sudden hearing loss patients with normal leucocyte number was higher than that in patients with increased leucocyte and neutrophil peripheral leucocyte levels. Conclusion: The treatment efficiency for patients with sudden hearing loss with increased leucocyte level is higher than that for patients with normal leucocyte level.
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    Surgical opportunities on facial nerve decompression following intra-temporal facial nerve injury: an experimental study
    LUO Jian-fen,FAN Zhao-min,WANG Hai-bo
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract2312)      PDF(pc) (235KB)(2055)       Save
    To establish animal models of intratemporal facial nerve injury and find the natural developmental features of facial nerve injury. To explore the best time to do facial nerve decompression surgeries and to discover the laws of injured facial nerve recovery after the decompression surgeries. Methods32 200~300g female Wister rats were used, and the tympanic segments of the bone canal of the facial nerves were compressed by minimal forceps. After making the models, rats were randomly divided into 4 equal groups which were given decompression surgery at different times: within 3 weeks group, after 4 weeks group, after 8 weeks group and the control group. In the control group nothing was done. Decompression consisted of removing the crushed bone pieces and incising the epineurial sheath at the abovementioned times. The facial nerve threshold current was measured using the NIMResponse to observe the recovery of the facial nerve at intervals of 4 weeks. ResultsThe complete paralysis rats had no response to the maximal current (3mA) in the first week. No significant difference was found between the control group and the group which had decompression surgery after 8 weeks(P>0.05), but a difference between the other groups and the control group was found(P<0.05). There were significant differences among the three surgery groups(P<0.05). ConclusionsCrushing the facial nerve bone canal by minimal forceps is a reasonable method to make the animal models of intratemporal facial nerve injury. Decompression of the facial nerve performed within two months resulted in a faster recovery of the threshold current. Decompression later than two months had the same recovery speed as no decompression of the facial nerve. During the first two months, the earlier the decompression of the facial nerve was performed, the faster the facial nerve recovered.
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    ZHANG Qiu-gui,HE Hai-yan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract2005)            Save
    To discuss the types of allergens and provide an instruction for prevention and immunotherapy of allergic rhinitis. Method: A total of 856 patients with allergic rhinitis were enrolled, and skin prick test was used in this study. Result: The main allergens were house dust mite and dermatophagoides farinae, and the positivity ratios were 59.5% and 57.9% respectively. Conclusion: Knowing the allergens provides an instruction for prevention and immunotherapy of allergic rhinitis.
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    CHEN Shu-lin,WANG Jing-qing,FAN Yun-ping
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1761)            Save
    To review the diagnosis and treatment for otogenic tetanus. Methods: The diagnosis and treatment experience on a patient suffering from otogenic tenutas was summarized and the associated literatures were reviewed. Results: The patient was diagnosed as having otogenic tetanus precisely when his medical history and physical sign were investigated and examined carefully and cured eventually. Conclusions: If a patient with suppurative otitis media chews inconveniently and opens mouth difficultly following facial muscles dysfunction, the possibility of tetanus should be considered after the oromaxiallofacial region diseases are excluded.
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    CUI Hong,ZHAO Shu-you,ZHANG Qing-quan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract2472)            Save
    Objective: To investigate the expression of oncogene STK15 in laryngeal squamous cell carcinoma(LSCC), and therefore to find out the correlation of STK15 and laryngeal squamous cell carcinoma. Methods: SP immunohistochemical method was used to determine the expression of STK15 in 40 cases of LSCC and 30 cases of vocal cord polyp. Results: STK15 was found in 67.5%(27/40)and 33.3%(10/30)of LCSS and vocal cord polyp, the difference was significant(P<0.05). Expression of STK15 had some relation with the tumor grade and lymphatic metastasis(P<0.05), but not with the pathology grade, primary site of LSCC, patients′gender and age. The degree of STK15 expression was related with the tumor grade(P<0.05). Conclusion: STK15 may play an important role in the pathway of carcinogenesis and progression of LSCC and it may be identified as a new therapeutic target.
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    SHI Li,SHI Bao-yuan,LI Xue-zong,XU Hao-jie
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1897)            Save
    To investigate the method and response of the dacrycystrhinostomy by nasal endoscopy for chronic dacryocystitis and obstruction of lacrimonasal duct. Method: Eight cases(10 sides) of chronic dacryocystitis and 2 cases of occlusion of lacrimonasal duct were dealt with the dacrycystrhinostomy by nasal endoscopy. Results: Followed up for 4 to 9 months, the symptoms were obviously released. Nine cases (11 sides) had been cured and 1 case (1 side) had response. The epithelization was in 3 months. Conclusion: The dacrycystrhinostomy by nasal endoscopy is an effective method with short operation and few injury.
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    Significance of CT imaging for anterior ethmoid sinus variations
    SUN Jian,JU Jian-bao,ZHANG Nian-kai,LI Na,FENG Wei-hua
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract2077)      PDF(pc) (234KB)(2024)       Save
    Objective: To explore anatomical variations of the anterior ethmoid sinus in Chinese people and to provide reference for clinical management. Method: The clinical data of nasal sinus imaging of 263 patients were retrospectively analyzed. Result: There were statistical differences between the adult group and the pediatric group in ethmoid bulla hypertrophy and middle nasal concha etherealization. Conclusion: CT scanning is helpful in detecting anatomical variations interrelated with risk of sinonasal surgery.
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    Therapeutic efficacy of Xuesaitong combined with Gastrodin for sudden deafness
    MA Ya-lin1, REN Ping-zhi2, CHAI Mao-wen1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (2): 44-45.  
    Abstract2189)      PDF(pc) (962KB)(2020)       Save

    Objective   To explore the therapeutic efficacy of Xuesaitong combined with Gastrodin for sudden deafness. Methods   150 patients with sudden deafness were randomly divided into the Xuesaitong group, the Gastrodin group and the combined group, with 50 cases in each group. The combined group was synchronously treated with Xuesaitong and Gastrodin. Their hearing therapeutic efficacies were compared. Results   The total effective rate and recovery rate were 72% and 20% in the Xuesaitong group, 68% and 18% in the Gastrodin group,and 88% and 38% in the combined group. They were significantly higher in the combined group than in the other two groups (all P<0.05). Conclusion   The combined therapy for sudden deafness is obviously better than individual therapy.

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    XIE Zhi-gang,ZHANG Xi-ying
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract2417)            Save
    To investigate the prevention and management of postoperative nasal cavity adhesion in children with sinusitis. Method: The clinical data of 402 children with sinusitis underwent functional endoscopic sinus surgery in our hospital were analyzed. Results: During a followup for more than 6 months, postoperative nasal cavity adhesions were found in 64 patients (82 sides), of which 56 patients (71 sides) were successfully separated by once and 8 patients (11 sides) by many times. The reasons of adhesion were analyzed. Conclusion: The reasons of the nasal cavity adhesions are as follows: rude and improper management on the abnormal anatomy structures in operation, not followed up in time, and using drugs improperly after operation. The prevention and early separation of the postoperative nasal cavity adhesions play important role in improving the curative effect for endoscopic sinus surgery.
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    XIANG Jun,WANG Tian-sheng,GU Dong-sheng,ZENG Dong-qian
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1717)            Save
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    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1711)      PDF(pc) (179KB)(2012)       Save
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    YU Yun-hong,CAI Xiao-lan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1861)            Save
    To discuss the treatment of refractory nasal bleeding under nasal endoscopy. Methods: Nasal endoscopy, electrocoagulation and stuffingup were performed in 60 cases of refractory nasal bleeding under local anesthesia and in 7 cases under general anesthesia. Results: Refractory bleeding mainly happened at the nasal septum of olfactory cleft region and the posterior part. All the patients were cured under nasal endoscopy. Conclusion: Nasal endoscopy is effective in looking up the bleeding points and electrocoagulation is effective in treating the bleeding.
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    Huiwei,FAN Xian-liang,WANG Zhe,ZHANG Hui,JIAN Jing-fen
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract3081)            Save
    Objective: To observe the effect of azelastine hydrochloride and fluticasone propionate nasal spray in treatment of allergic rhinitis. Methods: One hundred and nine patients (mean 35.6 yearslod, ranged from 15 to 76 yearslod) with persistent allergic rhinitis were randomized into mild, moderate or severe groups according to the ARIA. Patients of mild group received azelastine hydrochloride or fluticasone propionate one spray per nostril, two times per day for 30 days. Patients of moderate or severe group received azelastine hydrochloride or fluticasone propionate (with a 30minute interval), or their combination. Results: The effect in mild group was not significantly different between azelastine hydrochloride and fluticasone propionate(86.36% vs 92.00%, P>0.05). In moderate or severe groups, the response rate was 66.67%, 73.33% and 96.88% in azelastine hydrochloride (the first group), fluticasone propionate alone(the second group) and their combination (the third group). There was no significant difference between the first and the second groups(P>0.05). The response rate of the third group was significantly higher than that of the first and the second groups(both P<0.05). There was no significant difference between the total response rate of azelastine hydrochloride and of fluticasone propionate (83.78% vs 90.00%, P>0.05). Conclusion: Azelastine hydrochloride and fluticasone propionate can be used for the firstline pharmacological treatment of allergic rhinitis, and their combination can be used to treat moderate or
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    Therapeutic effects of tympanostomy tube emplacement in the treatments of  20 cases of otitis media with effusion
    LV Mei, XU Er-dong, DU Cui-ping, YAO Yi-wen
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2010, 24 (4): 21-22.  
    Abstract1575)      PDF(pc) (318KB)(2000)       Save

    Objective    To investigate the effectiveness of grommet insertion in the treatments of secretory otitis media. Methods     20 cases of secretory otitis media were chosen and hospitalized from the outpatients who had undertaken 2-3 months of conservative treatments, including medications, puncture of tympanum, or cavum tympani injection. All the cases received grommet insertion. Further, local drug perfusion to the cavum tympani was adminstered regularly. The grommets were kept for about 13 months. Results     The post-operative follow-up times were 6-12 months. The total effective rate was 100% and healing rate was 75%(15/20). The hearing levels of all the cases got improved while the average increase was 20-30 dBHL by pure tone test. Acoustic immitance test showed A type in 15 cases and As type in the other 5. All the tympanic membranes healed naturally without complications, i.e. perforation, shrinkage, or otitis media. Conclusions    Grommet insertion is the primary method to treat refractory secretory otitis media, and the local drugs perfusion is crucial. At the same time, the complications, such as exfoliation of tube, infection, or disunion of tympanium, should be prevented.

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    Animal model of obstructive sleep apnea syndrome in rats
    LIU Zhonglu, WANG Yan, LI Yanzhong
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract2120)      PDF(pc) (365KB)(1994)       Save
    To build up a steady and credible animal model of obstructive sleep apnea syndrome(OSAS). MethodsSodium Hyaluronate was injected into the palatoglossal arch, palatopharyngeal arch and root of the tongue of eight Wistar rats. An electroencephalogram, electromyogram and oronasal airflow were recorded by PSG before and 4 weeks after injection when rats were under light anesthesia, which was expected to be similar to the sleep state. ResultsWhen the animals were under light anesthesia, the electroencephalogram and electromyogram were similar to the sleep state. All animals showed apnea with unusual movements of the thorax and the abdomen before and 4 weeks after injections. Differences between apnea index(AI) and the longest apnea before and after injection of Sodium Hyaluronate was obvious(P<0.05). ConclusionAn animal model of OSAS in rats established by injection of Sodium Hyaluronate was steady, credible and similar to OSAS of human beings. It can be used to study the pathogenesis, pathological and physiological changes, and complication of OSAS.
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    Trachobronchial foreign bodies in adult patients: a retrospective analysis
    LIU He,ZHANG Li-qiang,HE Hai-xian,SUN Rui-jie,XU Hao-jie,WANG Xue-hai,CHEN Cheng-fang,ZHANG Hai-yan,LI Xue-zhong
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract2242)      PDF(pc) (262KB)(1992)       Save
    Objective: To investigate the clinical characteristics and experiences of trachobronchial foreign bodies in adult patients. Methods: The clinical data of 30 cases admitted between October 1996 and May 2006 were retrospectively analyzed. The foreign bodies were varied and mainly were dentures and plants. Results: In one case the foreign body was taken out by direct laryngoscopy, three cases were subjected to emergency tracheotomies, four cases were subjected to rigid bronchoscopies and tracheotomies and the other 22 cases were subjected to rigid bronchoscopies. Conclusion: Trachobronchial foreign bodies are able to be successfully taken out based on their kinds and positions.
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    Measurements of corneal thickness in the clinic
    YANG Xue-qiu1, ZHAO Jing-jing1, ZHUANG Wen-juan2
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (2): 80-82.  
    Abstract2798)      PDF(pc) (1007KB)(1991)       Save

    The corneal thickness parameter is one of the major examination data of the anterior segment. It is used in the diagnosis of ophthalmological diseases, and it is very important in pre-operative assessment for excimer laser refractive surgery. With the development from contact to non-contact measurements, the corneal thickness measurement becomes more and more accurate and secure. In this review, we summarized the recent advances of different corneal thickness measurements in the clinic.

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    GUO Zhi-yong,ZHANG Wen-hua,ZHANG Yu-geng,LIN Peng
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract2370)            Save
    To explore the differences of polysomnography parameters of obstructive sleep apnea hypopnea syndrome (OSAHS) between children and adults. Methods: The sleep of 37 pediatric OSAHS and 35 adult OSAHS patients was monitored. Several parameters, including the apnea index(AI), hypopnea index(HI), apnea hypopnea index(AHI), the lowest oxygen saturation(LSaO2) and the longest apnea time were counted, and the percent of stages of NREM and REM, including the microarousal index was calculated. Results: Many parameters, such as AI, HI, AHI, LSaO2 and the longest apnea time were significantly different between the two groups. The sleep structure of pediatric OSAHS was similar with that of normal children, but different from that of the adult group. Conclusion: The difference of PSG parameters is significant between pediatric OSAHS and adult OSAHS. The standard of adult PSG does not fit for child PSG.
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    A contrast of the therapeutic effects of Nasonex and Rhinocort in the treatment of allergic rhinitis
    XIE Xiao-shuai,LI Liang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract6558)      PDF(pc) (254KB)(1987)       Save
    To investigate the therapeutic effects of Nasonex Nasal Spray(momestasone furoate) and Rhinocort Nasal Spray(budesonide) on allergic rhinitis(AR). Methods160 patients with AR were randomly divided into two groups: the Nasonex group (n=80) were treated with Nasonex once daily (total 200μg) and the Rhinocort group (n=80) were treated with Rhinocort once daily (total 256μg) for 4 weeks. Clinical effects and adverse drug reactions were observed. ResultsThere were statistical differences between the pre-and post-treatment groups (both P<0.05). The total effective rate was 97.5% in the Nasonex group and 92.5% in the Rhinocort group, however, there was no statistical difference between the two groups (P>0.05). No severe adverse drug reaction was found in either group. ConclusionsBoth medicines have good therapeutic effects on allergic rhinitis. Either one can be used for allergic rhinitis alone and achieve ideal therapeutic efficacies.
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