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    Prognostic significance of COX-2,PCNA and p53 in nasopharyngeal carcinoma
    MIAO Bei-ping,LU Yong-tian,XU An-ting
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1226)      PDF(pc) (357KB)(1534)       Save
    Objective: To ascertain the possible roles of COX-2,PCNA and p53 in the tumorigenesis and development of nasopharyngeal carcinoma, and to evalulate their impact on the prognosis of nasopharyngeal carcinoma. Methods: Immunohistochemical assay was used to determine COX-2, PCNA and p53 in all specimens, including 60 cases of nasopharyngeal carcinoma and 30 cases of normal nasopharynx. Results: (1) The overall positive expression rate of COX-2, PCNA and p53 in nasopharyngeal carcinoma was 90%, 75% and 68% respectively, higher than that in the normal nasopharynx. (2) Intensity of expression of COX-2, PCNA and p53 in nasopharyngeal carcinoma was related to tumor stage, tumor differentiation and lymph node metastasis (P<0.05). (3) Expressions of COX-2, PCNA and p53 were correlated with each other in nasopharyngeal carcinoma. (4) Positive COX-2 and PCNA were associated with a lower 5-year survival and they were significant prognostic variables for recurrence(P<0.05). Conclusion: COX-2, PCNA and p53 may play vital roles in the tumorigenesis and development of the cancer via different methods. Unfavorable prognosis was associated with expression of COX-2 and PCNA while not with p53. Immunohistochemical assessment of COX-2 and PCNA might be a useful molecular marker for predicting prognosis in nasopharyngeal cancer.
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    Diagnosis and treatment of tracheobronchial foreign bodies in 180 cases
    CHEN Jing1, WEI Xu-dong2
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    DOI: 10.6040/j.issn.1673-3770.0.2014.017
    Effects of nasal cavity ventilational function by septoplasty with and without partial inferior turbinatomy
    ZHANG Jia-xiong, ZOU Wen-tao, CAI Xiao-jing, QIAN Bei
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (6): 38-39.  
    Abstract682)      PDF(pc) (1062KB)(1182)       Save

    Objective To study effects of nasal cavity ventilational function by septoplasty with and without partial inferior turbinatomy. Methods 109 patients with nasal septum deviation with or without rhinitis-rhinosinusitis were operated from January 2010 to December 2011. 48 patients were operated with septoplasty without partial inferior turbinatomy from January 2010 to December 2010 (group A), while other 61 patients were operated by septoplasty with partial inferior turbinatomy from January 2011 to December 2011 (group B). Results All 109 patients who accepted endoscopic-assisted correction of the nasal septum deviation with or without partial inferior turbinatomy succeeded in the operations without any severe complications. Nasal airflow was flowing more freely in the group B than in the group A, and visual analogue scale of group A was superior to that of group A. Conclusion Septoplasty with partial inferior turbinatomy is better than septoplasty without partial inferior turbinatomy in improving nasal cavity ventilational function.

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    Complications and treatment of UPPP
    ZHANG Hua, ZHANG Qing-quan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (1): 12-14.  
    Abstract758)      PDF(pc) (983KB)(1302)       Save
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    Correlation between cataract phacoemulsification with intraocular lens implantation and age-related macular degeneration
    ZHANG Ai-hui1, ZHU Ling1, ZHANG Jin-zhi1, ZHANG Wei2
    J Otolaryngol Ophthalmol Shandong Univ    2013, 27 (5): 77-83.   DOI: 10.6040/j.issn.1673-3770.0.2013.033
    Abstract427)      PDF(pc) (964KB)(502)       Save

    Objective      To explore the ratio of age-related macular degeneration(AMD) after cataract phacoemulsification with intraocular lens(IOL)implantation, and analyze the influencial factors of postoperative visual acuity and operational effects on AMD. Methods      300 eyes of cataract phacoemulsification combined with IOL implantation from January 2009 to February 2012 in our hospital were retrospectively analyzed. The uncorrected visual acuity, anterior and posterior segment were checked on 1 day, 1 week, 1 month and 3 months postoperatively and the best corrected visual acuity (BCVA) was examined when necessary. BCVA of all patients were examined 3 months after the operation. The visual acuity, complications and fundus check were recorded. Fundus fluorescein angiography (FFA) was performed when patients were diagnosed or suspected as AMD. Indocyanine green angiography (ICGA) and/or optical coherence tomography (OCT) should be examined if needed. The association studies were performed with SPSS 13.0. Results       1. On day 1 postoperative, there were 45 eyes (15.00%) with BCVA < 0.3 and 255 eyes (85.00%) with BCVA ≥ 0.3. 3 months operative, there were 18 eyes (6.00%) with BCVA < 0.3 and 282 eyes (94.00%) with BCVA ≥ 0.3. 2. After the operation, there were 215 eyes with normal fundus, 56 eyes with AMD, 13 eyes with diabetic retinopathy, 7 eyes with high myopia retinopathy; 3 eyes with retinal vein occlusion; 2 eyes with retinal pigment degeneration, 2 eyes with optic atrophy, 1 eye with macular hole and 1 eye with epiretinal membrane of macular. 3. After cataract surgery, AMD was common in early and intermediate stage but rarely in advanced stage. However, the postoperative visual acuity was better than the preoperative. 4. Before cataract surgery, there were 11 eyes which were diagnosed with cataract and AMD. Except 1 eye developed from early AMD to intermediate stage, the rest did not change obviously after the operation.  The difference was not significant (χ2=0.234, P=0.890). Conclusion       AMD is the main fundus disease which affects later vision restoration after cataract phacoemulsification and IOL implantation, followed by DR and high myopia retinopathy. The ratio of AMD is 18.67%, which can be commonly noted in early and intermediate stage after cataract surgery. Cataract operation shows no significant effect on the development of AMD but improves the visual acuity.

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