Abstract:

Objective   To analyze the clinical significance of allergic factors  in patients suffering from chronic sinusitis with or without nasal polyps. Methods   A cohort of 165 patients suffering from chronic sinusitis was randomly selected in this study, in which 98 belonged to CRSwNP, while the other 67  belonged to CRSsNP. All patients were subjected to skin prick test(SPT), and the positive allergens and their distribution features were compared within the CRS groups with 53 patients complaining of allergic rhinitis symptoms. Also, the infiltrating degrees of eosinophil cells in nasal polyp specimens from CRSwNP were analyzed for allergic history, SPT results and past operation history. Results   There was no statistical significance between CRSwNP and CRSsNP for the rate of positive allergen, whereas,  there existed a significant difference between the CRS and AR′s. On the other hand, the differences of the distribution feature in these three were not significant. The higher the degree of eosinophil infiltration in the local polyps, the higher the positive rate of SPT and the allergic factor history, but with no relationship to patients′ past operation history. Conclusion   Allergicfactors have great impacts on both CRSsNP and CRSwNP. It is necessary  to test their allergic conditions in patients with CRSsNP and CRSwNP, which is helpful for early evaluation, therapy and prognosis of these patients.

Key words: Chronic rhinosinusitis；  Nasal polyps；  Allergic factor；  Prognosis