J Otolaryngol Ophthalmol Shandong Univ ›› 2013, Vol. 27 ›› Issue (6): 16-21.doi: 10.6040/j.issn.1673-3770.1.2013.299

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Benefits and risks of I-131 therapy in patients with differentiated thyroid cancer

ZHAO Guo-wei, HE Qing-qing, ZHUANG Da-yong, ZHENG Lu-ming, FAN Zi-yi, ZHU Jian, YU Fang, ZHOU Peng, HOU Lei, JIANG Hui-ping   

  1. Department of Thyroid and Breast, Jinan Military General Hospital, Jinan 250031, China
  • Received:2013-10-10 Published:2013-12-16

Abstract:

The benefits of131I remnant ablation include: ① facilitating the interpretation of subsequent serum thyroglobulin levels; ② increasing the sensitivity of detection of locoregional and/or metastatic disease on subsequent follow-up radioactive iodine whole-body scans; ③ maximizing the therapeutic effect of subsequent treatments, and ④ allowing a postablation scan to help identify additional sites of disease that were not identified on the preablation scan or when a preablation scan was not performed. The potential benefits of 131I adjuvant treatment include decreasing recurrence and disease-specific mortality for unknown microscopic, locoregional, and/or distant metastatic disease. The potential benefits of 131I treatment of known locoregional and/or distant metastases are ① decreasing recurrence, and ② decreasing disease-specific mortality and/or palliation. The more significant risks and side effects involve organ systems including eye/nasolacrimal, salivary, pulmonary, gastrointestinal, hematopoietic, and gonads as well as secondary primary malignancies. Although there are never-ending controversies regarding 131I therapy in differentiated thyroid cancer, the benefits and risks are becoming better understood. This in turn helps the treating physician and patient in making decisions regarding therapy.

Key words: Differentiated thyroid cancer, Complications, 131I ablation

CLC Number: 

  • R736.1
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