JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2015, Vol. 29 ›› Issue (3): 39-42.doi: 10.6040/j.issn.1673-3770.0.2015.067

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Clinical efficacy of Bidouyan oral liquid in combination with low-dose clarithromycin tablets for chronic sinusitis

LIU Qian, RUAN Yijin, ZHU Huaiwen, SHI Xiongzhou, CAI Zhuo   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, Zhongshan Hospital of Guangdong Medical College, Zhongshan 528415, Guangdong, China
  • Received:2015-02-01 Revised:2015-05-08 Published:2015-06-16

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Abstract: Objective To explore the clinical effect of Bidouyan oral liquid in combination with low-dose clarithromycin tablets in treatment of chronic sinusitis. Methods Eighty-six patients with chronic sinusitis were randomly divided into the treatment group and the control group, forty-three patients in each group. The patients in both groups received clarithromycin tablets 250 mg per time, once a day, besides patients in the treatment group were given Bidouyan oral liquid 10ml for per time, three times a day. Changes of visual analogue score, nasal endoscopy Lund Kennedy score and paranasal sinus CT scanning score were measured before and after a three- month treatment. Results The VAS core, nasal endoscopy and sinus CT scan score of the treatment group were significantly decreased (t=21.23, 30.23, 25.81, P<0.05), and compared with the control group, the difference was statistically significant (t=10.21, 12.79, 9.58, P<0.05). The total effect rates in the treatment group and the control group were 83.72% and 65.12% (U=752.5, P<0.05). Both groups had no obvious adverse reaction. Conclusion Bidouyan oral liquid in combination with low-dose clarithromycin tablets treatment has significant clinical efficacy on chronic sinusitis.

Key words: Sinusitis, chronic, Oral liquid, Clarithromycin

CLC Number: 

  • R765.4+1
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[1] FENG Xin-rong,ZHANG Hong-xia,LIU Ying,SUN Zhao-tong . Assessment of long-term low-dose clarithromycin for chronic sinusitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 38-40 .
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