阻塞性睡眠呼吸暂停综合征慢性低氧与非酒精性脂肪肝的相关性

doi:10.6040/j.issn.1673-3770.0.2015.175

Abstract

Abstract: Objective To investigate the correlation between chronic hypoxia caused by obstructive sleep apnea hypopnea syndrome (OSAHS) and nonalcoholic fatty liver disease (NAFLD). Methods A total of 927 OSAHS patients were divided into simple sleep apnea group (n=63), mild hypoxemia OSAHS group (n=202), moderate hypoxemia OSAHS group (n=332), and severe hypoxemia OSAHS group (n=330), according to the lowest oxygen saturation (LSaO₂) and apnea hyponea index (AHI) collected by polysomnography (PSG). The low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides (TG), total cholesterol (TC) level of all patients were examined, and abdominal ultrasound was conducted. Results ① As anoxia aggravated, the detection rate of OSAHS with NAFLD increased. In severe hypoxemia, the detection rate of OSAHS with NAFLD was higher than that of simple sleep apnea, mild and moderate hypoxemia. ② There were significant differences in BMI, TC, TG, HDL-C, LDL-C in OSAHS patients with NAFLD and without NAFLD (all P<0.05). ③ The BMI, TC, TG, LDL-C, moderate and severe hypoxemia were independent risk factors for OSAHS with NAFLD. Conclusion OSAHS patients with long-term chronic hypoxia are susceptible to NAFLD. To improve patients' long-term anoxic state, weight loss and control of triglyceride levels may effectively prevent the occurrence of NAFLD.

Key words: Sleep apnea hypopnea syndrome, obstructive, Non-alcoholic fatty liver disease, Hyoxemia, Triglyceride, Obesity

CLC Number:

R766.7

MEI Xubin, ZOU Xinbo, ZHAO Limin, ZOU Huizhong, CHEN Zhengang, LIU Wenjun. Correlation between chronic hypoxia caused by obstructive sleep apnea syndrome and nonalcoholic fatty liver disease[J].JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(5): 11-13.

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Correlation between chronic hypoxia caused by obstructive sleep apnea syndrome and nonalcoholic fatty liver disease

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