Abstract: Objective To observe the effects of multimodal analgesia with parecoxib sodium and tramadol on postoperative analgesia, incidence of adverse reactions and inflammatory factors in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS)after uvulopalatopharyngoplasty(UPPP). Methods A total of 60 OSAHS cases were randomly divided the into the test group(T group, n=30, receiving parecoxib sodium and tramadol)and control group(C group, n=30, receiving tramadol only). Both groups received patient-controlled intravenous analgesia with tramadol after UPPP. Data of visual analog scale(VAS)for pain in 48 h postoperatively, rescue analgesic use and adverse reactions were collected. Inflammatory factors including TNF-α, IL-6, IL-10 and ICAM-1 were measured with ELISA. Results Lower VAS scores, less use of rescue analgesic and fewer adverse reactions were showed in T group(P<0.01, P<0.05, P<0.05). Decreased levels of TNF-α and IL-6 were found in T group(P<0.01, P<0.05), while there were no statistically significant differences in the levels of IL-10 and ICAM-1 between the two groups. Conclusion Multimodal analgesia with parecoxib sodium and tramadol can prolong the postoperative analgesia, demand less use of rescue analgesic, and cause fewer adverse reactions, which may play a positive role in the inhibition of inflammatory reaction after UPPP.

Key words: Uvulopalatopharyngoplasty, Parecoxib sodium, Tramadol, Inflammatory factors, Multimodal analgesia