Abstract: Objective To explore and discuss the treatment strategy of benign osteogenic tumors with involvement of nasal skull base area, including osteoma, ossifying fibroma and fibrous dysplasia. Methods 140 patients with benign fibro-osseous lesion of naso-siunses were treated surgically, including 116 cases of osteoma, 14 cases of ossifying fibroma and 10 cases of fibrous dysplasia. Surgical methods include simple nasal endoscopic surgery in 95 cases, image navigation assisted nasal endoscopic surgery in 24 cases, nasal endoscopy combined with external nasal approach in 21 cases. Results No serious complications occurred in all cases who underwent different operations. All osteomas were completely removed. Ossifying fibromas were completely removed in 12 cases, except 2 cases with residual lesions. All cases of fibrous dysplasia were received the palliative surgery, and the facial appearances of the patients were recovered and the compressive symptoms of the surrounding tissues were relieved. The follow-up period ranged from 6 to 36 months. No recurrence was found in patients with osteoma; recurrence occurred in 2 cases ossifying fibroma; the symptoms of fibrous dysplasia get different degree of ease, except 1 patient with visual loss remained unchanged. Conclusion Osteoma, ossifying fibroma and fibrous dysplasia are common benign osteogenic lesions of paranasal sinuses. High resolution CT and(or)MRI are important means for early diagnosis. Endoscopic sinus surgery under the guidance of image navigation or combined with external nasal approach is an effective method for the treatment of these diseases. The choice of operation opportunity and surgical methods should be based on the type of lesion, the patients symptoms, the location and scope of the tumor.

Key words: Therapy, computer-assisted, operation, Fibrous dysplasia, Osteoma, Fibro-osseous tumor, Endoscopic sinus surgery, Ossifying fibroma