Abstract: Objective To explore the ocular hypotensive efficacy of Ex-PRESS glaucoma filtration device implantation in patients with glaucoma and its effect on corneal endothelial cell counts. Methods Sixty-two patients with glaucoma treated at our hospital were divided into the control and research groups. The control group comprised 31 patients(33 eyes)treated with compound trabeculectomy, and the research group comprised 31 patients(35 eyes)treated with Ex-PRESS glaucoma filtration device implantation. Results The total surgical success rate was significantly higher in the research group(88.57%)than in the control group(66.67%; P<0.05). Although the vision of patients in both groups improved significantly at 6 months after the operations(P<0.05), improvement was significantly better in the research group(85.71%)than in the control group(60.61%; P<0.05). The intraocular pressure in both groups was significantly lower after operation than before(P<0.05). However, at 1, 3, and 6 months after operation, the intraocular pressure was significantly lower in the research group than in the control group(P<0.05). The corneal endothelial cell counts in both groups were significantly lower at 1, 3, and 6 months after operation than before(P<0.05). No significant intergroup difference in corneal endothelial cell counts was observed at 1, 3, and 6 months after operation(P>0.05). The complication rate was significantly lower in the research group(17.14%)than in the control group(45.45%; P<0.05). Conclusion In patients with glaucoma, the long-term effects of Ex-PRESS glaucoma filtration device implantation on intraocular pressure were superior to those of trabeculectomy, and the effects of both treatments on corneal endothelial cell counts were comparable.

Key words: Ex-PRESS glaucoma filtration deviceimplantation, Trabeculectomy, Glaucoma, Corneal endothelial cell