Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (4): 10-17.doi: 10.6040/j.issn.1673-3770.1.2019.027

• Invited Review • Previous Articles     Next Articles

Significance of induction chemotherapy in late treatment of locally advanced hypo-pharyngeal cancer

Xiaobo CUI*()   

  1. Department of Otolaryngology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia, China
  • Received:2019-05-07 Online:2019-07-16 Published:2019-07-22
  • Contact: Xiaobo CUI E-mail:cxbgh@sina.com

Abstract:

Early symptoms of hypopharyngeal cancer were not obvious because tumorigenesis in concealed areas. Almost 2/3 of hypopharyngeal cancer were diagnosed as middle and advanced stage, when first seeing a doctor.It is a malignant tumor with poor prognosis in head and neck tumors. In recent years, in order to improve the prognosis, we advocate a comprehensive treatment model combining surgery, radiotherapy and chemotherapy. Value of induction chemotherapy has been noticed in organ preservation and metastasis rate reduction. But in the actual clinical work, the role of induction chemotherapy (IC) in the treatment of locally advanced hypopharyngeal cancer has been disputed because every physicians′ understanding of the advantages and disadvantages of the guidelines and treatment methods and differences in clinical experience. How to choose the most reasonable one based on the patients′general and local conditions from many different treatment methods is an issue that has been explored in during treatment of hypopharyngeal cancer. This paper points out the author′s individual experience the induction chemotherapy in treatment of locally advanced hypopharyngeal cancer by literature review and case analyses.

Key words: Hypopharyngeal neoplasms, Induction chemotherapy, Organ preservation, Individualized treatment

CLC Number: 

  • R767

Fig.1

Typical cases"

Fig.2

Typical cases"

Fig.3

Typical cases"

Fig.4

Typical cases"

Fig.5

Typical cases"

Fig.6

Typical cases"

1 屠规益, 胡郁化. 下咽癌的外科治疗[J]. 中华耳鼻咽喉科杂志, 1986, 12: 85- 87.
2 张宗敏, 唐平章, 徐震纲, 等. 下咽鳞癌不同治疗方案的临床分析[J]. 中华肿瘤杂志, 2005, 27 (1): 48- 51.
doi: 10.3760/j.issn:0253-3766.2005.01.013
ZHANG Zongmin , TANG Pingzhang , XU Zhengang , et al. Long-term results of different treatment modalities in 464 hypopharyngeal squamous-cell carcinoma patients[J]. Chin J Oncol, 2005, 27 (1): 48- 51.
doi: 10.3760/j.issn:0253-3766.2005.01.013
3 Ma J , Liu Y , Huang XL , et al. Induction chemotherapy decreases the rate of distant metastasis in patients with head and neck squamous cell carcinoma but does not improve survival or locoregional control: A meta-analysis[J]. Oral Oncol, 2012, 48 (11): 1076- 1084.
doi: 10.1016/j.oraloncology.2012.06.014
4 Bauman J , Langer C , Quon H , et al. Induction chemotherapy with cetuximab, carboplatin and paclitaxel for the treatment of locally advanced squamous cell carcinoma of the head and neck[J]. Experimental and Therapeutic Medicine, 2013, 5 (4): 1247- 1253.
doi: 10.3892/etm.2013.948
5 Janoray G , Pointreau Y , Garaud P , et al. Long-term results of a multicenter randomized phase Ⅲ trial of induction chemotherapy with cisplatin, 5-fluorouracil, ±docetaxel for larynx preservation[J]. J Natl Cancer Inst, 2016, 108 (4): djv368.
doi: 10.1093/jnci/djv368
6 廖恺, 毕卓菲, 何艳, 等. TPF或PF方案诱导化疗治疗局部晚期头颈鳞癌的Meta分析[J]. 循证医学, 2012, 12 (5): 278- 285.
doi: 10.3969/j.issn.1671-5144.2012.05.007
LIAO Kai , BI Zhuofei , HE Yan , et al. Induction chemotherapy with cisplatin and fluorouracil alone or with taxanes for locally advanced squamous-cell cancer of the head and neck: A meta-analysis[J]. J Evid-Based Med, 2012, 12 (5): 278- 285.
doi: 10.3969/j.issn.1671-5144.2012.05.007
7 Pointreau Y , Garaud P , Chapet S , et al. Randomized trial of induction chemotherapy with cisplatin and 5-fluorouracil with or without docetaxel for larynx preservation[J]. Journal of the National Cancer Institute, 2009, 101 (7): 498- 506.
doi: 10.1021/jf011209e
8 Fabregas JC , Loaiza-Bonilla A , Talebi TN , et al. Concurrent chemoradiotherapy versus induction chemotherapy followed by chemoradiotherapy (sequential approach) in the management of head and neck cancer[J]. Expert Rev Anticancer Ther, 2013, 13 (9): 1065- 1072.
doi: 10.1586/14737140.2013.829639
9 Voichita BA , Joshua P , Yang HS , et al. Current management of locally advanced head and neck cancer : the combination of chemotherapy with locoregional treatments[J]. Seminars in Oncology, 2014, 41 (6): 798- 806.
doi: 10.1053/j.seminoncol.2014.09.018
10 Cohen EE , Karrison TG , Kocherginsky M , et al. Phase Ⅲ randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer[J]. J Clin Oncol, 2014, 32 (25): 2735- 2743.
doi: 10.1200/JCO.2013.54.6309
11 Lefebvre JL . Laryngeal preservation in head and neck cancer: multidisciplinary approach[J]. Lancet Oncol, 2006, 7 (9): 747- 755.
doi: 10.1016/S1470-2045(06)70860-9
12 Tada Y , Maruya SI , Saotome T , et al. Phase Ⅰ/Ⅱ study of docetaxel, cisplatin and S-1 in locally advanced, recurrent and metastatic head and neck squamous cell carcinoma[J]. Oncol Lett, 2012, 4 (5): 898- 904.
doi: 10.3892/ol.2012.846
13 鲁光平, 潘骥群, 刘志标. DCF方案诱导化疗后手术治疗喉癌及下咽癌T2-3病变疗效分析[J]. 临床耳鼻咽喉头颈外科杂志, 2015, 29 (7): 585- 588.
doi: 10.13201/j.issn.1001-1781.2015.07.002
LU Guangping , PAN Jiqun , LIU Zhibiao . Efficacy analysis of sequential surgery after the DCF scheme induction chemotherapy in T2-3 laryngeal carcinoma and hypopharyngeal carcinoma[J]. J Clin Otorhinolaryngol Head Neck Surg, 2015, 29 (7): 585- 588.
doi: 10.13201/j.issn.1001-1781.2015.07.002
14 Denaro N , Russi EG , Lefebvre JL , et al. A systematic review of current and emerging approaches in the field of larynx preservation[J]. Radiother Oncol, 2014, 110 (1): 16- 24.
doi: 10.1016/j.radonc.2013.08.016
[1] DAI Yacuo, LI Jing, WAN Baoluo, ZANG Yanzi, HUANG Yingming. Individualized treatment of pharyngeal and laryngeal cavernous hemangioma:a report of two cases. [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 110-112.
[2] FU Yugui, WANG Hailan, SUN Dechong, YANG Peizhen, CHEN Yanlin, CHEN Zhipeng. Total laryngectomy with partial preservation of the cricoid cartilage ring. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 73-75.
[3] QIAN Xiaofei, ZHANG Suqin, CHEN Jianliang. Laryngeal function-sparing surgery for pyriform sinus cancer: a retrospective analysis of 14 cases. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(4): 35-37.
[4] YAO Lei1, ZHANG Zhonghua1, MA Chao2, LEI Dapeng1, PAN Xinliang1
. Expression of Slit2 and its correlation with microvessel density in hypopharyngeal squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2009, 23(1): 10-14 .
[5] DONG Pin,LI Xiao-yan,TU Li-qiang,MENG Qing-hong,WANG Sang,XIE Jin,JIANG Yan . Reconstruction for advanced hypopharyngeal carcinoma and laryngeal recurrent carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2007, 21(5): 385-387 .
[6] LIU Da-yu,PAN Xin-liang,LEI Da-peng,ZHANG Li-qiang,LUAN Xin-yong . Surgical treatment for medial wall pyriform sinus cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2007, 21(1): 8-11 .
[7] YUAN Ying,PAN Xin-liang,LUAN Xin-yong,XU Feng-lei,LIU Da-yu,LEI Da-peng . Surgical treatment for posterior hypopharyngeal wall carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2007, 21(1): 15-19 .
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 84 -87 .
[2] NIU Shanli,CHAI Maowen,LI Zhenxiu . Endoscopic rhinoplasty of inferior turbinate in 60 patients with chronic hypertrophic rhinitis[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 16 -18 .
[3] MENG Qing-guo,LU Yong-tian,FAN Xian-liang .

Association of killer cell immunoglobulin-like receptor gene polymorphisms with nasopharyngeal carcinoma

[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 196 -199 .
[4] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 199 -199 .
[5] WAN Li-jia,LU Hai-tao,JIANG Yi-dao,LIU Hui,LI Qin,SHE La-zhi . Effect of H-uvulopalatopharyngoplasty on obstructive sleep apnea
hypopnea syndrome
[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 204 -205 .
[6] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 222 -224 .
[7] JI Xiao-bin,DENG Jia-de,ZANG Lin-quan,WANG Lei,XIE Jun . Blood histamine in guinea pigs with allergic rhinitis[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 228 -230 .
[8] XIANG Deng,LU Yong-tian,SUN Huan-ji . Endoscopic repair for cerebrospinal fluid rhinorrhea in 19 cases and a literature review [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 234 -236 .
[9] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 253 -257 .
[10]
YIN Guo-hua,ZHONG Xiao . Long-term effect of laser reduction on lingua adenoids
[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 280 -282 .