Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (2): 34-38.doi: 10.6040/j.issn.1673-3770.1.2020.096

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A study of low-temperature plasma ablation for the treatment of benign thyroid nodules under ultrasound guidance

LI Jianzhong1, ZHOU Yongrui2, LI Huiying1, LI Miaobian1, SUN Yidi1, QIU Qianhui3   

  1. 1. Department of Otorhinolaryngology, Jiangmen Wuyi Hospital of Traditional Chinese Medicine, Jiangmen 529000, Guangdong, China;
    2. Department of Ultrasound, Jiangmen Wuyi Hospital of Traditional Chinese Medicine, Jiangmen 529000, Guangdong, China;
    3. Department of Otorhinolaryngology, Guangdong Provincial People's Hospital, Guanzhou 510055, Guangdong, China
  • Published:2021-04-20

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Abstract: Objective To evaluate the clinical value of low temperature plasma ablation in the treatment of benign thyroid nodules under ultrasound-guidance. Methods 36 patients with benign thyroid nodules receiving the treatment of low temperature plasma ablation under ultrasound-guidance were randomly selected from October 2019 to October 2020. To study the volume(V), volume reduction rate(VRR)of thyroid nodule before operation and 1 month, 3 months and 6 months after operation, and serum free triiodothyronine(FT3), free thyroxine(FT4), thyrotropin(TSH)before operation and 1 month after operation, to evaluate the effectiveness and safety of low temperature plasma ablation in benign thyroid nodules under ultrasound-guidance. Results After related treatment, the volume of benign thyroid nodules gradually decreased and the volume reduction rate increased, the difference was statistically significant(F(1.311,45.887)=378.369;P<0.001); There was no statistic difference in TSH between the patients before the operation and the 1 month after treatment(P=0.123). Comparison of FT3 and FT4 before and 1 month after operation, FT3 and FT4 in 1 month after operation were slightly higher

Key words: Ultrasound-guidance, Low temperature plasma ablation, Benign thyroid nodules, Serum free triiodothyronine, Serum free thyroxine, Thyrotropin

CLC Number: 

  • R581
[1] Shan ZY, Chen LL, Lian XL, et al. Iodine status and prevalence of thyroid disorders after introduction of mandatory universal salt iodization for 16 years in China: a cross-sectional study in 10 cities[J]. Thyroid, 2016, 26(8): 1125-1130. doi:10.1089/thy.2015.0613.
[2] 房居高. 强化手术技能和规范诊疗是提高甲状腺癌疗效的根本[J]. 山东大学耳鼻喉眼学报, 2016, 30(2): 1-4. doi:10.6040/j.issn.1673-3770.1.2016.01. FANG Jugao. Operation skill and standard diagnosis and treatment are the basics of improving the curative effect of thyroid carcinoma[J]. J Otolaryngol Ophthalmol Shandong Univ, 2016, 30(2): 1-4. doi:10.6040/j.issn.1673-3770.1.2016.01.
[3] 李晓曦. 2016年美国临床内分泌医师协会《甲状腺结节诊断和治疗临床实践医学指南》解读[J]. 中国实用外科杂志, 2017,37(2): 157-161. doi:10.19538/j.cjps.issn1005-2208.2017.02.14. LI Xiaoxi. The interpretation of medical guidelines for clinical practice for the diagnosis and management of thyroid nodules-2016 UPDATE[J]. Chin J Pract Surg, 2017, 37(2): 157-161. doi:10.19538/j.cjps.issn1005-2208.2017.02.14.
[4] 娄雪峰, 吴凤林, 纪莉, 等. 射频消融高风险甲状腺结节避免喉返神经损伤的方法探讨[J]. 中国超声医学杂志, 2014,30(07), 30: 577-580. LOU Xuefeng, WU Fenglin, JI Li, et al. Research on methods of avoiding recurrent laryngeal nerve injury during radiofrequency ablation of thyroid nodules in high risk location[J]. Chin J Ultrasound Med, 2014, 30(7): 577-580.
[5] 章建全, 盛建国, 刁宗平, 等. 液体隔离法在颈部结节性病变经皮热消融治疗中的应用[J]. 第二军医大学学报, 2014,35(10): 1045-1052. ZHANG Jianquan, SHENG Jianguo, DIAO Zongping, et al. Application of hydro-dissection technique in percutaneous thermal ablation of neck nodular lesions[J]. Acad J Second Mil Med Univ, 2014, 35(10): 1045-1052.
[6] 陈婷婷, 帕提玛, 赵迎忠, 等. 超声引导下经皮微波消融治疗甲状腺良性结节的临床价值[J]. 临床超声医学杂志, 2016, 18(8): 532-534. doi:10.16245/j.cnki.issn1008-6978.2016.08.010. CHEN Tingting, PA Tima, ZHAO Yingzhong, et al. Ultrasound guided percutaneous microwave ablation in the treatment of benign thyroid nodules[J]. J Clin Ultrasound Med, 2016, 18(8): 532-534. doi:10.16245/j.cnki.issn1008-6978.2016.08.010.
[7] 田鹏, 王延珍, 杜文燕, 等. 超声引导下微波消融治疗甲状腺良性腺瘤的体积缩小率与消融时间的相关性研究[J]. 中国中西医结合影像学杂志, 2019,17(2): 167-169,173. TIAN Peng, WANG Yanzhen, DU Wenyan, et al. Study on the correlation between the volume reduction rate and the ablation time of ultrasound-guided benign thyroid adenomas[J]. Chin Imaging J Integr Tradit West Med, 2019, 17(2): 167-169,173.
[8] 潘新良. 加强甲状腺结节及恶性肿瘤的规范治疗[J]. 山东大学耳鼻喉眼学报, 2020,34(3): 1-12. doi:10.6040/j.issn.1673-3770.1.2020.037. PAN Xinliang. Improving the standard treatments for thyroid nodules and malignant tumors[J]. J Otolaryngol Ophthalmol Shandong Univ, 2020, 34(3): 1-12. doi:10.6040/j.issn.1673-3770.1.2020.037.
[9] 钱林学. 超声引导下射频及微波消融在甲状腺结节治疗中的应用[J]. 中华医学超声杂志(电子版), 2013,10(11): 1-4.
[10] 苗刚勇, 肖旭平, 谭志强. 低温等离子射频技术在婴幼儿甲状舌管囊肿手术中的应用[J]. 山东大学耳鼻喉眼学报, 2015, 29(6): 52-55. doi:10.6040/j.issn.1673-3770.0.2015.289. MIAO Gangyong, XIAO Xuping, TAN Zhiqiang. Application of low temperature radiofrequency volumetric tissue reduction in infant lingual thyroglossal duct cyst[J]. J Otolaryngol Ophthalmol Shandong Univ, 2015,29(6): 52-55. doi:10.6040/j.issn.1673-3770.0.2015.289.
[11] 李潜, 董永玲, 王雁, 等. 超声引导下射频消融治疗甲状腺良性实性结节效果观察[J]. 中华实用诊断与治疗杂志, 2015, 29(8): 815-816. doi:10.13507/j.issn.1674-3474.2015.08.033. LI Qian, DONG Yongling, WANG Yan, et al. Therapeutic effect of ultrasound-guided radiofrequency ablation on benign solid thyroid nodule[J]. J Chin Pract Diagn Ther, 2015, 29(8): 815-816. doi:10.13507/j.issn.1674-3474.2015.08.033.
[12] 王勇飞, 殷德涛, 马润声, 等. 超声引导下射频消融治疗甲状腺良性结节153例疗效分析[J]. 西安交通大学学报(医学版), 2018, 39(1): 9-12. WANG Yongfei, YIN Detao, MA Runsheng, et al. Treatment efficacy of 153 cases of thyroid benign nodules by ultrasound-guided radiofrequency ablation[J]. J Xi'an Jiaotong Univ Med Sci, 2018, 39(1): 9-12.
[13] 王淑荣, 岳雯雯, 张永林, 等. 超声引导下经皮微波消融治疗甲状腺良性结节的疗效观察[J]. 中华超声影像学杂志, 2015(8): 675-679. WANG Shurong, YUE Wenwen, ZHANG Yonglin, et al. Application of ultrasound-guided percutaneous microwave ablation treatment in patients with benign thyroid nodules[J]. Chinese Journal of Ultrasonography, 2015(8): 675-679.
[14] 叶亮, 孙科, 张超, 等. 甲状腺良性结节热消融后残余结节的研究进展[J]. 中国普外基础与临床杂志, 2019, 26(11): 1361-1366. YE Liang, SUN Ke, ZHANG Chao, et al. Research progress of residual nodules after thermal ablation for benign thyroid nodules[J]. Chin J Bases Clin Gen Surg, 2019, 26(11): 1361-1366.
[15] Valcavi R, Riganti F, Bertani A, et al. Percutaneous laser ablation of cold benign thyroid nodules: a 3-year follow-up study in 122 patients[J]. Thyroid, 2010, 20(11): 1253-1261. doi:10.1089/thy.2010.0189.
[16] 刘娟, 吴凤林, 隋洋, 等. 超声引导下经皮激光消融甲状腺良性实性结节[J]. 南方医科大学学报, 2013,33(10): 1529-1532. doi:10.12122/j.issn.1673-4254.2013.10.026. LIU Juan, WU Fenglin, SUI Yang, et al. Ultrasound- guided percutaneous laser ablation for benign solid thyroid nodule: a pilot study[J]. J South Med Univ, 2013,33(10): 1529-1532. doi:10.12122/j.issn.1673-4254.2013.10.026.
[17] 胡晓静, 余厉阳, 顾运茹, 等. 低温等离子消融致细胞及蛋白裂解机制的实验研究[J]. 中国生物医学工程学报, 2020,39(2): 252-256. doi:10.3969/j.issn.0258-8021.2020.02.15. HU Xiaojing, YU Liyang, GU Yunru, et al. Experimental study on the mechanism of cell and protein cleavage during low temperature plasma ablation[J]. Chin J Biomed Eng, 2020,39(2): 252-256. doi:10.3969/j.issn.0258-8021.2020.02.15.
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