Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (1): 120-124.doi: 10.6040/j.issn.1673-3770.0.2021.366

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Primary large B-cell lymphoma of tonsil in children: a case report and document review

ZHAO Xinghe, FAN Mingyue, DOU Xunwu, JIA Guangbiao   

  1. Department of Children's Hospital of Soochow University, Soochow 215003, Jiangsu, China
  • Published:2022-02-22

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Abstract: Objective To investigate the clinical manifestations, diagnostic strategy, pathological examination and immunohistochemical characteristics of primary large B-cell lymphoma of tonsil in children. Methods The clinical data of a child with primary large B-cell lymphoma of the tonsil admitted to our hospital in January 2021 were reviewed. Relevant domestic literatures on primary malignant B-cell lymphoma of the tonsil in children were searched through CNKI and Wanfang database, and the data were analyzed. Results Children Male, April 10, may because of the pharynx ministry unwell, January admission with the soft palate of ulcer, perfect relevant inspection after admission, the pharynx and neck lesions after biopsy and pathology report shows:(neck lump, tonsil)combined with HE and immunohistochemical markers, consider B cell lymphoma that tends to diffuse large B cell lymphoma. Then transferred to the tumor surgery department of our hospital for 5 times of CCCG-BNHL-2015 chemotherapy regimen.After that, the stability was recovered, and the left neck lymph node enlargement and tonsil enlargement were examined again. The left tonsil biopsy suggested chronic hypertrophic tonsillitis..Follow-up observation is currently under way.Reviewing this case and 10 cases of primary malignant B lymphoma of tonsil reported in the literature with detailed clinical data, most of them were characterized by pharyngeal discomfort, tonsil enlargement, sleep snoring and other symptoms, with or without cervical lymph node enlargement.Pathological examination indicated malignant B-cell lymphoma with immunohistochemical expression of CD20, MUM1, Bcl-6 and Bcl-2, and chemotherapy was performed after surgery. with followed up for a long time. Conclusion Primary large B-cell lymphoma of the tonsil in children is rare. Preoperative symptoms are mostly tonsil enlargement and cervical lymph node enlargement, accompanied by nasopharyngeal discomfort and other symptoms. It is easy to be misdiagnosed, and a definite diagnosis should be made by pathological examination and immunohistochemistry. Early diagnosis and multidisciplinary comprehensive treatment can improve the clinical treatment rate.

Key words: Children, Tonsil, Primary large B-cell lymphoma, Clinical treatment

CLC Number: 

  • R766
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