Abstract: Objective To summarize and analyze the clinical features, diagnostic methods, and treatment of low-grade non-intestinal-type adenocarcinoma(non-ITAC)within the nasal cavity. Methods The clinical data of a patient with low-grade non-intestinal-type adenocarcinoma within the nasal cavity was retrospectively analyzed with further review of relevant literature to summarize its clinical manifestations, diagnosis, treatment and prognosis. Results The patients underwent follow-up for 9 months, and had no symptoms such as nasal obstruction, purulent and/or bloody nasal discharge. Granulation tissue could be seen at and below the ostium of the sphenoid sinus. Based on the clinical data of this patient, we reviewed previous reports in the Chinese and English databases on low-grade non-ITAC within the nasal cavity, totaling 18 cases. The data showed CK7 was positive(94.4%), CK20 was negative(61.1%), CDX-2 was negative(61.1%), Ki-67 proliferation index was 1%~15%, treatment using only surgery(77.8%), postoperative adjuvant radiotherapy(16.6%), and surgery after radiotherapy(5.6%).The patients were closely followed-up for 9 months to 6 years, with an average follow-up time of 35.8 months. Ten of them had no recurrence. Conclusion The clinical and imaging features of non-ITAC of the nasal cavity and paranasal sinuses are important for diagnosis, and the pathological immunology is helpful for grading, treatment and prognosis.

Key words: Nasal cavity and paranasal sinus, Non-intestinal type adenocarcinoma, Low-grade, CK7, Ki-67