Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2025, Vol. 39 ›› Issue (2): 116-120.doi: 10.6040/j.issn.1673-3770.0.2023.392

• Original Article • Previous Articles     Next Articles

Trousseau's syndrome in tonsil carcinoma complicated by multiple acute cerebral infarctions: a case report and literature review

PENG Xin, WEI Xianfeng, LIANG Yibo, QIAO Jie, WANG Wei, LIN Peng, LI Li   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, Tianjin First Central Hospital/ Institute of Otolaryngology of Tianjin/ Key Laboratory of Auditory Speech and Balance Medicine/Key Medical Discipline of Tianjin (Otolaryngology)/ Quality Control Centre of Otolaryngology, Tianjin 300192, China
  • Published:2025-03-26

PDF (PC)

20

Abstract: Patients with malignant tumors face a higher risk of developing thrombosis compared to those without tumors. The relationship between the occurrence of thrombus and tumor is called Trousseau's syndrome(TS). This thrombotic event is unpredictable, potentially occurring before or concurrently with the detection of an underlying malignancy. TS is relatively rare, presenting clinically as multiple lesions causing infarction in multiple vascular territories, and its prognosis is poor. Herein, we report a case of TS and review the literature. We aimed to assist head and neck surgeons in recognizing and improving the prognosis of this condition.

Key words: Trousseau's syndrome, Thrombosis, Tonsil carcinoma, Cerebral infarction

CLC Number: 

  • R543.6
[1] 林玉凤, 拱忠影, 汪志云. 以反复多灶性脑梗死起病的卵巢癌致特鲁索综合征一例[J]. 中华老年心脑血管病杂志, 2021, 23(11): 1214-1215. doi:10.3969/j.issn.1009-0126.2021.11.024 LIN Yufeng, GONG Zhongying, WANG Zhiyun. A case of Trousseau’s syndrome caused by ovarian cancer with repeated multifocal cerebral infarction[J]. Chinese Journal of Geriatric Heart Brain and Vessel Diseases, 2021, 23(11): 1214-1215. doi:10.3969/j.issn.1009-0126.2021.11.024
[2] Lecumberri R, Páramo JA, Rocha E. Anticoagulant treatment and survival in cancer patients. The evidence from clinical studies[J]. Haematologica, 2005, 90(9): 1258-1266
[3] De Stefano V. Arterial thrombosis and cancer: the neglected side of the coin of Trousseau syndrome[J]. Haematologica, 2018, 103(9): 1419-1421. doi: 10.3324/haematol.2018.197814
[4] Sack GH Jr, Levin J, Bell WR. Trousseau's syndrome and other manifestations of chronic disseminated coagulopathy in patients with neoplasms: clinical, pathophysiologic, and therapeutic features[J]. Medicine, 1977, 56(1): 1-37
[5] Yoon DW, Shin DW, Cho JH, et al. Increased risk of coronary heart disease and stroke in lung cancer survivors: a Korean nationwide study of 20, 458 patients[J]. Lung Cancer, 2019, 136: 115-121. doi:10.1016/j.lungcan.2019.08.025
[6] Bao L, Zhang SY, Gong XY, et al. Trousseau syndrome related cerebral infarction: clinical manifestations, laboratory findings and radiological features[J]. J Stroke Cerebrovasc Dis, 2020, 29(9): 104891. doi:10.1016/j.jstrokecerebrovasdis.2020.104891
[7] 卫亚楠, 陈曦. 局部晚期头颈部鳞状细胞癌的化疗及靶向进展[J]. 山东大学耳鼻喉眼学报, 2021, 35(3): 118-124. doi: 10.6040/j.issn.1673-3770.0.2020.276 WEI Yanan, CHEN Xi. Progress in chemotherapy and targeted drug therapy for locally advanced head and neck squamous cell carcinoma[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(3): 118-124. doi: 10.6040/j.issn.1673-3770.0.2020.276
[8] Repetto O, De Re V. Coagulation and fibrinolysis in gastric cancer[J]. Ann N Y Acad Sci, 2017, 1404(1): 27-48. doi:10.1111/nyas.13454
[9] Ito S, Kikuchi K, Ueda A, et al. Changes in serial D-dimer levels predict the prognoses of trousseau’s syndrome patients[J]. Front Neurol, 2018, 9: 528. doi:10.3389/fneur.2018.00528
[10] Nouh AM, Staff I, Finelli PF. Three Territory Sign: an MRI marker of malignancy-related ischemic stroke(Trousseau syndrome)[J]. Neurol Clin Pract, 2019, 9(2): 124-128. doi:10.1212/CPJ.0000000000000603
[11] 陆中华, 韩一平, 周瑛, 等. 恶性肿瘤相关性脑梗死研究进展[J]. 中国脑血管病杂志, 2018, 15(4): 206-211. doi:10.3969/j.issn.1672-5921.2018.04.008 LU Zhonghua, HAN Yiping, ZHOU Ying, et al. Research progress of malignant tumor-related cerebral infarction[J]. Chinese Journal of Cerebrovascular Diseases, 2018, 15(4): 206-211. doi:10.3969/j.issn.1672-5921.2018.04.008
[12] 刘国红, 卞光利, 彭爱琴, 等. 表现为急性双侧前后循环脑梗死的Trousseau综合征的MRI特征[J]. 临床放射学杂志, 2019, 38(3): 406-409. doi:10.13437/j.cnki.jcr.2019.03.009 LIU Guohong, BIAN Guangli, PENG Aiqin, et al. The MRI features of trousseau's syndrome in which the symptom was acute cerebral infarct with bilateral anterior-posterior circulation involved[J]. Journal of Clinical Radiology, 2019, 38(3): 406-409. doi:10.13437/j.cnki.jcr.2019.03.009
[13] 李苗, 党晓凤, 薛艺东, 等. 特鲁索综合征一例报道并文献复习[J]. 实用心脑肺血管病杂志, 2021, 29(2): 133-136. doi:10.12114/j.issn.1008-5971.2021.00.017 LI Miao, DANG Xiaofeng, XUE Yidong, et al. Trousseau syndrome: a case report and literature review[J]. Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease, 2021, 29(2): 133-136. doi:10.12114/j.issn.1008-5971.2021.00.017
[14] 黎芳丽, 姜卉, 蒋锡丽. 特鲁索综合征相关性急性脑梗死的MRI表现[J]. 现代医用影像学, 2020, 29(5): 843-846. LI Fangli, JIANG Hui, JIANG Xili. MRI manifestations of acute cerebral infarction associated with trousseau syndrome[J]. Modern Medical Imagelogy, 2020, 29(5): 843-846.
[15] 徐泽勤, 郭连瑞. 颈动脉狭窄诊疗进展[J]. 山东大学耳鼻喉眼学报, 2020, 34(4): 11-15. doi: 10.6040/j.issn.1673-3770.1.2020.054 XU Zeqin, GUO Lianrui. Advances in the diagnosis and treatment of carotid artery stenosis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(4): 11-15. doi: 10.6040/j.issn.1673-3770.1.2020.054
[16] Tsushima M, Metoki N, Hagii J, et al. D-dimer and C-reactive protein as potential biomarkers for diagnosis of trousseau's syndrome in patients with cerebral embolism[J]. J Stroke Cerebrovasc Dis, 2020, 29(2): 104534. doi:10.1016/j.jstrokecerebrovasdis.2019.104534
[17] Nakao S, Masuda T, Sakamoto S, et al. Cerebral embolism during edoxaban administration for venous thromboembolism in a patient with lung adenocarcinoma: a case report[J]. Medicine, 2019, 98(12): e14821. doi:10.1097/MD.0000000000014821
[18] Dammacco F, Vacca A, Procaccio P, et al. Cancer-related coagulopathy(Trousseau's syndrome): review of the literature and experience of a single center of internal medicine[J]. Clin Exp Med, 2013, 13(2): 85-97. doi:10.1007/s10238-013-0230-0
[19] Bendas G, Borsig L. Cancer cell adhesion and metastasis: selectins, integrins, and the inhibitory potential of heparins[J]. Int J Cell Biol, 2012, 2012: 676731. doi:10.1155/2012/676731
[20] Ikushima S, Ono R, Fukuda K, et al. Trousseau's syndrome: cancer-associated thrombosis[J]. Jpn J Clin Oncol, 2016, 46(3): 204-208. doi:10.1093/jjco/hyv165
[21] Xavier FD, Hoff PMG, Braghiroli MI, et al. Rivaroxaban: an affordable and effective alternative in cancer-related thrombosis [J]. J Glob Oncol, 2017, 3(1): 15-22. doi:10.1200/JGO.2015.002527
[22] Raskob GE, van Es N, Verhamme P, et al. Edoxaban for the treatment of cancer-associated venous thromboembolism[J]. N Engl J Med, 2018, 378(7): 615-624. doi:10.1056/NEJMoa1711948
[23] Franco-Moreno A, Cabezón-Gutiérrez L, Palka-Kotlowsa M, et al. Evaluation of direct oral anticoagulants for the treatment of cancer-associated thrombosis: an update[J]. J Thromb Thrombolysis, 2019, 47(3): 409-419. doi:10.1007/s11239-018-1783-2
[24] Plantureux L, Mège D, Crescence L, et al. Impacts of cancer on platelet production, activation and education and mechanisms of cancer-associated thrombosis[J]. Cancers, 2018, 10(11): 441. doi:10.3390/cancers10110441
[25] Connolly GC, Phipps RP, Francis CW. Platelets and cancer-associated thrombosis[J]. Semin Oncol, 2014, 41(3): 302-310. doi:10.1053/j.seminoncol.2014.04.009
[26] Mai H, Xia J, Wu YJ, et al. Clinical presentation and imaging characteristics of occult lung cancer associated ischemic stroke[J]. J Clin Neurosci, 2015, 22(2): 296-302. doi:10.1016/j.jocn.2014.05.039
[27] 郭琳佳, 刘文宏. 恶性肿瘤合并急性脑梗死的临床特点及预后分析[J]. 中风与神经疾病杂志, 2019, 36(1): 37-42. doi:10.19845/j.cnki.zfysjjbzz.2019.01.008 GUO Linjia, LIU Wenhong. Clinical and prognosis features of acute ischemic stroke patient with cancer patient[J]. Journal of Apoplexy and Nervous Diseases, 2019, 36(1): 37-42. doi:10.19845/j.cnki.zfysjjbzz.2019.01.008
No related articles found!
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 89 -89 .
[2] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 90 -91 .
[3] LIU Da-yu,PAN Xin-liang,LEI Da-peng,ZHANG Li-qiang,LUAN Xin-yong . Surgical treatment for medial wall pyriform sinus cancer[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2007, 21(1): 8 -11 .
[4] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(2): 188 -188 .
[5] LIU Yan,LIU Xin-yi,WANG Jin-ping,LI Da-jian . Measurement of the posterior tympanum and its clinical significance [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 218 -221 .
[6] ZHAO Min,WANG Shou-sen,ZHEN Ze-nian,CHEN Xian-ming,WANG Mao-xin . Sphenoid sinus and trans-sphenoid surgery under nasal endoscopy and microscopy [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 244 -245 .
[7] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 252 -252 .
[8] LI Guang-hao . Selective low position and horizontal tracheotomy in larynx neoplasm[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(4): 325 -326 .
[9]

YU De-xian,ZHANG Wen-shan,PI Shi-jun,CAO Gui-xia,LI Yong-qiang,MA Qing,HUANG Jian

. Oil gauze of traditional Chinese medicine for nasal packing after functional endoscopic sinus surgery[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(4): 340 -342 .
[10] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(4): 381 -382 .
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd