Abstract: Objective To perform a retrospective descriptive analysis of the clinical features of localized amyloidosis(LA)of the larynx and to search for biochemical indicators that may be associated with pathogenesis. Methods Clinical symptoms and blood biochemical measurement data from case records of patients with pathologically diagnosed laryngeal LA were descriptively analyzed, and risk factors associated with laryngeal LA in men and women were analyzed by binary logistic regression using case-control study methodology. Results 1.General description of the 46 patients with laryngeal LA: 31 males and 15 females, male-to-female ratio of 2.07∶1.00, age at first diagnosis of 46 years old, and main symptom of hoarseness. The site of laryngeal LA lesions, unilateral vocal folds in 18 cases, bilateral vocal folds in 16 cases, and non-vocal area in 12 cases. The duration of hoarseness symptoms before diagnosis was long, with a mean of(86.57±32.52)months. 37 cases of laryngeal LA underwent laryngoscopic CO₂ laser resection, and the remaining 6 were treated with conventional laryngoscopic surgery, and only 1 case recurred 10 years after surgery. The median follow-up period was 10.61 years, and only one case died of cerebral hemorrhage 1.5 years after surgery, and all other patients survived, with a survival rate of 97.8%. 2.Comparative analysis of male and female patients with laryngeal LA: males had higher levels of alanine aminotransferase(ALT), aspartate aminotransaminase(AST), and gamma-glutamyl transpeptidase(GGT)than women, and the difference was statistically significant. In the regression analysis with reciprocal adjusting factors, an association was found between elevated ALT levels and the risk of laryngeal LA in men(OR=1.461,95%CI=1.021-2.090, P=0.038). Conclusion Laryngeal LA, whose main symptom is hoarseness and which lasts for a long time before diagnosis, is more frequent in men than in women, and surgical resection is highly effective,with a survival rate of more than 95% after 10 years of follow-up. The gender comparison suggests that elevated ALT may be associated with the risk of laryngeal LA in men, but multicenter prospective studies with larger samples are needed to confirm this.

Key words: Throat, Localized amyloidosis, Alanine aminotransferase, Aspartate transaminase, Gamma-glutamyl transferase