JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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DNA analysis of the cell cycle in sino-nasal neoplasm

GONG Lei1, SUN Jie1, XUE Zi-chao2, LI Jing-hua3, XUE Wei-guo1   

  1. 1. Department of Otorhinolaryngology & Head and Neck Surgery, Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao 266011, Shandong, China; 2. Department of Clinical Medicine, Grade 2005, Xiangya School of Medicine, Central South University, Changsha 410008, China; 3. Department of Pathology, Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao 266011, Shandong, China
  • Received:2008-04-02 Revised:2008-06-05 Online:2008-06-16 Published:2008-06-16
  • Contact: SUN Jie

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Abstract: To explore the significance of the cell cycle in sino-nasal neoplasm by flow cytometry (FCM). Methods30 cases of paraffin-embedded malignant tumors in nasal cavities or sinuses served as the experimental group and 30 cases of normal mucosa of deflection of the nasal septum as the control group. The DNA index(DI) value and the S-phase fraction(SPF) values were determined by FCM and their correlation was analyzed. ResultsThe DI and SPF values of the experimental group were significantly higher than those of the control group. ConclusionFlow cytometric analysis of DI and SPF plays an important role in diagnosis of sino-nasal neoplasm.

Key words: DNA index, S-phase fraction tumor, Flow cytometry, Sinus neoplasms

CLC Number: 

  • R730.21
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