Abstract:

Objective:To find the therapeutical effect of systemic inflammation in sleep disordered breathing(SDB) children after adnotonsillectomy. Methods:Polysomnography monitoring was performed in 65 snoring children all night and Conners concise questionnaire was applied to assess children′s behavior symptoms The change of serum C-reactive protein levels and improvement in abnormal behavior were compared in obstructive sleep apnea-hypopnea syndrome(OSAHS) childrenand primary snoring children before and 1 year after adnotonsillectomy. Results:The Conner′s concise  symptom questionnaire behavior score and serum C-reactiveprotein content of children with OSAHS were significantly higher than those of primary snoring children and healthy control children; and the two above indicators were also significantly higher in primary snoring children than in healthy control children. After adnotonsillectomy the score in Conners concise symptom questionnaire of OSAHS children was decreased form 14.2±3.8 to 6.7±3.1(P<0.05), and the serum C-reactive protein was decreased from (4.25±1.78)mg/L to(3.23±1.45)mg/L(P<0.05). The score of abnormal behavior in the primary snoring group was decreased from 9.4±4.1 to 5.1±2.8(P<0.05); the serumCreactive protein concentration fell from (2.77±1.80)mg/L to (1.76±0.81)mg/L(P<0.05). Conclusion:OSAHS and primary snoring children are  frequently associated with increases of CRP levels and a lot of behavior disorder problems,and those indicators and symptoms can become reversible after treatment by adnotonsillectomy.

Key words: Sleep disordered breathing; Children; Behavior disorder; C reactive protein; Adenotonsillectomy