JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2009, Vol. 23 ›› Issue (3): 17-20.

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Abnormal expression of PI3Kp85 in nasopharyngeal carcinoma

 HUANG Fang, KANG Rui   

  1. Department of Otorhinolaryngology, Second Hospital of Fujian Medical University, Quanzhou 362000, Fujian, China
  • Received:2009-04-15 Revised:2009-05-14 Online:2009-06-16 Published:2009-06-16

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Abstract:

Objective  To detect expression of PI3Kp85 in nasopharyngeal carcinoma(NPC) and chronic nasopharyngitis and to explore its role in the development of NPC. Methods  An immunohistochemical (streptavidin-perosidase SP) method was used to analyze protein expression of PI3Kp85 in paraffin embedded tissues from 57 cases of nasopharyngeal carcinoma and 20 cases of chronic nasopharyngitis. Average optical density (MOD) of the immunohistochemical Image was determined using ImageProPlus software. Results  The positive rates of PI3Kp85 protein in nasopharyngeal carcinoma tissues and chronic nasopharyngitis tissues were 78.95% and 45.00% (P＜0.05).  Expression of PI3Kp85 had no relation to lymph node metastasis, clinical pathological stage, size of primarily focus and sex and age of patients (P＞0.05). Conclusion   Expression of PI3Kp85 protein  may  relate to the occurrence of nasopharyngeal carcinoma.

Key words: Nasopharyngeal carcinoma; PI3Kp85； Abnormal expression； Immunohistochemistry

CLC Number: 

  • R739.63
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