Abstract: To study the feasibility and effect of substituting the esophagus with the stomach without thoracotomy in the treatment of hypopharynx and thoracic segment esophagus synchronous multiple primary carcinoma. MethodsFive patients with hypopharynx and thoracic segment esophagus synchronous multiple primary carcinoma who had undergone esophageal stripping without thoracotomy and gastropharyngostomy were retrospectively studied. The larynx remained in 3 cases and total laryngectomy was performed on 2 cases. ResultsThe function of deglutition was good in the 5 cases. Pharyngeal fistula occurred in 1 case and was cured by conservation treatment.The laryngeal function preservative rate was 60.0% (3/5) and the decannulation rate was 100% (3/3). Followed up from 1 to 4 years, 1year survival rate was 100% (5/5) and 3year survival rate was 60% (3/5). ConclusionSubstituting the esophagus with the stomach without thoracotomy might improve both local control and survival in the treatment of hypopharynx and thoracic segment esophagus synchronous multiple primary carcinoma.