JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2010, Vol. 24 ›› Issue (3): 15-18.

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Expression and implication of focal adhesion kinase and MMP9 in squamous cell carcinoma of larynx

GAO Shang, LI Dawei, DONG Pin, WANG Guo, SHEN Bin   

  1. Department of Otolaryngo1ogy＆Head and Neck Surgery, First Affiliated Hospital of Shanghai Jiaotong University, Shanghai 200080, China
  • Received:2010-03-30 Revised:2010-05-21 Online:2010-06-16 Published:2010-06-16

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Abstract:

Objective  To investigate the expressions and implications of focal adhesion kinase(FAK)， matrix metalloproteinase(MMP9) in human squamous cell carcinoma of larynx． Methods  SP immunohistochemical technique was used to detect the expressions of FAK， MMP9 in 57 human squamous cell carcinoma of larynx and 10 paracarcinoma． Results  Positive expressions of FAK， MMP9 were found in 66.7％ and 63.2% of laryngeal squamous cell carcinoma， which were significantly higher than those in paracarcinoma (10.0% and 20.0% respectively. P<0.05).The positive expression of FAK correlated with the clinical stage and lymph node metastasis(P<0.05)， but not with patient′s gender， age， tumor location， tumor size or the degree of differentiation. So did  MMP9. Furthermore， the positive expression of FAK correlated significantly with the expression of MMP9(P<0.01)． ConclusionIn   squamous cell carcinoma of larynx， FAK， MMP9 is overexpressed. Moreover,  the correlation between the expression of MMP9 and that of  FAK implies both play important roles in enhancing the metastasis and invasion of squamous cell carcinoma of larynx.

Key words: Squamous cell carcinoma of larynx；  Focal adhesion kinase； Matrix

CLC Number: 

  • R739.65
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