Abstract:

Objective     To measure levels of serum soluble tumor necrosis factor receptors (sTNFR)  and   to explore their clinical significance in the diagnosis and monitoring of laryngeal cancer. Methods     The serum levels of sTNFRⅠand sTNFRⅡ were measured by avidinbiotin complex enzyme-linked immunosorbent assay (ABC-ELISA) in 42 laryngeal cancer patients and 40 healthy adults. Results      The serum levels of sTNFRⅠ in laryngeal cancer patients (1463.34±669.07pg/mL)were significantly higher than in the control group(549.30±293.29pg/mL, P<0.05), but the sTNFRⅡ levels were not  (P> 0.05); There was no significant difference among the levels of sTNFRⅠ and sTNFRⅡ in different types of laryngeal cancer(P> 0.05), while significant differences in the sTNFRⅠ level at the various developing periods of laryngeal cancer were found (P<0.05). The change of sTNFRⅡ levels, in the various periods of laryngeal cancer was of no significant difference (P>0.05). The sTNFRⅠ level of laryngeal cancer patients with lymph node metastasis were much higher than of  patients without lymph node metastasis (P<0.05), however, the difference of sTNFRⅡ levels between patients with and without lymph node metastasis was not significant (P> 0.05).Conclusion      Detection of serum levels of sTNFRⅠ may have practical value in the early diagnosis and  prognosis of laryngeal cancer.

Key words: Soluble tumor necrosis factor receptor; Enzyme-Linked Immunosorbent; laryngeal cancer