JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2011, Vol. 25 ›› Issue (1): 17-19.

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Expression of macrophage migration inhibitory factor  in human carcinomas of the hypopharynx

ZENG Zhi-mei1, LIANG Yong-hui2, YANG Yi-fang2, DOU Xiao-qing2,LUO Bi-qiang2, ZHANG Li-wei2, CHEN Xian-ming2   

  1. 1. Department Of Otolaryngology & Head and Neck Surgery， Fuzhou General Hospital， Clinical Medical College,
    Fujian Medical University， Fuzhou 350025, China;
    2. Department of Otolaryngology & Head and Neck Surgery， Fuzhou General Hospita1 of PLA， Fuzhou 350025,   China
  • Received:2010-09-15 Revised:2010-11-05 Online:2011-02-16 Published:2011-02-16

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Abstract:

Objective    To study expression of macrophage migration inhibitory factor (MIF) in hypopharynx carcinoma，and to explore the relationship between MIF and invasion and metastasis of hypopharynx carcinoma. Methods    Expression of MIF was detected in 22 hypopharynx carcinomas and 10 benign lessions(vocal polyp) by immumohistochemistry. The tumor tissues 、lymph node metastasis  and adjacent normal tissue  were tested. Results     Expression of MIF in the tumors and metastases was higher than the adjacent normal tissue and benign lession(P<0．05)．Expression rates of MIF in tumors with lymph node metastasis was significantly higher than those without (P<0．05)．The difference of MIF expressions between stages I、Ⅱ and llI、IV  was significant（40.00％ vs 94.12%）(P<0．05)． Conclusion    MIF may play an important role in invasion and metastasis of hypopharynx carcinoma.The later stage of disease, the higher expression of MIF is shown in primary tumors and metastasis.

Key words: Hypopharynx carcinoma; Metastasis； Macrophage migration inhibitory factor (MIF)

CLC Number: 

  • R739.65
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