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24 May 2023 Volume 37 Issue 5

  

综述

Advances in the application of optical coherence tomography angiography in the diagnosis and treatment of age-related macular degeneration

ZHANG Xiaohan, LI Yansong, WANG Ping

Journal of Otolaryngology and Ophthalmology of Shandong University. 2023, 37(5):  149-156.  doi:10.6040/j.issn.1673-3770.0.2022.310

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Age-related macular degeneration(AMD)is a group of age-related macular diseases associated with multiple pathogenesis such as oxidation stress, complement dysregulation and polymorphism of age-related maculopathy susceptibility 2 allele. The incidence of AMD has been increasing significantly in recent years. The development of the imaging technology provided the conditions for us to study more about AMD, fundus fluorescein angiography(FFA)has been the gold standard for the diagnosis of AMD, however, as an invasive test, FFA can't show the tomographic structure of the lesion. Optical coherence tomography can show the tomographic structure of the retina, but it can't show blood flow patterns. Optical coherence tomography angiography(OCTA)can show the blood flow and structure in all layers of the retina and choroid under non-invasive conditions, and it has become an indispensable tool in studying the pathogenesis, diagnosis and treatment of AMD, because of its unique advantages in showing the blood flow status and structure of the retinal and choroidal vessels. In this paper, we will provide an updated review of the application of OCTA in the diagnosis and treatment of AMD.