JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (6): 22-23.doi: 10.6040/j.issn.1673-3770.0.2016.178

Previous Articles     Next Articles

Efficacy of sodium bicarbonate and fluconazole in the treatment of fungal otitis externa.

SHEN Li   

  1. Department of Otolaryngology, Liyang Traditional Chinese Medicine Hospital, Liyang 213300, Jiangsu, China
  • Received:2016-04-21 Online:2016-12-16 Published:2016-12-16

PDF (PC)

1772

Abstract: Objective To explore the clinical efficacy of sodium bicarbonate combined with fluconazole in the treatment of fungal otitis externa. Methods Using random parallel control method, 105 patients with fungal otitis externa were divided into three groups: the treatment group(ear bath with sodium bicarbonate plus fluconazole injection); control group 1(ear bath with fluconazole injection); control group 2(ear bath with 2% salicylic acid alcohol), with 35 cases in each group. The treatment lasted for 10 days. The patients were followed up for one year to observe the curative effect. Results The total effective rate of the 3 groups were 91.43%, 85.71%, and 77.14%. The efficacy of the treatment group was better than that of the control groups(P<0.05). Conclusion Sodium bicarbonate combined with fluconazole is better than 2% salicylic acid alcohol or fluconazole alone in the treatment of fungal otitis externa.

Key words: Fluconazole, Salicylic acid, Sodium bicarbonate, Fungal otitis externa

CLC Number: 

  • R763
[1] 尹世芬. 外耳道真菌病三种抗真菌药物治疗的效果观察[J]. 齐齐哈尔医学院学报, 2012, 33(8):1005-1006. YIN Shifen. Observation on clinical application of three kinds of anti-fungis on fungi disease of outer ears[J]. J Qiqihar Med Univ, 2012, 33(8):1005-1006.
[2] Jia X, Liang Q, Chi F, et al. Otomycosis in Shanghai: aetiology, clinical features and therapy[J]. Mycoses, 2012, 55(5):404-409.
[3] 吴小飞. 氟康唑氯化钠注射液外用于外耳道治疗真菌性外耳道炎的可行性及安全性[J]. 社区医学杂志, 2012, 10(22):6-7. WU Xiaofei. Feasibility and safety of external application of fluconazole and sodium chloride injection for fungal otitis externa[J]. J Community Med, 2012, 10(22):6-7.
[4] 舒畅, 吴庆莲, 吴雯. 氟康唑注射液灌洗法治疗真菌性外耳道炎73例[J]. 中国伤残医学, 2011, 19(9):57. SHU Chang, WU Qinglian, WU Wen. Fluconazole injection irrigation treatment for 73 cases of fungal otitis externa[J]. Chin J Traumaz Disability Med, 2011, 19(9):57.
[5] 白素萍. 碱性溶液耳浴加微波照射治疗真菌性外耳道炎的观察与护理[J]. 全科护理, 2010, 8(5):377-378. BAI Suping. Observation and nursing care of patients with external auditory canal otomycosis treated with alkaline solution ear bath and microwave irradiation[J]. Chin General Nursing, 2010, 8(5):377-378.
[1] . Gargle with sodium bicarbonate solution combined with nystatin suspension atomization inhalation in 32 cases of mycotic pharyngitis. [J]. J Otolaryngol Ophthalmol Shandong Univ, 2017, 31(2): 121-122.
[2] ZHU Jiangbin, SUN Xiuqin, NAN Bingwei, HAO Zongsheng. 5% Sodium Bicarbonate Injection and Nystatin Tablets mixture gauze for treating fungal otitis externa mycotica in 156 cases [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(6): 82-83.
[3] HUANG Xiongchao, LIAO Shouben, DONG Shiting, ZHONG Haijian, QIN Yongqian. Efficacy of fluconazole for fungal otitis externa (71 cases report) [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(3): 29-30.
[4] SHUAI Shao-shuai, HE Xia-yi, NING Hong- zhu, LUO You-qiong, LIANG Si-min. Clinical observation of corneal stronmal layer injection in the treatment of fungal keratitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(5): 76-78.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd