Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2026, Vol. 40 ›› Issue (5): 65-72.doi: 10.6040/j.issn.1673-3770.0.2025.024

• Pediatric Otorhinolaryngology Head and Neck Surgery • Previous Articles    

Efficacy of graphene-based heated nasal mask combined with mometasone furoate nasal spray and montelukast in the treatment of pediatric obstructive sleepapnea-hypopnea syndrome

LIU Bin1, ZHAO Huiming1, CHEN Kun1, LI Yafei1, CHEN Zi1, LONG Liangzhen2   

  1. 1. Department of Otorhinolaryngology & Head and Neck Surgery, Shijiazhuang People's Hospital, Shijiazhuang 051130, Hebei, China2. Grahope New Materials Technologies Inc, Shenzhen 518116, Guangdong, China
  • Published:2026-09-07

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Abstract: Objective To investigate the clinical value of graphene-based heated nasal masks combined with mometasone furoate nasalspray and montelukast sodium in the treatment of pediatric obstructive sleep apnea-hypopnea syndrome(OSAHS). Methods A total of 100 pediatric patients with OSAHS due to isolated adenoid hypertrophy were enrolled and randomly assigned to a control group(n=50)and an observation group(n=50). The control group received treatment with mometasone furoate nasal spray and montelukast sodium. The observation group received the same treatment regimen supplemented with graphene-based heated nasal masks. Treatment outcomes, sleep-disordered breathing parameters, serum inflammatory cytokine levels, and sleep-related quality of life indicators were observed and compared between the two groups. Results The overall response rate was higher in the observation group than in the control group, with a statistically significant difference as determined by a T-test(P=0.021). Compared with the control group, patients in the observation group exhibited lower obstructive apnea index(OAI), apnea-hypopnea index(AHI), and oxygen desaturation index(ODI)scores post-treatment, but higher lowest arterial oxygen saturation(LSaO2)levels(P<0.05). Serum Interleukin-6(IL-6), C-reactive protein(CRP), and tumor necrosis factor-alpha(TNF-α)levels showed statistically significant differences(P<0.05). Scores of Pittsburgh sleep quality index(PSQI)and total scores of obstructive sleep apnea-18 survey(OSA-18)were significantly lower(P<0.05), while actual sleep duration was longer(P<0.05). Stratified analysis by obesity level indicated that, following the stratification based on obesity status, there were notable changes in indicators of sleep-disordered breathing, improvements in sleep quality, and reductions in serum inflammatory factor levels before and after treatment. were smaller in obese patients than in those with normal weight. Conclusion The combination of graphene-based heated nasal masks with mometasone furoate nasal spray and montelukast sodium for treating patients with simple adenoid hypertrophy complicated by OSAHS can reduce clinical symptoms and enhance the therapeutic efficacy. However,this approach shows no significant effect in obese pediatric patients with OSAHS.It is recommended to incorporate dietary guidance and weight management into the treatment regimen.

Key words: Obstructive sleep apnea hypopnea syndrome, Children, Graphene, Obesity, Adenoid hypertrophy

CLC Number: 

  • R725.6
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