Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2026, Vol. 40 ›› Issue (5): 18-24.doi: 10.6040/j.issn.1673-3770.0.2025.461

• Pediatric Otorhinolaryngology Head and Neck Surgery • Previous Articles    

Advances in metabolomics for pediatric obstructive sleep apnea-hypopnea syndrome

JIANG Yue1,2, GU Yajun2, WANG Junguo2, QIAN Xiaoyun1,2   

  1. 1. Department of Otorhinolaryngology & Head and Neck Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210029, Jiangsu, China2. Department of Otorhinolaryngology & Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, China
  • Published:2026-09-07

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Abstract: Objective sleep apnea-hypopnea syndrome(OSAHS)is a common disorder in children,characterized by recurrent upper airway obstruction and intermittent hypoxemia. Itcan lead to long-term adverse consequences including impaired neurocognitive function and cardiovascular development. Polysomnography(PSG)is currently the gold standard for diagnosis; however, it is operationally cumbersome and poorly tolerated by pediatric patients. Several studies have applied metabolomics to identify characteristic metabolic alterations in children with OSAHS, explore potential early-warning biomarkers, and analyze the metabolic profiles of associated complications,with the aim of better guiding clinical diagnosis and treatment. This review aims to summarize recent advances in metabolomics research related to pediatric OSAHS.

Key words: Obstructive sleep apnea-hypopnea syndrome, Metabolomics, Biomarkers, Diagnosis, Children

CLC Number: 

  • R766.4
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