JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (1): 1-4.doi: 10.6040/j.issn.1673-3770.0.2015.487

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Study on single-nucleotide polymorphisms of microRNA and susceptibility to allergic rhinitis in Han population of southern China.

DENG Yuqin, YANG Yaqi, TAO Zezhang, KONG Yonggang, XU Yu, CHEN Shiming, XIAO Bokui.   

  1. Department of Otolaryngology &Head and Neck Surgery, Peoples Hospital of Wuhan University, Wuhan 430060, Hubei, China
  • Received:2015-11-17 Online:2016-02-16 Published:2016-02-16

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Abstract: Objective To explore the new molecular markers of susceptibility to allergic rhinitis by analyzing the relationship between single nucleotide polymorphisms(SNP)of microRNA(miRNA)and susceptibility to allergic rhinitis. Methods A total of 216 patients with allergic rhinitis were collected as the allergic rhinitis group, and 84 healthy people at the same term were collected as the control group. The peripheral venous blood was drawn in both groups, and genome DNA was extracted. The SNP of pre-miR-146a was detected using pyrosequencing technique to analyze its gene polymorphic site rs2910164 genotype and allele frequency. Results Both CC genotype frequency and allele C frequency of pre-miR-146a(rs2910164)in the allergic rhinitis group were dramatically higher than in the control group(P=0.031). Through analysis on the relative risk of genotype frequency, it was found that the risk of patients with CC genotype who suffered from allergic rhinitis increased(OR=1.799, 95% CI: 1.042-3.107), and the risk of those with allele C who suffered from allergic rhinitis also increased when compared with allele G (OR=1.348, 95%CI: 1.036-1.754). Conclusion The SNP of pre-miR-146a(rs2910164)may be associated with susceptibility to allergic rhinitis in Chinese Han population, and its mutation sites may be the molecular markers of susceptibility of allergic rhinitis.

Key words: single-nucleotide polymorphisms, Allergic rhinitis, microRNA

CLC Number: 

  • R765.21
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