JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (5): 106-109.doi: 10.6040/j.issn.1673-3770.0.2016.073

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Efficacy of CO2 laser combined with proton pump inhibitors in the treatment of recurrent vocal process granuloma.

JIA Yanfeng, YANG Chunwei, SONG Fuchun, YANG Xiangli, WANG Lin, LIU Jixiang   

  1. Department of Otolaryngology, Tianjin Union Medical Centre, Tianjin 300121, China
  • Received:2016-02-26 Online:2016-10-20 Published:2016-10-20

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Abstract: Objective To observe the therapeutic effect of CO2 laser combined with proton pump inhibitor in the treatment of recurrent vocal fold granuloma. Methods The clinical data of 28 cases of recurrent vocal process granuloma treated in our hospital were retrospectively analyzed.Of all cases, 16 had gastroesophageal reflux symptoms, and 12 had no clear symptoms of gastroesophageal reflux. All patients underwent CO2 laser surgery under suspension laryngoscope, and then received anti acid reflux drug treatment with proton pump inhibitors for 8-12 weeks. Results The symptoms of hoarseness and foreign body sensationin all patients were obviously improved. The pathological results were granulation tissue. After one-year follow-up, all patients were examined with electron laryngoscope. The two recurrent cases orally took Esomeprazole 40 mg daily for one month. In one case, the granuloma significantly shrank; in the other case, the granuloma did not progress. Neither case received a second operation as they had no symptoms of hoarseness and foreign body sensation. Conclusion Acid reflux is an important factor of postoperative recurrence of vocal process granuloma; CO2 laser surgery combined with proton pump inhibitors is an effective treatment with advantages of small trauma and low recurrence rate.

Key words: Vocal process granuloma, Recurrence, CO2 laser, Gastroesophageal reflux, Proton pump inhibitors

CLC Number: 

  • R767.4
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