Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (1): 42-48.doi: 10.6040/j.issn.1673-3770.1.2018.016

• Research Progress • Previous Articles     Next Articles

Allergen inhalation challenge in the research of allergic rhinitis and asthma

Zheng ZHU,Wanjun WANG,Qiurong HU,Jing LI*()   

  1. Department of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, Guangdong, China
  • Received:2018-09-17 Online:2019-01-20 Published:2019-01-28
  • Contact: Jing LI E-mail:jingli1016@vip.163.com
  • Supported by:
    国家自然科学基金面上项目(81370129);国家自然科学基金重大研究计划培育项目(91542104);国家重点研发计划“精准医学研究”(2016YFC0905800);广州市科创局科学(技术)研究专项重点项目(201607020046);广东省科技发展专项资金(前沿与关键技术创新方向-重大科技专项)(2017B020226006)

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Abstract:

The prevalence of allergic disease is increasing in China with the progress of urbanization and the environmental and lifestyle changes. The pathogenesis of allergic rhinitis and asthma is currently believed to be mainly caused by the interaction of genetic and environmental factors, but the specific mechanisms are not fully understood yet. Chronic airway inflammation and airway hyperresponsiveness are typical pathophysiological features of allergic rhinitis and asthma. Natural exposure to allergens in the environment can induce exacerbation of the symptoms, cause increases in airway and systemic inflammation, and lead to increased airway hyperresponsiveness. Stimulation by inhalation of allergens in patients with allergic rhinitis and asthma can induce the onset of symptoms induced by natural allergen exposure, which can be used as a model for studying the pathogenesis of allergic rhinitis and asthma and to evaluate the efficacy of treatment drugs for both conditions. As they occur in the same airway and as a single disease, allergic rhinitis and asthma impact each other. The relationship between the upper and lower airways can be examined by stimulating one end and observing the reaction of the other end of the airways. House dust mites are one of the most common allergens and well related to the severity of allergic rhinitis and asthma in China, especially in the southern areas. In this review, we summarized the application of allergen nasal and bronchial provocation in the research of allergic rhinitis and asthma.

Key words: Allergen, Rhinitis, Asthma, Inhalation challenge, Airway responsiveness

CLC Number: 

  • R765.22
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