Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (3): 110-115.doi: 10.6040/j.issn.1673-3770.1.2021.165

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Research progress on health-related quality of life in allergic rhinitis

NI Jingzi1, WAN Wenjin1,2Overview,CHENG Lei1,2   

  1. 1. Department of Otorhinolaryngology;
    2. Clinical Allergy Center, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu, China
  • Published:2022-06-15

Abstract: As a common chronic inflammatory disease, allergic rhinitis has a significant negative impact on the sufferers' quality of life. In addition to nasal symptoms, patients may also suffer from ocular and even systemic symptoms, including fatigue, sleep disturbance, depression, anxiety, and other emotional disorders, including decreased work ethic and learning efficiency. In recent years, health-related quality of life(HRQoL)has gradually received attention as an important parameter. This paper reviews the clinical symptoms of allergic rhinitis and its specific effects on daily activities, emotion, sleep, and education of patients. We raise the point that clinicians should pay more attention to the patients' subjective disease burden, and we further show that it is necessary to strengthen the citizens' awareness of the quality of life burden caused by allergic rhinitis to facilitate an early diagnosis and treatment.

Key words: Allergic rhinitis, Symptoms, Quality of life, Health-related quality of life, Psychosomatic disorders

CLC Number: 

  • R765.21
[1] Seidman MD, Gurgel RK, Lin SY, et al. Clinical practice guideline: Allergic rhinitis[J]. Otolaryngol Head Neck Surg, 2015, 152(1 Suppl): S1-S43. doi:10.1177/0194599814561600.
[2] 金兴,胡大宇,朱丽,等.PM2.5与变应性鼻炎患者上气道阻力的相关性研究[J].山东大学耳鼻喉眼学报,2019,33(01):77-80.doi:10.6040/j.issn.1673-3770.0.2018.031. JIN Xing, HU Dayu, ZHU Li, et al. Correlation between PM2.5 and upper airway resistance in patients with allergic rhinitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 77-80. doi:10.6040/j.issn.1673-3770.0.2018.031.
[3] Schuler Iv CF, Montejo JM. Allergic rhinitis in children and adolescents[J]. Pediatr Clin North Am, 2019, 66(5): 981-993. doi:10.1016/j.pcl.2019.06.004.
[4] Cheng L, Chen JJ, Fu QL, et al. Chinese society of allergy guidelines for diagnosis and treatment of allergic rhinitis[J]. Allergy Asthma Immunol Res, 2018, 10(4): 300-353. doi:10.4168/aair.2018.10.4.300.
[5] Bousquet J, Dahl R, Khaltaev N. Global alliance against chronic respiratory diseases[J]. Eur Respir J, 2007, 29(2): 233-239. doi:10.1183/09031936.00138606.
[6] Meltzer EO. Allergic rhinitis: burden of illness, quality of life, comorbidities, and control[J]. Immunol Allergy Clin North Am, 2016, 36(2): 235-248. doi:10.1016/j.iac.2015.12.002.
[7] Mirabelli MC, Hsu J, Gower WA. Comorbidities of asthma in US children[J]. Respir Med, 2016, 116: 34-40. doi:10.1016/j.rmed.2016.05.008.
[8] Panek M, Mokros Ł, Pietras T, et al. The epidemiology of asthma and its comorbidities in Poland: Health problems of patients with severe asthma as evidenced in the Province of Lodz[J]. Respir Med, 2016, 112: 31-38. doi:10.1016/j.rmed.2016.01.009.
[9] Bousquet J, Khaltaev N, Cruz AA, et al. Allergic rhinitis and its impact on asthma(ARIA)2008 update(in collaboration with the World Health Organization, GA(2)LEN and AllerGen)[J]. Allergy, 2008, 63(Suppl 86): 8-160. doi:10.1111/j.1398-9995.2007.01620.x.
[10] Vandenplas O, Vinnikov D, Blanc PD, et al. Impact of rhinitis on work productivity: a systematic review[J]. J Allergy Clin Immunol Pract, 2018, 6(4): 1274-1286.e9. doi:10.1016/j.jaip.2017.09.002.
[11] Thanaviratananich S, Cho SH, Ghoshal AG, et al. Burden of respiratory disease in Thailand: Results from the APBORD observational study[J]. Medicine(Baltimore), 2016, 95(28): e4090. doi:10.1097/MD.0000000000004090.
[12] Yoo KH, Ahn HR, Park JK, et al. Burden of respiratory disease in Korea: an observational study on allergic rhinitis, asthma, COPD, and rhinosinusitis[J]. Allergy Asthma Immunol Res, 2016, 8(6): 527-534. doi:10.4168/aair.2016.8.6.527.
[13] Juniper EF, Guyatt GH. Development and testing of a new measure of health status for clinical trials in rhinoconjunctivitis[J]. Clin Exp Allergy, 1991, 21(1): 77-83. doi:10.1111/j.1365-2222.1991.tb00807.x.
[14] Blaiss MS, Meltzer EO, Derebery MJ, et al. Patient and healthcare-provider perspectives on the burden of allergic rhinitis[J]. Allergy Asthma Proc, 2007, 28(Suppl 1): S4-S10. doi:10.2500/aap.2007.28.2991.
[15] Schatz M. A survey of the burden of allergic rhinitis in the USA[J]. Allergy, 2007, 62(Suppl 85): 9-16. doi:10.1111/j.1398-9995.2007.01548.x.
[16] Long AA. Findings from a 1000-patient Internet-based survey assessing the impact of morning symptoms on individuals with allergic rhinitis[J]. Clin Ther, 2007, 29(2): 342-351. doi:10.1016/j.clinthera.2007.02.007.
[17] Hiraki N, Suzuki H, Udaka T, et al. Snoring, daytime sleepiness, and nasal obstruction with or without allergic rhinitis[J]. Arch Otolaryngol-Head Neck Surg, 2008, 134(12): 1254-1257. doi:10.1001/archotol.134.12.1254.
[18] Stull DE, Roberts L, Frank L, et al. Relationship of nasal congestion with sleep, mood, and productivity[J]. Curr Med Res Opin, 2007, 23(4): 811-819. doi:10.1185/030079907x178793.
[19] Bielory L, Skoner DP, Blaiss MS, et al. Ocular and nasal allergy symptom burden in America: the Allergies, Immunotherapy, and RhinoconjunctivitiS(AIRS)surveys[J]. Allergy Asthma Proc, 2014, 35(3): 211-218. doi:10.2500/aap.2014.35.3750.
[20] Meltzer EO, Blaiss MS, Naclerio RM, et al. Burden of allergic rhinitis: allergies in America, Latin America, and Asia-Pacific adult surveys[J]. Allergy Asthma Proc, 2012, 33(Suppl 1): S113-S141. doi:10.2500/aap.2012.33.3603.
[21] Meltzer EO, Blaiss MS, Derebery MJ, et al. Burden of allergic rhinitis: results from the Pediatric Allergies in America survey[J]. J Allergy Clin Immunol, 2009, 124(3 Suppl): S43-S70. doi:10.1016/j.jaci.2009.05.013.
[22] Young T, Finn L, Kim H, et al. Nasal obstruction as a risk factor for sleep-disordered breathing[J]. J Allergy Clin Immunol, 1997, 99(2): S757-S762. doi:10.1016/S0091-6749(97)70124-6.
[23] Udaka T, Suzuki H, Kitamura T, et al. Relationships among nasal obstruction, daytime sleepiness, and quality of life[J]. Laryngoscope, 2006, 116(12): 2129-2132. doi:10.1097/01.mlg.0000239111.24094.a3.
[24] Fisher LH, Davies MJ, Craig TJ. Nasal obstruction, the airway, and the athlete[J]. Clin Rev Allergy Immunol, 2005, 29(2): 151-158. doi:10.1385/CRIAI: 29: 2: 151.
[25] 曹瑞娟,许昱,陶泽璋,等.儿童变应性鼻炎患者症状及生活质量评估[J]. 临床耳鼻咽喉头颈外科杂志, 2010, 24(23):1071-1076.
[26] Klimek L, Eggers G. Olfactory dysfunction in allergic rhinitis is related to nasal eosinophilic inflammation[J]. J Allergy Clin Immunol, 1997, 100(2): 158-164. doi:10.1016/s0091-6749(97)70218-5.
[27] Stuck BA, Hummel T. Olfaction in allergic rhinitis: a systematic review[J]. J Allergy Clin Immunol, 2015, 136(6): 1460-1470. doi:10.1016/j.jaci.2015.08.003.
[28] Gupta N, Harit A, Taneja HC, et al. Olfaction and its correlates in allergic rhinitis: a case control study[J]. Indian J Otolaryngol Head Neck Surg, 2019, 71(suppl 3): 1782-1786. doi:10.1007/s12070-017-1149-7.
[29] Passàli GC, Ralli M, Galli J, et al. How relevant is the impairment of smell for the quality of life in allergic rhinitis?[J]. Curr Opin Allergy Clin Immunol, 2008, 8(3): 238-242. doi:10.1097/ACI.0b013e3282ffd6bb.
[30] Klossek JM, Annesi-Maesano I, Pribil C, et al. The burden associated with ocular symptoms in allergic rhinitis[J]. Int Arch Allergy Immunol, 2012, 158(4): 411-417. doi:10.1159/000334286.
[31] Smith AF, Pitt AD, Rodruiguez AE, et al. The economic and quality of life impact of seasonal allergic conjunctivitis in a Spanish setting[J]. Ophthalmic Epidemiol, 2005, 12(4): 233-242. doi:10.1080/09286580590967781.
[32] Devillier P, Bousquet PJ, Grassin-Delyle S, et al. Comparison of outcome measures in allergic rhinitis in children, adolescents and adults[J]. Pediatr Allergy Immunol, 2016, 27(4): 375-381. doi:10.1111/pai.12561.
[33] Blaiss MS. Important aspects in management of allergic rhinitis: compliance, cost, and quality of life[J]. Allergy Asthma Proc, 2003, 24(4): 231-238.
[34] Passali FM, Spinosi MC, Mignacco G, et al. Influence of allergic rhinitis in children and adolescents with recurrent headache[J]. Pol Otolaryngol, 2018, 72(2): 50-59. doi:10.5604/01.3001.0011.7252.
[35] Gryglas A. Allergic rhinitis and chronic daily headaches: is there a link?[J]. Curr Neurol Neurosci Rep, 2016, 16(4): 33. doi:10.1007/s11910-016-0631-z.
[36] Kalpaklioglu AF, Baççioglu A. Evaluation of quality of life: impact of allergic rhinitis on asthma[J]. J Investig Allergol Clin Immunol, 2008, 18(3): 168-173.
[37] Leynaert B, Neukirch C, Liard R, et al. Quality of life in allergic rhinitis and asthma. A population-based study of young adults[J]. Am J Respir Crit Care Med, 2000, 162(4 Pt 1): 1391-1396. doi:10.1164/ajrccm.162.4.9912033.
[38] Devillier P, Bousquet J, Salvator H, et al. In allergic rhinitis, work, classroom and activity impairments are weakly related to other outcome measures[J]. Clin Exp Allergy, 2016, 46(11): 1456-1464. doi:10.1111/cea.12801.
[39] Camelo-Nunes IC, Solé D. Allergic rhinitis: indicators of quality of life[J]. J Bras Pneumol, 2010, 36(1): 124-133. doi:10.1590/s1806-37132010000100017.
[40] Batlles-Garrido J, Torres-Borrego J, Rubí-Ruiz T, et al. Prevalence and factors linked to allergic rhinitis in 10 and 11-year-old children in Almería. Isaac Phase II, Spain[J]. Allergol Immunopathol(Madr), 2010, 38(3): 135-141. doi:10.1016/j.aller.2009.09.005.
[41] Scadding GK, Richards DH, Price MJ. Patient and physician perspectives on the impact and management of perennial and seasonal allergic rhinitis[J]. Clin Otolaryngol Allied Sci, 2000, 25(6): 551-557. doi:10.1046/j.1365-2273.2000.00417.x.
[42] Meltzer EO, Gross GN, Katial R, et al. Allergic rhinitis substantially impacts patient quality of life: findings from the Nasal Allergy Survey Assessing Limitations[J]. J Fam Pract, 2012, 61(2 Suppl): S5-S10.
[43] Romano M, James S, Farrington E, et al. The impact of perennial allergic rhinitis with/without allergic asthma on sleep, work and activity level[J]. Allergy Asthma Clin Immunol, 2019, 15: 81. doi:10.1186/s13223-019-0391-9.
[44] Lamb CE, Ratner PH, Johnson CE, et al. Economic impact of workplace productivity losses due to allergic rhinitis compared with select medical conditions in the United States from an employer perspective[J]. Curr Med Res Opin, 2006, 22(6): 1203-1210. doi:10.1185/030079906X112552.
[45] Adamia N, Jorjoliani L, Manjavidze N, et al. Psycho-emotional characteristics of the adolescents with allergic rhinitis[J]. Georgian Med News, 2015(243): 38-42.
[46] Sansone RA, Sansone LA. Allergic rhinitis: relationships with anxiety and mood syndromes[J]. Innov Clin Neurosci, 2011, 8(7): 12-17.
[47] Tanner LA, Reilly M, Meltzer EO, et al. Effect of fexofenadine HCI on quality of life and work, classroom, and daily activity impairment in patients with seasonal allergic rhinitis[J]. Am J Manag Care, 1999, 5(4):235-47.
[48] 岳胜清, 任贤灵, 罗通勇. 变应性鼻炎对患者负性情绪影响的研究[J]. 临床耳鼻咽喉头颈外科杂志, 2015,29(15): 1336-1339. doi:10.13201/j.issn.1001-1781.2015.15.004. YUE Shengqing, REN Xianling, LUO Tongyong. The influence of allergic rhinitis on negative emotion[J]. J Clin Otorhinolaryngol Head Neck Surg, 2015,29(15): 1336-1339. doi:10.13201/j.issn.1001-1781.2015.15.004.
[49] Sritipsukho P, Satdhabudha A, Nanthapisal S. Effect of allergic rhinitis and asthma on the quality of life in young Thai adolescents[J]. Asian Pac J Allergy Immunol, 2015, 33(3): 222-226. doi:10.12932/ap0548.33.3.2015.
[50] Yarrington A, Mehta P. Does sleep promote recovery after bone marrow transplantation?: a hypothesis[J]. Pediatr Transplant, 1998, 2(1): 51-55.
[51] Klossek JM, Gohler C, Vervloet D, et al. Epidemiology of seasonal spring-time allergic rhinitis in adults in France[J]. Presse Med, 2005, 34(5): 348-352. doi:10.1016/s0755-4982(05)83924-7.
[52] Krouse HJ, Davis JE, Krouse JH. Immune mediators in allergic rhinitis and sleep[J]. Otolaryngol Head Neck Surg, 2002, 126(6): 607-613. doi:10.1067/mhn.2002.125300.
[53] Leger D, Bonnefoy B, Pigearias B, et al. Poor sleep is highly associated with house dust mite allergic rhinitis in adults and children[J]. Allergy Asthma Clin Immunol, 2017, 13: 36. doi:10.1186/s13223-017-0208-7.
[54] Léger D, Annesi-Maesano I, Carat F, et al. Allergic rhinitis and its consequences on quality of sleep: an unexplored area[J]. Arch Intern Med, 2006, 166(16): 1744-1748. doi:10.1001/archinte.166.16.1744.
[55] Rimmer J, Downie S, Bartlett DJ, et al. Sleep disturbance in persistent allergic rhinitis measured using actigraphy[J]. Ann Allergy Asthma Immunol, 2009, 103(3): 190-194. doi:10.1016/S1081-1206(10)60180-9.
[56] Sundberg R, Torén K, Höglund D, et al. Nasal symptoms are associated with school performance in adolescents[J]. J Adolesc Health, 2007, 40(6): 581-583. doi:10.1016/j.jadohealth.2007.01.003.
[57] Wilken JA, Berkowitz R, Kane R. Decrements in vigilance and cognitive functioning associated with ragweed-induced allergic rhinitis[J]. Ann Allergy Asthma Immunol, 2002, 89(4): 372-380. doi:10.1016/s1081-1206(10)62038-8.
[58] Kim SY, Kim MS, Park B, et al. Allergic rhinitis, atopic dermatitis, and asthma are associated with differences in school performance among Korean adolescents[J]. PLoS One, 2017, 12(2): e0171394. doi:10.1371/journal.pone.0171394.
[59] Miyazaki C, Koyama M, Ota E, et al. Allergic diseases in children with attention deficit hyperactivity disorder: a systematic review and meta-analysis[J]. BMC Psychiatry, 2017, 17(1): 120. doi:10.1186/s12888-017-1281-7.
[60] Brawley A, Silverman B, Kearney S, et al. Allergic rhinitis in children with attention-deficit/hyperactivity disorder[J]. Ann Allergy Asthma Immunol, 2004, 92(6): 663-667. doi:10.1016/S1081-1206(10)61434-2.
[61] Yang MT, Chen CC, Lee WT, et al. Attention-deficit/hyperactivity disorder-related symptoms improved with allergic rhinitis treatment in children[J]. Am J Rhinol Allergy, 2016, 30(3): 209-214. doi:10.2500/ajra.2016.30.4301.
[62] 程雷. 变应性鼻炎的诊断和治疗[J]. 山东大学耳鼻喉眼学报, 2013,27(2): 1-4. doi:10.6040 /j.issn.1673-3770.1.2012.016.
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