Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (3): 104-109.doi: 10.6040/j.issn.1673-3770.0.2021.226

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Advances in the application of hyaluronic acid in chronic sinusitis

CAO XuanOverview,XIAO Xuping, LI Yunqiu   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, Hunan Provincial People's Hospital/The First Affiliated Hospital of Hunan Normal University, Changsha 410005, Hunan, China
  • Published:2022-06-15

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Abstract: In otolaryngology-head and neck surgery, chronic sinusitis is a common disease that affects 5%-12% of the population with a complex etiology and pathophysiological mechanism. Drug and surgical treatment for this disease are constantly being improved. Hyaluronic acid(HA), through various pathways, is widely used in clinical practice in patients with chronic rhinosinusitis(CRS). This paper aims to explain the possible mechanism of action of hyaluronic acid in CRS and its current application in achieving the treatment mode, as well as explore the possible future treatment mode of HA to improve the clinical treatment of CRS.

Key words: Hyaluronic acid, Chronic rhinosinusitis, Endoscopic sinus surgery, Bacterial biofilm

CLC Number: 

  • R765
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