JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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Treatment of allergic rhinitis by nebulized interferon gamma

LI Qin1, DU Ying-hua1, CHEN Yan-lin1, LIU Yu-gang2, ZHANG Da-liang3   

  1. 1. Department of Otorhinolaryngology, Linyi People′s Hospital, Linyi 276003；2. Department of Immunology, School of Medicine, Shandong University, Jinan 250012；3. Department of Otolaryngology & Head and Neck Surgery
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-02-24 Published:2007-02-24
  • Contact: LI Qin

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Abstract: Objective: To investigate the efficacy and mechanism of nebulized interferon gamma (IFN-r) in the prevention and treatment of allergic rhinitis. Methods: Ovalbumirl (OVA) absorbed to aluminum hydroxide was used to construct the allergic rhinitis model (group C), and nebulized IFN-r 12ug was inhaled once daily on day 23 to day 30. The nasal lavage fluid was collected on day 31, and the cellular constituents, levels of IL-4, IL-5 and IgE were determined. The normal control group (group A), the allergic rhinitic model group (group B) and beclomethasone dipropionate group (group D) consisted of five mice each. Results： Decrease of eosinophils (0.005±0.003)×104/ml was seen in nasal lavage fluid of group C as compared with group B［（0.223±0.068）×104/ml，(P<0.01)］, and the levels of IL-4(7.8±3.2pg/mL)　and IL-5(12.5±4.6pg/mL) decreased significantly in comparison with group B（P<0.01）. The serum levels of total IgE　(38.5±9.6ug/ml) and ovalbuminspecific IgE(19.6±5.2U/mL )decreased significantly in comparison with those of group B（P<0.01）. Conclusion： IFN-r can inhibit the composition of IL-4 and IL-5, and inhibit the airway inflammation with eosinophilic infiltration and the serum levels of total IgE and ovalbumin specific IgE, and so it is helpful in prevention and treatment of allergic rhinitis.

Key words: Allergic rhinitis, Interferon gamma, Nebulized, Treatment outcome

CLC Number: 

  • R765.21
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