Abstract: Objective To investigate the distribution of serum specific IgE(sIgE)in polysensitized children with allergic rhinitis(AR)in Dalian. Methods Retrospectively analyzed the sIgE results of 272 polysensitized pediatric AR patients, grouped by sex, age, allergen type and intensity, number and intensity of inhaled and ingested allergens, to compare the distribution of allergens between groups. Results Pearson correlation analysis(r=0.587, P=0.035)showed that polysensitization was positively correlated with age in all AR children, and the intensity was higher. Spearman's correlation analysis(r=-0.913, P<0.001)showed a negative correlation between the number of allergen species and the corresponding number of patients, and the intensity was higher. Based on age, the patients were divided into 3 groups, 2-5 years, 5-9 years, and 10-14 years. There was a negative correlation between the allergen-positive cases and number of allergen species in each group, and the intensity was higher. The top 5 allergen-positive cases were house dust mite/powder mite, Artemisia, cat, egg white and common ragweed. Based on age, there was a significant difference in the frequency of inhalational and ingestion allergens between the 6-9 years old group(t=2.275, P=0.048). There was significant difference in average strength between inhalation and ingestion allergens(t=2.361, P=0.035). There was a significant difference in average strength between inhalatant and ingestant allergens in the 10-14 years old group(t=3.658, P=0.002). The differences in spring, autumn and year-round among inhalatant allergens were not statistically significant in the number, total intensity and mean intensity. Conclusion As children get older and Increased types of contact allergens, the number of children with polysensitization will also increase. Allergen testing needs to be rechecked regularly. Dermatophagoides farinae / Dermatophagoides farinae, Artemisia argyi, cat, egg white and common ragweed are the main allergens of AR children with polysensitization in Dalian, and attention should be paid to prevention and control. The sensitization of ingestant allergens should be paid attention to at the age of 6-9.

Key words: Children, Allergic rhinitis, Allergen, Specific IgE, Polysensitization