Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (3): 143-148.doi: 10.6040/j.issn.1673-3770.0.2022.254

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Mechanism and clinical applications of subthreshold diode micropulse laser

TANG Huixin, LI Jingjing, ZOU Hong   

  1. Department of Ophthalmology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • Published:2023-05-24

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Abstract: The subthreshold diode micropulse laser(SDML)is a multiple repeated energy micropulse emitted by multiple thresholds within a short time. Currently, it can be used in retinal diseases, such as diabetic retinopathy, central serous chorioretinopathy, and retinal vein occlusion macular edema. The SDML can preserve the visual contrast sensitivity better than the traditional laser, reducing the risks of subretinal fibrosis and scar formation. The current research shows that it can selectively act on the retinal pigment epithelial, improve the function of Müller cells, inactivate microglia, reduce the expression of inflammatory factors such as the vascular endothelial growth factor, and up-regulate the expression of protective factors such as the pigment epithelium-derived factor to inhibit the formation of neovascularization and reduce macular edema to protect retinal function and preserve patients' vision. However, problems still exist in its clinical applications, such as the nonstandardization of the energy, time, density, and other parameters of SDML treatment and the unclear molecular mechanism. Therefore, further clinical trials and basic experimental studies are required. The purpose of this study is to review the molecular mechanism and current clinical applications of SDML to provide a reference for the clinical applications of SDML

Key words: Subthreshold diode micropulse laser, Molecular mechanism, Clinical application, Diabetic retinopathy, Central serous chorioretinopathy, Retinal vein occlusion

CLC Number: 

  • R774.1
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