Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2024, Vol. 38 ›› Issue (2): 13-17.doi: 10.6040/j.issn.1673-3770.0.2023.044

• Original Article • Previous Articles     Next Articles

Analysis of clinical characteristics of vaccine-associated uveitis: a retrospective study based on American vaccine adverse event reporting system

HOU Ning1, YANG Junxing2, ZHANG Yupeng1, LIN Zichun1, DENG Aijun2   

  1. 1. Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Shandong Second Medical University, Weifang 261000, Shandong, China2. Ophthalmic Center, Affiliated Hospital of Shandong Second Medical University, Weifang 261000, Shandong, China
  • Online:2024-03-20 Published:2024-03-29

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Abstract: Objective To investigate the clinical characteristics of vaccine-associated uveitis in order to provide a reference for vaccine safety monitoring, vaccination, and clinical diagnosis and treatment. Methods The vaccine-associated uveitis reports from 1990 to 2022 were collected from the American Vaccine Adverse Event Reporting System. Moreover, sex, age, type of vaccination, dose series, time of occurrence, and type of uveitis of vaccine-associated uveitis reports were retrospectively analyzed. Results Of the 317 cases of vaccine-associated uveitis, more than 10 types of vaccine were involved, mainly the COVID-19 vaccine, human papillomavirus vaccine, and hepatitis B vaccine. There were 86 males and 231 females, with a male-to-female ratio of 1:2.7. Patients aged 18-<60 years, accounted for the majority of the total cases(65.3%). Uveitis is common under 8 days after vaccination and after the first dose of vaccination, accounting for 56.8% and 47.0%, respectively. Iridocyclitis represented the highest proportion of 184(56.5%)cases of uveitis. Conclusion Fully understand and study this adverse reaction to vaccination in depth, continue to monitor vaccine safety, better vaccination, and clinical diagnosis and treatment.

Key words: Vaccine, Uveitis, Vaccine adverse event reporting system, Adverse reaction

CLC Number: 

  • R773
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