Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2026, Vol. 40 ›› Issue (6): 46-53.

• Airway Allergic Diseases: From Mechanism to Practice • Previous Articles    

The correlation between the expression of IL-8, IFN-γ and systemic inflammatory index in CRSwNP patients and its clinical significance

WANG Yunuo1, LI Zhenglin1, ZHAO Jiaxian1, LI Wenkai1, LU Hui1, WU Jingfang1, XUE Gang2   

  1. 1. Basic Medical College;
    2. First Clinical College, HeiBei North University, Zhangjiakou 075000, Hebei, China
  • Published:2026-11-03

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Abstract: Objective The present study aims to explore the morphological configuration and inflammatory factor expression of CRSwNP in the Zhangjiakou area. In particular, it will analyze the expression of IL-8 and IFN-γ in CRSwNP, as well as its relationship and significance with systemic inflammatory index. Methods A total of 135 patients dignosed with CRSwNP who underwent rhinoscopic surgery at the Department of Otorhinolaryngology Head and Neck Surgery of the First Affiliated Hospital of Hebei North University from 8 January 2021 to 8 December 2024 were included in the study(CRSwNP group). Nasal polyp tissues and plasma from these patients were collected for analysis. In order to establish a basis for comparison, normal uncinate process tissues and plasma from patients diagnosed with maxillary sinus cysts during the same period(57 cases)were taken as a control group(control group).The control group was stained with hematoxylin and eosin(HE)and immunohistochemistry(IHC)to observe the morphology of sinus mucosa and the distribution of inflammatory cells. Furthermore,Western blot and enzyme-linked immunosorbent assay(ELISA)were used to detect the expression and semi-quantitative analysis of inflammatory cell markers, interleukin(IL)-8 and interferon(IFN)-γ. ROC analysis was employed to evaluate the diagnostic value of systemic inflammation index, IL-8 and IFN-γ, both individually and in combination, for the diagnosis of CRSwNP. Results The study revealed that CRSwNP tissues exhibited epithelial hyperplasia and hypertrophy, accompanied by squamous epithelial hyperplasia, eosinophil, neutrophil, lymphocyte and plasma cell infiltration in the mesenchyme, and markedly edematous connective tissues. The results of the IHC analysis demonstrated that the AOD values of IL-8, IFN-γ, CD138, CD3, CD79a, and CD68 in the CRSwNP group were significantly higher compared with those in the control group(P<0.05). The results of IL-8 and IFN-γ in CRSwNP tissues were significantly higher than those in the control group by Western blot (P<0.001); In addition, the ELISA assay results showed that the plasma levels of IL-8 and IFN-γ in the CRSwNP group were significantly higher than those in the control group(P<0.001). ROC curve analysis showed that the area under the curve of LMR, plasma IL-8 and IFN-γ in the diagnosis of CRSwNP was 0.656(95%CI:0.509-0.802), 0.894(95%CI:0.809-0.978)and 0.731(95%CI:0.570-0.893), respectively. The area under the curve of the combined diagnosis of CRSwNP was 0.981(95%CI:0.955-0.999 ). Conclusion CRSwNP was predominantly of mixed inflammation(especially neutrophilic type), with high expression of IL-8 and IFN-γ; the combined diagnosis of LMR, IFN-γ and IL-8 significantly improved the diagnostic efficacy of CRSwNP in the Zhangjiakou area.

Key words: Chronic rhinosinusitis with nasal polyps, Interleukin-8, Interferon-γ, Systemic inflammation index

CLC Number: 

  • R765.4
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