ISSN 1673-3770 CN 37-1437/R
Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2026, Vol. 40 ›› Issue (6): 70-75.
• Airway Allergic Diseases: From Mechanism to Practice • Previous Articles
SU Yilin1, XUE Jinmei1,2
CLC Number:
| [1] Busse W W, Kraft M, Rabe K F, et al. Understanding the key issues in the treatment of uncontrolled persistent asthma with type 2 inflammation[J]. Eur Respir J, 2021, 58(2): 2003393. DOI: 10.1183/13993003.03393-2020 [2] Kim B, Rothenberg M E, Sun X, et al. Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms, and therapeutic targets in atopic diseases[J]. J Allergy Clin Immunol, 2024, 153(4): 879-893. DOI: 10.1016/j.jaci.2023.08.017 [3] Giombi F, Pace G M, Pirola F, et al. Airways type-2 related disorders: multiorgan, systemic or syndemic disease?[J]. Int J Mol Sci, 2024, 25(2): 730. DOI: 10.3390/ijms25020730 [4] Gavia-García G, Rosado-Pérez J, Arista-Ugalde T L, et al. Telomere length and oxidative stress and its relation with metabolic syndrome components in the aging[J]. Biology(Basel), 2021, 10(4): 253. DOI: 10.3390/biology10040253 [5] Jones-Weinert C, Mainz L, Karlseder J. Telomere function and regulation from mouse models to human ageing and disease[J]. Nat Rev Mol Cell Biol, 2025, 26(4): 297-313. DOI: 10.1038/s41580-024-00800-5 [6] 赵兵, 周斌. 人胃黏膜端粒功能障碍与慢性萎缩性胃炎的相关性研究[J]. 中华消化杂志, 2023, 43(1): 4751. DOI: 10.3760/cma.j.cn311367-20220921-00468 [7] Glorieux C, Liu S H, Trachootham D, et al. Targeting ROS in cancer: rationale and strategies[J]. Nat Rev Drug Discov, 2024, 23(8): 583-606. DOI: 10.1038/s41573-024-00979-4 [8] Shim H S, Iaconelli J, Shang X Y, et al. TERT activation targets DNA methylation and multiple aging hallmarks[J]. Cell, 2024, 187(15): 4030-4042.e13. DOI: 10.1016/j.cell.2024.05.048 [9] Piñeiro-Hermida S, Martínez P, Blasco M A. Short and dysfunctional telomeres protect from allergen-induced airway inflammation[J]. Aging Cell, 2021, 20(5): e13352. DOI: 10.1111/acel.13352 [10] Smith E M, Pendlebury D F, Nandakumar J. Structural biology of telomeres and telomerase[J]. Cell Mol Life Sci, 2020, 77(1): 61-79. DOI: 10.1007/s00018-019-03369-x [11] Mir S M, Samavarchi Tehrani S, Goodarzi G, et al. Shelterin complex at telomeres: implications in ageing[J]. Clin Interv Aging, 2020, 15: 827-839. DOI: 10.2147/CIA.S256425 [12] Heba A C, Toupance S, Arnone D, et al. Telomeres: New players in immune-mediated inflammatory diseases?[J]. J Autoimmun, 2021, 123: 102699. DOI: 10.1016/j.jaut.2021.102699 [13] Lin J, Epel E. Stress and telomere shortening: insights from cellular mechanisms[J]. Ageing Res Rev, 2022, 73: 101507. DOI: 10.1016/j.arr.2021.101507 [14] Lex K, Maia Gil M, Lopes-Bastos B, et al. Telomere shortening produces an inflammatory environment that increases tumor incidence in zebrafish[J]. Proc Natl Acad Sci USA, 2020, 117(26): 15066-15074. DOI: 10.1073/pnas.1920049117 [15] Xue J M, Liu Z Z, Liao Y, et al. Undersized telomeres in regulatory T cells link to the pathogenesis of allergic rhinitis[J]. iScience, 2023, 27(1): 108615. DOI: 10.1016/j.isci.2023.108615 [16] Sies H, Jones D P. Reactive oxygen species(ROS)as pleiotropic physiological signalling agents[J]. Nat Rev Mol Cell Biol, 2020, 21(7): 363-383. DOI: 10.1038/s41580-020-0230-3 [17] 周颖东, 张梦娴, 王青玲, 等. 氧化应激在老年性聋发病机制中的研究进展[J]. 山东大学耳鼻喉眼学报, 2024, 38(1): 72-78,91. DOI: 10.6040/j.issn.1673-3770.0.2022.518 [18] Zhang J, Wei Y H, Yue Y B, et al. RIPK4 promotes oxidative stress and ferroptotic death through the downregulation of ACSM1[J]. Proc Natl Acad Sci USA, 2024, 121(40): e2410628121. DOI: 10.1073/pnas.2410628121 [19] 中华医学会变态反应学分会. 2型炎症性疾病机制及靶向治疗专家共识[J]. 中华医学杂志, 2022, 102(42): 3349-3373. DOI: 10.3760/cma.j.cn112137-20220628-01431 [20] Zang Y, Liu S R, Rao Z B, et al. Retinoid X receptor gamma dictates the activation threshold of group 2 innate lymphoid cells and limits type 2 inflammation in the small intestine[J]. Immunity, 2023, 56(11): 2542-2554. DOI: 10.1016/j.immuni.2023.08.019 [21] Vlaykov A N, Tacheva T T, Vlaykova T I, et al. Serum and local IL-4, IL-5, IL-13 and immunoglobulin E in allergic rhinitis[J]. Postepy Dermatol Alergol, 2020, 37(5): 719-724. DOI: 10.5114/ada.2020.100483 [22] Chakravarti D, Hu B L, Mao X Z, et al. Telomere dysfunction activates YAP1 to drive tissue inflammation[J]. Nat Commun, 2020, 11(1): 4766. DOI: 10.1038/s41467-020-18420-w [23] Lanna A, Vaz B, D'Ambra C, et al. An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory[J]. Nat Cell Biol, 2022, 24(10): 1461-1474. DOI: 10.1038/s41556-022-00991-z [24] Chakravarti D, LaBella K A, DePinho R A. Telomeres: history, health, and hallmarks of aging[J]. Cell, 2021, 184(2): 306-322. DOI: 10.1016/j.cell.2020.12.028 [25] Dong H, Xia Y Y, Jin S L, et al. Nrf2 attenuates ferroptosis-mediated IIR-ALI by modulating TERT and SLC7A11[J]. Cell Death Dis, 2021, 12(11): 1027. DOI: 10.1038/s41419-021-04307-1 [26] Gao X Y, Yu X, Zhang C, et al. Telomeres and mitochondrial metabolism: implications for cellular senescence and age-related diseases[J]. Stem Cell Rev Rep, 2022, 18(7): 2315-2327. DOI: 10.1007/s12015-022-10370-8 [27] Miwa S, Kashyap S, Chini E, et al. Mitochondrial dysfunction in cell senescence and aging[J]. J Clin Invest, 2022, 132(13): e158447. DOI: 10.1172/JCI158447 [28] Chen Z, Han F F, Du Y, et al. Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions[J]. Signal Transduct Target Ther, 2023, 8(1): 70. DOI: 10.1038/s41392-023-01332-8 [29] Lee J H, Paull T T. Cellular functions of the protein kinase ATM and their relevance to human disease[J]. Nat Rev Mol Cell Biol, 2021, 22(12): 796-814. DOI: 10.1038/s41580-021-00394-2 [30] Batsios G, Taglang C, Gillespie A M, et al. Imaging telomerase reverse transcriptase expression in oligodendrogliomas using hyperpolarized δ-[1-13C] -gluconolactone[J]. Neurooncol Adv, 2023, 5(1): vdad092. DOI: 10.1093/noajnl/vdad092 [31] Wiley C D, Campisi J. The metabolic roots of senescence: mechanisms and opportunities for intervention[J]. Nat Metab, 2021, 3(10): 1290-1301. DOI: 10.1038/s42255-021-00483-8 [32] Reis J, Gorgulla C, Massari M, et al. Targeting ROS production through inhibition of NADPH oxidases[J]. Nat Chem Biol, 2023, 19(12): 1540-1550. DOI: 10.1038/s41589-023-01457-5 [33] Niu B Y, Liao K X, Zhou Y X, et al. Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy[J]. Biomaterials, 2021, 277: 121110. DOI: 10.1016/j.biomaterials.2021.121110 [34] Maniaci A, Via L L, Lechien J R, et al. Hearing loss and oxidative stress: a comprehensive review[J]. Antioxidants(Basel), 2024, 13(7): 842. DOI: 10.3390/antiox13070842 [35] Li J, Xu P L, Chen S S. Research progress on mitochondria regulating tumor immunity[J]. Zhejiang Da Xue Xue Bao Yi Xue Ban, 2024, 53(1): 1-14. DOI: 10.3724/zdxbyxb-2023-0484 [36] Wang Y, Yuan H L, Shen D, et al. Artemisinin attenuated ischemic stroke induced pyroptosis by inhibiting ROS/TXNIP/NLRP3/Caspase-1 signaling pathway[J]. Biomed Pharmacother, 2024, 177: 116894. DOI: 10.1016/j.biopha.2024.116894 [37] 刘玉卓, 吕威, 王威清. 单细胞转录组测序技术在呼吸道2型炎性疾病中的研究进展[J]. 中华耳鼻咽喉头颈外科杂志, 2023, 58(12): 1266-1271. DOI: 10.3760/cma.j.cn115330-20230413-00169 [38] 韩晋博, 王威清, 朱真真, 等. 慢性鼻窦炎的鼻腔黏膜上皮细胞研究进展[J].中华耳鼻咽喉头颈外科杂志, 2022, 57(1): 78-81. DOI: 10.3760/cma.j.cn115330-20210303-00103 [39] Rehman R, Jaiswal A, Agrawal A, et al. Ku70 modulation alleviates murine allergic asthma features and restores mitochondrial function in lungs[J]. Mitochondrion, 2021, 57: 76-87. DOI: 10.1016/j.mito.2020.12.005 [40] Chang-Chien J, Kuo M L, Tseng Y L, et al. Differential effects of long- and short-term exposure to PM2.5 on accelerating telomere shortening: from in vitro to epidemiological studies[J]. Ecotoxicol Environ Saf, 2024, 281: 116650. DOI: 10.1016/j.ecoenv.2024.116650 [41] Guo Q, Jin Y Z, Chen X Y, et al. NF-κB in biology and targeted therapy: new insights and translational implications[J]. Signal Transduct Target Ther, 2024, 9(1): 53. DOI: 10.1038/s41392-024-01757-9 [42] Karadogan B, Beyaz S, Gelincik A, et al. Evaluation of oxidative stress biomarkers and antioxidant parameters in allergic asthma patients with different level of asthma control[J]. J Asthma, 2022, 59(4): 663-672. DOI: 10.1080/02770903.2020.1870129 [43] Nagasaki T, Schuyler A J, Zhao J M, et al. 15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation[J]. J Clin Invest, 2022, 132(1): e151685. DOI: 10.1172/JCI151685 [44] Wang X F, Xu W J, Wang F F, et al. Telomere length and development of systemic lupus erythematosus: a mendelian randomization study[J]. Arthritis Rheumatol, 2022, 74(12): 1984-1990. DOI: 10.1002/art.42304 |
| [1] | ZHOU Jiayao, ZHU Ying, HU Huilin, LI Zhipeng, LIN Hai, TANG Ru, MAO Song, GU Yuelong, ZHAO Yue, ZHANG Weitian. Nasal epithelial cell injury and fibroblast inflammatory phenotype activation induced by PM2.5 organic components [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(6): 10-21. |
| [2] | HU Huixuan, PAN Li, LIAO Wenxi, FENG Yan. Efficacy and compliance of Artemisia annua pollen allergen sublingual drops in the treatment of monosensitized and polysensitized allergic rhinitis patients [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(6): 22-29. |
| [3] | LIANG Shaoqin, LIN Xinsheng, LI Jiajia. Effects of a three-dimensional intervention based on the health belief model on chronic rhinosinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(6): 30-39. |
| [4] | SHENG Xinyue, ZHANG Biaoxin, LIU Yehai, WU Feihu, CAI En, XU Jing. Efficacy observation of acupoint massage combined with auricular acupressure in the treatment of moderate to severe persistent allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(6): 40-45. |
| [5] | WANG Yunuo, LI Zhenglin, ZHAO Jiaxian, LI Wenkai, LU Hui, WU Jingfang, XUE Gang. The correlation between the expression of IL-8, IFN-γ and systemic inflammatory index in CRSwNP patients and its clinical significance [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(6): 46-53. |
| [6] | LIU Danfeng, PAN Qingchun, FENG Xuefei, LI Haoyi, REN Jian, LI Daibo. Development and validation of a nomogram for predicting asthma comorbidity in elderly patients with allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(6): 54-62. |
| [7] | TANG Yuchen, WANG Yan, TAO Zezhang. Research progress of Toll-like receptors in allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(6): 63-69. |
| [8] | LI Qi, GU Qinglong. Current status and prospect of pediatric otolaryngology-head and neck surgery in China [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(5): 11-17. |
| [9] | ZHU Bin, LIU Di, JIAO Cheng, YAN Qi, WANG Ying, GUAN Bing, MA Wei, XU Li, CAO Qing. The current situation and frontiers of chronic sinusitis research in children: visual analysis based on CiteSpace [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(5): 37-52. |
| [10] | ZHAO Xinghe, JIA Guangbiao, YIN Depei, ZHU Baolian, DOU Xunwu, LI Qiang. Combined endoscopic and microscopic treatment of a middle ear teratoma in an infant:a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(5): 78-83. |
| [11] | WU Bo, YAN Bin, TANG Yong. Evaluation of postoperative efficacy and analysis of prognostic factors in chronic sinusitis patients undergoing functional endoscopic sinus surgery in the "internet+"medical model [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(5): 94-102. |
| [12] | XIANG Lan, GU Jia, QIN Qing, LIU Xuewei, ZHAO Xuezhang. Analysis of the efficacy of high-concentration glucocorticoid-soaked gelatin sponge nasal packing after endoscopic surgery for chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(4): 37-44. |
| [13] | FENG Sicong, YU Xiaolan, LOU Dan. Evaluation of the effect of Messerklinger middle turbinate plasty on chronic rhinosinusitis with nasal polyps based on the expression of Ki67 and GM-CSF in vesicular tissue [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(3): 31-39. |
| [14] | WANG Zhiyuan, HAO Zhongkai, ZHANG Chenming. The effect of local micro-pressure oxygen on the repair and oxidative stress of rabbit corneal epithelial cells after injury [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(3): 80-86. |
| [15] | WANG Kaijian, WANG Wei, CHEN Xuesheng, FAN Chunsun, HE Yingying, HUANG Dongling, QIAN Cunhui, DING Shujun. Correlation between neutrophil-to-lymphocyte ratio with hearing loss and audiometric thresholds in adults: a cross-sectional study based on NHANES [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(2): 18-28. |
|
||