Abstract: To investigate the infective rate of methicillin-resistant staphylococcus(MRS) and its resistance characteristics so as to provide a basis for the clinically rational use of anti-microbial agents and an effective control of MRS infections. Methods:　Strains of staphylococcus from clinical samples were determined by a disc agar diffusion method and MRS agar plate screening. At the same time their resistance to 20 different anti-microbial agents and the presence of β-lactamase in the strains were determined. Results： Twenty-seven strains of MRSA and thirty-three strains of MRSCoN were identified. The proportion of MRSA and MRSCoN was 37.6% and 38.3%, respectively. The incidence of MRSA and MRSCoN producing βlactamase was 77.8% and 72.7% ,respectively. The resistance rate showed a significant difference between the MRS and the MSS(P<0.05).The multi-resistance ranged from 6 to 17 and 5 to 15 antibiotics in MRSA and MRSCoN. Conclusions: Vancomycin, Rifampin and Amikacin have effective antibacterial activity against MRS. Vancomycin is the first choice for MRS infections. Wide attention should be paid to the multi-resistance of MRS, and the use of antibiotics should be better managed and the resistance of MRS to antibiotics should be further monitored.

Key words: Chronic nasosinusitis, Methicillin resistance, 　Staphylococcus, Antibiotics