JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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Radio-sensitization of Oridonin on nasopharyngeal carcinoma cell line CNE-2

XIAO Da-jiang1，ZHU Guo-chen1，WANG Xiao-lan2   

  1. 1.Department of Otolaryngology,Wuxi Second People's Hospital,Nanjing Medical University,Wuxi 214002,Jiangsu;2.Department of Pharmacology,Medical College of Southern Yangtze University,Wuxi 214002
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-04-24 Published:2007-04-24
  • Contact: XIAO Da-jiang

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Abstract: Objective: To observe the radio-sensitization of Oridonin and its mechanism on nasopharyngeal carcinoma cell line CNE-2. Methods： The radiation sensitization enhancement ratio（SER） was determined by clonogenic assay. Cell cycle distribution was assessed by flow cytometry. Results： The SER was 1.227. The rate of G2/M phase block related to the Oridonin group, the radiotherapy group and the combination treatment group was 17.8%, 24.7% and 45.2%, respectively. Conclusion： Oridonin can enhance radiosensitition for CNE-2 cells, which maybe relate a to changes of the cell cycle.

Key words: Oridonin, Nasopharyngeal carcinoma, Radiosensitization

CLC Number: 

  • R739.62
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