J Otolaryngol Ophthalmol Shandong Univ ›› 2013, Vol. 27 ›› Issue (6): 35-37.doi: 10.6040/j.issn.1673-3770.0.2013.133

• Articles • Previous Articles     Next Articles

Expression of MCP-1 and BMP-7 in auricular keloid

JIN Jian-ping     

  1. Department of Otorhinolaryngology Head and Neck Surgery, The First Hospital of Wujiang Distriction, Medical School of Nantong University, Suzhou 215200, Jiangsu, China
  • Received:2013-04-28 Published:2013-12-16

PDF (PC)

1269

Abstract:

Objective    To explore the roles of MCP-1 and BMP-7 in the formation of auricular keloids. Methods    Immunohistochemistry method was used to detect MCP-1 and BMP-7 expression in 29 cases of auricular keloid tissues and 22 cases of normal skin tissue. The correlation between MCP-1 and BMP-7 expression in auricular keloid tissues was discussed. Results    The positive rate of MCP-1in auricular keloids group was 82.76%, which was significantly higher than that of non-pathological scar group (28.57%) and the control group(9.09%) (χ2=12.033, 24.350;  all P＜0.05); The positive rate of BMP-7 in keloids group was 17.24%, which was significantly lower than that of non-pathological scar group (57.14%) and the control group(81.82%) (χ2=9.442, 18.432; all P＜0.05). A negative correlation between MCP-1 and BMP-7 expression of auricular keloid tissues was noted(r=-0.538，P＜0.05). Conclusion    MCP-1 and BMP-7 participate in the regulation of auricular keloid formation process.  BMP-7 can be used as an ideal target in gene therapy to prevent keloids.

Key words: MCP-1, Auricular keloid, Expression, BMP-7

CLC Number: 

  • R764.1
[1] ZHAO Jincheng, SHI Ying, ZHANG Ying, JIA Zhanhong, MA Xin, ZHANG Jingqiu, WU Zaijun, WANG Yu. Expression and methylation patterns of CDH13 in human head and neck squamous carcinoma cells. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 60-63.
[2] LI Xue-zhen1， JIN Xiao-ming1， LIU Min-sheng2. Expression and clinicopathological significance of Notch-1，NF-kB and  β-catenin in oral squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(1): 9-13.
[3] L Mei1， DONG Pin2， SHE Cui-ping3， DU Cui-ping1， LI Yong1， XU Er-dong1. Differentially expressed genes in 3 cases of hypopharyngeal carcinoma and  normal tissues by cDNA microarray [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2010, 24(5): 5-.
[4] HUANG Fang, KANG Rui. Abnormal expression of PI3Kp85 in nasopharyngeal carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2009, 23(3): 17-20.
[5]

ZHANG Jian-li,WANG Yue-jian,CHEN Wei-xiong,HU Wei-wei,LI Guang-min

.

Immunohistochemistry and serial section in detection of lymph node micrometastasis of head and neck squamous cell carcinoma

[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(4): 299-303 .
[6] LIU Rui,SHI Wen-jie,LIU Ji-xiang . Differentially expressed genes in laryngeal squamous cell carcinoma and normal tissue by cDNA microarray [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2007, 21(1): 68-70 .
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd