Abstract: Objective To investigate the effect of Budesonide after functional endoscopic sinus surgery (FESS) for chronic nasal-sinusitis. Methods A total of 280 cases of chronic nasal-sinusitis(CRS) which underwent FESS were randomly divided into two groups: A group was regular dressing group with Budesonide nasal spray; B group was put gelatin sponge with Budesonide infiltration at vesicles and edema place in the post-operative dressing process, 1-2 times a week. Then we adopted VAS visual assessment and Lund-Kennedy assessment to assess the dressing effect after one, three and six months of FESS. Results The VAS scores and Lund-Kennedy scores of A and B groups at 1, 3 and 6 months were 4.48±1.33, 2.16±0.81, 2.04±0.96; 3.85±1.09,1.90±0.88,1.93±0.74 and 11.44±1.73, 4.51±1.05,3.94±0.86; 6.82±2.08,4.26±1.17,2.17±0.79. The VAS score at the three time points was statistically significant between the two groups (P<0.05); The VAS score of the 3 and 6 months was statistically significant with that of 1 month(P<0.05); while it was not statistically significant between the 3 and 6 months. The Lund-Kennedy score at 1 and 6 months was statistically significant between the two groups (P<0.05); The Lund-Kennedy score at 3 and 6 months was statistically significant (P<0.05); while between 3 months and 6 months, it was statistically significant in the A group, but not in the B group. Conclusion Budesonide after FESS of CRS can better reduce vesicle formation, mitigate edema and promote mucosal epithelium.

Key words: Nasal-sinusitis, chronic, Budesonide suspension, Functional endoscopic sinus surgery