JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2014, Vol. 28 ›› Issue (4): 1-5.doi: 10.6040/j.issn.1673-3770.0.2014.235

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New advance in sleep disorders of Alzheimer’s disease

HE Ying-xue, CONG Lin, DU Yi-feng   

  1. Department of Neurology, Shandong Provincal Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Received:2014-06-01 Online:2014-08-16 Published:2014-08-16

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Abstract: The incidence of sleep disorder is high in patients with Alzheimer's disease. It is characterized by the increase of nocturnal awakenings and sleep time during the day. Polysomnography shows the stage 3, 4 and REM sleep time decrease and the number of WASO(wake after sleep onset) increases. The main types of sleep disorder in AD patients are sleep disordered breathing, sleep-wake cycle disorders, restless leg syndrome, hypersomnia and sundowning.The sleep disorders occur in AD patients via the following principal mechanisms: the deposition of Aβ in brain and the degeneration of suprachiasmatic nucleus and nucleus basalis of Meynert. The sleep disorders are mainly related to the following aspects: gender, physiological function, degree of dementia, psychiatric syndromes and the use of hyptonic agents. Cholinesterase inhibitors, melatonin, behavior therapy, continuos positive airway pressure have been reported effective against sleep disorders, while they need to be proven in larger clinical studies. Sleep disorder is a common manifestation in AD patients, generated by brain neuronal degenerations, and are affected by many factors. However, there is little confirmed effective therapy for sleep disorder.Therefor,further researches are needed for its prevention and treatment.Relevant literatures about sleep disorder in AD patients at home and abroad are reviewed in this paper.

Key words: Sleep disorder, Sleep-wake cycle disorders, Affective factor, Sleep disordered breathing, Alzheimer’s disease

CLC Number: 

  • R741
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