Abstract: Objective To explore the levels of creatine kinase (CK), creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH) and uric acid (UA) in patients with severe obstructive sleep apnea hypopnea syndrome (OSAHS) complicated with hypertension. Methods A total of 140 OSAHS cases were divided into simple OSAHS group (n=67) and OSAHS complicated with hypertension group (n=23, OSAHS+HT group), 30 patients with simple hypertension were included into the hypertension group, and 20 healthy people served as controls. The levels of CK, CK-MB, LDH and UA of the 4 groups were measured. The rates of abnormal cardiac structure and function in OSAHS group and OSAHS+HT group were analyzed. Results Compared with the control group, the levels of CK, CK-MB, LDH and UA in the other 3 groups were higher (P<0.05, or P<0.01). Compared with simple OSAHS group, the levels of CK, LDH and UA in OSAHS+HT group were higher (P<0.05), but the level of CK-MB had no significant difference (P>0.05). The incidence of left ventricular hypertrophy, ventricular septal thickening, left atrial enlargement, aortic valve regurgitation and E/A<1 was higher in OSAHS+HT group than in OSAHS group (P<0.05, or P<0.01). The levels of serum CK, LDH and UA in OSAHS patients were positively correlated with AHI, but negatively correlated with SpO₂. There was no significant correlation between CK-MB and AHI, and SpO₂. Conclusion Severe OSAHS patients have increased serum myocardial enzymes and uric acid level. For OSAHS patients complicatedwith hypertension, uric acid and myocardial enzymes will increase more significantly. Patients with severe OSAHS may have abnormal cardiac structure and function, and hypertension may increase this probability. UA, CK and LDH are associated with the severity of OSAHS and degree of hypoxia.

Key words: Sleep apnea hypopnea syndrome, obstructive, Uric acid, Serum myocardial enzymes, Cardiac structure and function