JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (3): 103-106.doi: 10.6040/j.issn.1673-3770.0.2015.469

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Roles of multidrug resistance proteins P-gp and ABCG2 in laryngocatcinoma and their related signal pathways.

SU Tiantian, ZHANG Jia, SUN Zhenfeng   

  1. Department of Otolaryngology &Head and Neck Surgery, First Peoples Hospital of Shanghai Jiaotong University, Shanghai 200080, China
  • Received:2015-11-08 Online:2016-06-16 Published:2016-06-16

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Abstract: Laryngocatcinoma is a type of malignant solid tumor, and chemotherapy plays an increasingly important role in its treatment, but multidrug resistance(MDR)has become the leading cause of chemotherapy failure. Researches have showed that P-gp and ABCG2 proteins are important in the MDR of laryngocatcinoma, P-gp may be positively or negatively correlated with ABCG2, and their related signal pathways(MAPK)are related to their expressions in tumors. However, how P-gp and ABCG2 are controlled and how to improve the effect of chemotherapy remain to be further investigated.

Key words: ABCG2, Multidrug resistance, Laryngeal cancer, P-gp

CLC Number: 

  • R739.65
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