JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2017, Vol. 31 ›› Issue (1): 75-79.doi: 10.6040/j.issn.1673-3770.0.2016.190

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Clinical efficacy of Tiebifu Granule in the treatment of deafness with iron deficiency.


  1. Department of Otolaryngology &Head and Neck Surgery, Shanghai Changzheng Hospital, Shanghai 200003, China
  • Received:2016-04-29 Online:2017-02-16 Published:2017-02-16

Abstract: Objective To explore the clinical efficacy of Tiebifu Granule in the treatment of deafness with iron deficiency. Methods A total of 217 cases with iron deficiency including 163 cases of unilateral deaf and 54 cases of bilateral deaf were screened from 1 214 cases of sensorineural deafness and randomly divided into 2 groups: Tiebifu Granule group(n=109, taking Tiebifu Granule for 2 months)and control group(n=108, taking vitamin B1, mesylate, or methycobal for 2 months). The average threshold and serum ferritin were observed 1-3 days before medication, and 1 month and 2 months after taking medicine. Results One month after taking medicine, the serum ferritin level returned normal in 71.6% and 10.2% cases in the Tiebifu Granule group and control group, while the rate increased to 89% and 13.9% two months after taking medicine, showing significant difference between the two groups(P<0.001). The total effective rate of Tiebifu Granule group and control group was 52.3% and 22.2%, respectively, with significant difference between the two groups(P<0.001). Relevance between hearing improvement and serum ferritin increase was found in the Tiebifu Granule Group, but not in the control group. Conclusion Tiebifu Granule can effectively treat sensorineural deafness with iron deficiency.

Key words: Sensorineural deafness, Hearing threshold, Tiebifu Granule, Serum ferritin

CLC Number: 

  • R764
[1] 曹连杰, 余力生, 李兴启. 感音神经性聋高频听力易损机制[J]. 听力学及言语疾病杂志, 2010, 18(4):401-404.
[2] Murphy TP. Macrovascular sensorineural hearing loss[J]. Am J Otol, 1991, 12(2):88-92.
[3] Cole RR, JahrWistaroerfer RA. Sudden hearing loss: an update[J]. Am J Otol, 1998, 9(3):211-215.
[4] Le Prell CG, Yamashita D, Minami SB, et al. Mechanisms of noise-induced hearing loss indicate multiple methods of prevention[J]. Hear Res, 2007, 226(1-2):22-43.
[5] Prasher D. New strategies for prevention and treatment of noise-induced hearing loss[J]. Lancet, 1998, 352(9136):1240-1242.
[6] 孙爱华. 中西医结合治疗感觉神经性聋初步报告(附108例疗效分析)[J]. 中医杂志, 1981,(5):355-358.
[7] With adaptations from report of the first informal consultation on future organization development for the prevention of deafness and hearing impairment[J]. World Health Organization. Geneva, 1997, WHO/PDH/97.3.
[8] 叶应妩,王毓三, 申子瑜. 全国临床检验操作规程[S]. 3版. 南京: 东南大学出版社, 2006:392-393.
[9] Jougleux JL, Rioux FM, Church MW, et al. Mild maternal iron deficiency and lactation in guinea pigs causes abnormal auditory function in the offspring[J]. J Nutr, 2011, 141(7):1390-1395.
[10] Choudhury V, Amin SB, Agarwal A, et al. Latent iron deficiency at birth influences auditory neural maturation in late preterm and term infants[J]. American Journal of Clinical Nuturition, 2015, 102(5):1030-1034.
[11] Lin C, Lin SW, Lin YS, et al. Sudden sensorineural hearing loss is correlated with an increased risk of acute myocardial infarction: a population-based cohort study[J]. Laryngoscope, 2013, 123(9):2254-2258.
[12] 岳波, 孙爱华, 周怀恩, 等. 铁必复颗粒对缺铁诱发肾虚耳聋大鼠耳蜗蛋白质表达的影响[J]. 中国中西医结合耳鼻喉科杂志, 2011, 19(2):61-64. YUE Bo, SUN Aihua, ZHOU Huaien, et al. Effects of Tiebifu Granule on protein expression in the cochlea of rats with sensorineural hearing loss at the pattern of Kidney deficiency induced by iron insufficiency[J]. Chin J Otorhinolaryngol Integ Med, 2011, 19(2):61-64.
[13] Mosnier, Stepanisn A, Baron G, et al. Cardiovascular and thromboembolic risk factors in idiopathic sudden sensorineural hearing loss: a case-control study[J]. Audiol Neurootol, 2011, 16(1):55-66.
[14] Shiu-Dong Chung, Po-Yueh Chen, Herng-Ching Lin, et al. Sudden sensorineural hearing loss associated with lron-deficiency anemia: a population-based study[J]. JAMA Otolaryngol Head Neck Surg, 2014, 140(5):417-422.
[15] Jougleux JL, Rioux FM, Church MW, et al. Mild iron deficiency anemia during pregnancy and iactation in guinea pigs alters amplitudes and auditory nerve velocity, but not brainstem transmission times in the offsprings auditory brainstem response[J]. Nutr Neurosci, 2014, 17(1):37-47.
[16] Satish Saluja, Manoj Modi. Fetal-neonatal iron deficiency is associated with poorer auditory recognition memory at 2 months of age[J]. Evid Based Med, 2016, 21:112.
[17] Yu Fei, Hao Shuai, Yang Bo, et al. Mild maternal iron deficiency anemia induces hearing impairment associated with reduction of ribbon synapse density and dysregulation of VGLUT3, myosin vIIa, and prestin expression in young guinea pigs[J]. Neurotoxicity Research, 2016, 29(4):594-604.
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