Abstract: Objective To observe the clinical effect of autologous orbital periosteum combined with amniotic membrance transplantation in the reconstruction of external canthal eyelid defects. Methods Twelve eyes with defects of full-thickness external canthal eyelid due to eyelid tumor were included. All subjects underwent reconstruction of the full-thickness external canthal eyelid defects using autologous orbital periosteum combined with amniotic membrane and periorbital rotation glide flaps. All patients were followed for 6 to 60 months. Results All reconstructed eyelids showed natural appearance with good function and without deformities such as eyelid margin notch, irregular contractures of the upper margin, ectropion, or entropion. The implanted periosteum was not displaced, absorbed, or infected in any patient. All flaps were well healed, and there was no relapse of the eyelid tumor. Conclusion Autologous orbital periosteum is an ideal substitute for meibomian tissue. Amniotic membrane transplantation can effectively prevent or reduce the adhesion of eyelid and eyeball as well as vault stenosis. Autologous orbital periosteum combined with amniotic membrane to reconstruct severe external canthal eyelid defects has high clinical value, and is easily obtained, simple to use, with fewer complications and excellent curative effect.

Key words: Eyelid defect, Autologous orbital periosteum, Amniotic membrance, Eyelid reconstruction